Impact of Family History of Diabetes on<i>β</i>-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Chen, Gang; Li, Meizhi; Xu, Yuan; Chen, Nianhui; Huang, Huibin; Liang, Jing; Li, Liantao; Wen, Junping; Li, Lin; Yao, Jin

doi:10.1089/dia.2011.0245

Cited by 11 publications

(12 citation statements)

References 40 publications

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“…These results are in line with one study [24] which shows the influence of genetic factor on insulin biosynthesis and secretion. Another study [25] also shows that b-cell functional decline is associated with low HOMA-b value. The decrease in insulin secretion may be caused by several factors, and one of them is genetic factor [26].…”

Section: E23k Polymorphism In Kcnj11 Gene As Risk Factor Of Having a mentioning

confidence: 89%

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Sunita

Sadewa

Farmawati

2015

Egyptian Journal of Medical Human Genetics

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KEYWORDST2DM; E23K polymorphism of KCNJ11; HOMA-b; Individuals with family history of T2DM; Individuals without family history of T2DM Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and also environmental factors. Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, an ATP-sensitive potassium channel-coding gene, contributes to insulin secretion.Objectives: This research aimed to investigate E23K polymorphism in KCNJ11 gene and insulin secretion in individuals with family history of T2DM (cases) and without family history of T2DM (controls).Method: This research was a case-control study involving 34 cases and 34 controls. E23K polymorphism of KCNJ11 was detected with PCR-RFLP. All of the obtained data were statistically analyzed with T-test, Mann-Whitney U-test, Chi-Square and One-Way ANOVA.Result: Frequency of AA genotype in individuals with family history of T2DM (41%) was higher than in individuals without family history of T2DM (6%) (p = 0.001). Frequency of A allele in individuals with family history of T2DM (68%) was higher than in individuals without family history of T2DM (38%) (p = 0.001). The risk of A allele in individuals with family history of T2DM was 3 times higher than in individuals without family history of T2DM (p = 0.001, OR 3.38, CI 95% 1.67-6.84). Homeostasis Model Assessment b (HOMA-b) values of AA genotype (85.44% ± 39.55) were lower than that of GA (212.20% ± 79.30) and GG (254.00% ± 61.98) genotypes (p = 0.000).Conclusion: The risk of having A allele in individuals with family history of T2DM is higher than that in individuals without family history of T2DM. HOMA-b values of AA genotype are lower than that of GA and GG genotypes.

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Section: E23k Polymorphism In Kcnj11 Gene As Risk Factor Of Having a mentioning

confidence: 89%

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Sunita

Sadewa

Farmawati

2015

Egyptian Journal of Medical Human Genetics

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“…HOMA-β was employed for evaluation of pancreatic β-cell (Chen et al, 2012). HOMA-β values were parallel with the results of insulin levels, which is signifi cantly lower in subjects with a type 2 DM family history than in subjects without a type 2 DM family history.…”

Section: Discussionmentioning

confidence: 83%

“…The mean of insulin levels was lower among subjects with type 2 DM family history than subjects without type 2 DM family history (p=0.00). Chen et al (2012) and Arslanian et al (2005) also found that insulin level of subject with type 2 DM family history was lower than subjects without type 2 DM family history. The low insulin level on subjects with type 2 DM family history indicates that there was a decreasing insulin secretion due to abnormality of pancreatic β-cell (Arslanian et al, 2005).…”

Section: Discussionmentioning

confidence: 92%

“…HOMA-β values were parallel with the results of insulin levels, which is signifi cantly lower in subjects with a type 2 DM family history than in subjects without a type 2 DM family history. Chen et al (2012) was shown that individuals with type 2 DM family history has impaired function of pancreatic β-cell with low HOMA-β level compared with HOMA-β level of subjects without type 2 DM family history. The decreasing of insulin secretion resulted from impaired function of pancreatic β-cell which caused by several factor, include genetic factors (DeFronzo et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Insulin level was analyzed from blood serum by ELISA method (DRG ® kit) to obtain the HOMA-β level. The HOMA-β was calculated to determine the function of pancreatic beta cell with the following below (Chen et al, 2012;Oya et al, 2014):…”

Section: Blood Chemical Examinationmentioning

confidence: 99%

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Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History

2016

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Family history has considered as a risk factor of type 2 diabetes. Transcription factor-7 like 2 (TCF7L2) hasrole to regulates insulin secretion and blood glucose homeostasis. The aim of current study was to determine thers7903146 polymorphism of TCF7L2 gene and homeostatic model assessment-β (HOMA-β) level on individual withand without type 2 Diabetes Mellitus (DM) family history. This work is a case-control study. Thirty six subjectswith type 2 DM family history and 36 subjects without type 2 DM family history were recruited. HOMA-βmeasure to analyze the insulin secretion. Polymorphisms of TCF7L2 gene was analyzed by using PCR-RFLPmethod. Statistical analysis was performed by using T-test, Mann-Whitney and Chi-square with signifi cancelevel 0.05. The frequency of the T allele of the cases were 4.2% and the controls were 2.8% (p=0.500). The oddratio was 0.649 (CI;95%:0.106-4.055). The HOMA-β levels of the cases were signifi cant low (132.56±62.48)compared with the controls (266.09±1.68) with p=0.000. The subjects with type 2 DM family history have asimilar frequency of having T alleles and CT/TT genotypes. The subjects with type 2 DM family history hassignifi cantly lower HOMA-β levels than subject without DM family history.

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ABO, Tissue Typing, and Crossmatch Incompatibility

Zhang¹,

Rajalingam²,

Cecka³

et al. 2015

Transplantation of the Liver

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Impact of Family History of Diabetes onβ-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Cited by 11 publications

References 40 publications

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Polymorphism of Transcription Factor 7-Like 2 Gene and HOMA-β Level of Individuals With and Without Type 2 Diabetes Mellitus Family History

ABO, Tissue Typing, and Crossmatch Incompatibility

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