Impact of fluorine on the phase behavior of bis-p-tolyl propane in supercritical CO2, 1,1-difluoroethane, and 1,1,1,2-tetrafluoroethane

Solubility of 4-Aminosalicylic Acid in Supercritical Carbon Dioxide and Subcritical 1,1,1,2-Tetrafluoroethane

“…Fortunately, polar solutes can easily dissolve in fluorohydrocarbon solvents, such as 1,1,1,2-tetrafluoroethane (R134a). 7 R134a is apyrous, nonexplosive, innocuous, non-ozonedepleting, nonirritating, noncorrosive, colorless, and tasteless, and it hardly contributes to global warming. 8 The critical pressure of R134a is 4.06 MPa, which is much lower than that of SCCO 2 (7.38 MPa).…”

“…This disadvantage results in the limitation of its applications in reaction, separation, and material preparation processes. Fortunately, polar solutes can easily dissolve in fluorohydrocarbon solvents, such as 1,1,1,2-tetrafluoroethane (R134a) . R134a is apyrous, nonexplosive, innocuous, non-ozone-depleting, nonirritating, noncorrosive, colorless, and tasteless, and it hardly contributes to global warming .…”

“…Generally, experimental techniques are either dynamic or static methods. In previous works, most of the measurements of the solubility of solids in SCCO 2 − and subcritical or supercritical R134a extraction , have employed dynamic and static methods, respectively. In the present work, reliable apparatuses were set up to accomplish the experiment.…”

Measurement and Correlation of the Solubilities of Azoxystrobin, Flutriafol, and Tebuconazole in Subcritical 1,1,1,2-Tetrafluoroethane

“…3,4 Fortunately, studies have found that fluorinated hydrocarbon solvents showed better solubilities for polar solutes than SCCO 2 due to their higher polarizability and permanent dipole moments. 5 As one of the most common fluorinated hydrocarbon solvents, 1,1,1,2-tetrafluoroethane (R134a) is apyrous, nonexplosive, innocuous, nonozonedepleting, nonirritating, noncorrosive, colorless, and tasteless, and it has a relatively slight contribution to global warming. 6,7 Meanwhile, the dipole moment of R134a is 2.1 D, and thus, it shows a better dissolving capacity for polar solutes; especially, its critical pressure of 4.06 MPa is easier to achieve, which makes R134a an excellent subcritical fluid solvent.…”

“…Among these supercritical fluids, supercritical carbon dioxide (SCCO 2 ) has been widely studied due to its accessible critical conditions ( T c = 304.15 K, P c = 7.38 MPa) and higher density than most supercritical fluids . However, SCCO 2 is a solvent with low polarizability, a low relative dielectric constant, and no dipole moment, which results in its low dissolving capacity for polar solutes, thus further limiting its extensive application, especially for some ionic compounds with high molecular weights. , Fortunately, studies have found that fluorinated hydrocarbon solvents showed better solubilities for polar solutes than SCCO 2 due to their higher polarizability and permanent dipole moments . As one of the most common fluorinated hydrocarbon solvents, 1,1,1,2-tetrafluoroethane (R134a) is apyrous, nonexplosive, innocuous, nonozone-depleting, nonirritating, noncorrosive, colorless, and tasteless, and it has a relatively slight contribution to global warming. , Meanwhile, the dipole moment of R134a is 2.1 D, and thus, it shows a better dissolving capacity for polar solutes; especially, its critical pressure of 4.06 MPa is easier to achieve, which makes R134a an excellent subcritical fluid solvent. , In principle, it may reduce experimental and operational costs in subcritical R134a extraction, purification, and enzymatic synthetic processes.…”