Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Kafkoutsou, Alexia L; Yang, Yue; Zeynaloo, Elnaz; Deo, Sapna K.; Solle, Natasha Schaefer; Kobetz, Erin; Daunert, Sylvia; Caban‐Martinez, Alberto J.

doi:10.1097/jom.0000000000002527

Cited by 4 publications

(1 citation statement)

References 17 publications

(31 reference statements)

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“…HEK-293 cells were exposed to three widely used aqueous film forming foams (AFFFs). All AFFFs induced cytotoxicity and markedly inhibited cell proliferation when exposed to only one-tenth of the working concentration of fire suppression [ 115 ]. Therefore, the health effects of occupational exposure to PFAS on workers should not be ignored [ 116 ].…”

Section: Per- and Polyfluoroalkyl Substancesmentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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Section: Per- and Polyfluoroalkyl Substancesmentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Phytoremediation Potential of Azolla filiculoides: Uptake and Toxicity of Seven Per‐ and Polyfluoroalkyl Substances (PFAS) at Environmentally Relevant Water Concentrations

Lintern,

Scarlett,

Gagnon

et al. 2024

Enviro Toxic and Chemistry

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Environmental contamination of aquatic systems by per‐ and polyfluoroalkyl substances (PFAS) has generated significant health concerns. Remediation of contaminated sites such as the fire‐fighting emergency training grounds that use aqueous film‐forming foams is a high priority. Phytoremediation may help play a part in removing PFAS from such contaminated waters. We investigated the potential of the water fern Azolla filiculoides, which is used for phytoremediation of a wide range of contaminants, to uptake seven common PFAS (perfluorobutanoic acid [PFBA], perfluorobutane sulfonic acid [PFBS], perfluoroheptanoic acid [PFHpA], perfluorohexanoic acid [PFHxA], perfluorohexane sulfonic acid [PFHxS], perfluorooctanoic acid [PFOA], and perfluoropentanoic acid [PFPeA]), during a 12‐day exposure to environmentally relevant concentrations delivered as equimolar mixtures: low (∑PFAS = 0.0123 ± 1.89 μmol L−1), medium (∑PFAS = 0.123 ± 2.88 μmol L−1), and high (∑PFAS = 1.39 μmol L−1) treatments, equivalent to approximately 5, 50, and 500 µg L−1 total PFAS, respectively. The possible phytotoxic effects of PFAS were measured at 3‐day intervals using chlorophyll a content, photosystem II efficiency (Fv/Fm), performance index, and specific growth rate. The PFAS concentrations in plant tissue and water were also measured every 3 days using ultra‐high‐performance liquid chromatography—tandem mass spectrometry. Treatments with PFAS did not lead to any detectable phytotoxic effects. All seven PFAS were detected in plant tissue, with the greatest uptake occurring during the first 6 days of exposure. After 12 days of exposure, a maximum bioconcentration factor was recorded for PFBA of 1.30 and a minimum of 0.192 for PFBS. Consequently, the application of Azolla spp. as a stand‐alone system for phytoremediation of PFAS in aquatic environments is not sufficient to substantially reduce PFAS concentrations. Environ Toxicol Chem 2024;00:1–12. © 2024 The Author(s). Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Clinical, histological, molecular, and toxicokinetic renal outcomes of per-/polyfluoroalkyl substances (PFAS) exposure: Systematic review and meta-analysis

Hanvoravongchai,

Laochindawat,

Kimura

et al. 2024

Chemosphere

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Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality

Cited by 4 publications

References 17 publications

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Phytoremediation Potential of Azolla filiculoides: Uptake and Toxicity of Seven Per‐ and Polyfluoroalkyl Substances (PFAS) at Environmentally Relevant Water Concentrations

Clinical, histological, molecular, and toxicokinetic renal outcomes of per-/polyfluoroalkyl substances (PFAS) exposure: Systematic review and meta-analysis

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