Impact of feeding regimens on the composition of gut microbiota and metabolite profiles of plasma and feces from Mongolian sheep

Wang, Bohui; Luo, Yulong; Su, Rongguo; Yao, Duo; Hou, Yanru; Liu, Chang; Du, Rui Fang; Jin, Yufeng

doi:10.1007/s12275-020-9501-0

Cited by 24 publications

(21 citation statements)

References 44 publications

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“…Other factors influencing gut microbiota structure includes geographical environment, which especially affects the richness of Prevotellaceae, Butyrivibrio, and Campylobacter [48]. Meanwhile, feeding regimens not only affect gut microbial composition, but also influence metabolic homeostasis in sheep [49,50]. Another study also demonstrated that feeding with rosemary leaves could alter the abundance of rumen microbial community into one that was dominant with bacterial species involved in protein degradation and methane production [51].…”

Section: Discussionmentioning

confidence: 99%

The gut bacterial diversity of sheep associated with different breeds in Qinghai province

et al. 2020

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Background: Gut microbiota play important roles in their co-evolution with mammals. However, little is understood about gut bacterial community of Tibetan sheep compared with other sheep breeds. In this study, we investigated the gut bacterial community in 4 different sheep breeds living in the Qinghai-Tibetan Plateau (QTP) of China using high-throughput sequencing (HTS) technique. Results: The results suggested that bacterial community abundance and breeds diversity of Tibetan sheep (TS) were significantly lower than that of the other three breeds of sheep [Dorset sheep (DrS), Dorper sheep (DrS) and Small Tail Han sheep (STHS)] (p < 0.05). Principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) analysis indicated that microbiome composition of TS was significantly different from that of other three sheep breeds (p < 0.01). Firmicutes was the most predominant microbial phylum in the gut, followed by Bacteroidetes. The gut bacterial community of TS showed higher proportions of phylum Spirochaetes, Proteobacteria and Verrucomicrobia, compared to the other three sheep breeds, but the Deferribacteres was absent in TS. At the genus level, Treponema, Succinivibrio, 5-7 N15 and Prevotella showed significantly higher abundance in TS than in the other three sheep breeds (p < 0.05). Conclusions: In this study, we first employed HTS to understand the gut microbiomes among different sheep breeds in QTP of China.

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Section: Discussionmentioning

confidence: 99%

The gut bacterial diversity of sheep associated with different breeds in Qinghai province

et al. 2020

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“…Moreover, histidine metabolism seems to be up-regulated under nutritional restriction. It was reported that plasma L-histidine level decreased in barn confinement sheep compared with free grazing sheep due to high body weight gain ( 32 ).…”

Section: Resultsmentioning

confidence: 99%

Metabolite Profile of Sheep Serum With High or Low Average Daily Gain

et al. 2021

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“…Bacterial abundance varied with GIT section, and substantial differences were observed among rumenabomasum, small intestine and large intestine. Most common were: Eubacterium, a genus that includes a wide spectrum of species [41]; Oscillibacter, an abundant genus in the faeces of free-grazing sheep (although with low values in the jejunum and ileum) that is linked to the production of butyric acid and alpha-linolenic acid [42]; and Ruminococcus, a genus of cellulose degraders found in various species. These three genera belong to the Firmicutes phyla and most of them can decompose bre and cellulose [22].…”

Section: Discussionmentioning

confidence: 99%

Bacterial communities in the gastrointestinal tract segments of helminth-resistant and helminth-susceptible sheep

Paz

Chua

Greeff

et al. 2021

Preprint

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Background Helminth parasitism is a world-wide problem in livestock industries, with major impacts on health, welfare and productivity. It has been the subject of decades of research, but little attention has been paid to the role of the gut microbiota in the responses to infection. The present study characterized the microbiome along the gastro-intestinal tract (GIT) of sheep and tested whether it had been affected by three decades of breeding for resistance to helminth infection. Australian Sheep Breeding Values (ASBVs) for faecal egg count (FEC) were used to select the 10 most worm-susceptible (High-FEC) and 10 most worm-resistant (Low-FEC) animals. DNA was extracted and sequenced for 16S rRNA gene from faeces and from the lumen of the rumen, abomasum, duodenum, jejunum, ileum, caecum, and colon. Results The most frequent genera identified along the GIT were Eubacterium, Oscillibacter, and Ruminococcus. Intersectoral-specialization zones were identified along the GIT, with the duodenum revealing major differences between the High-FEC (helminth-susceptible) and Low-FEC (helminth-resistant) animals in values for Alpha and Beta diversity. The High-FEC and Low-FEC sheep differed significantly for three phyla (Firmicutes, Elusimicrobia, Chloroflexi) and 11 genera. At other GIT sites, Firmicutes was the most abundant phylum followed by Bacteroidetes, and Proteobacteria presenting no major differences between High-FEC and Low-FEC. Conclusions The gastro-intestinal microbial profile varies widely between helminth-resistant and helminth-susceptible sheep. Each GIT section appears to supports a particular bacterial composition leading to inter-sectoral differences among the various microbial communities. The animal’s duodenum creates the right environment which results in a more diverse and richness microbial population in the helminth-resistant sheep and suggests that this population favours bacterial genera that generally ferment carbohydrates. The energy metabolism of sheep is largely based on the production of volatile fatty acids (acetate, butyrate, propionate) in the rumen, raising the possibility that butyrate-producing bacteria in the duodenum of helminth-resistant sheep, modulate the host’s metabolism and assist in the regulation of the parasite burden.

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Impact of feeding regimens on the composition of gut microbiota and metabolite profiles of plasma and feces from Mongolian sheep

Cited by 24 publications

References 44 publications

The gut bacterial diversity of sheep associated with different breeds in Qinghai province

The gut bacterial diversity of sheep associated with different breeds in Qinghai province

Metabolite Profile of Sheep Serum With High or Low Average Daily Gain

Bacterial communities in the gastrointestinal tract segments of helminth-resistant and helminth-susceptible sheep

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