Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome

Piche, Thierry; Ducrotté, Philippe; Sabaté, Jean Marc; Coffin, Benoït; Zerbib, Frank; Dapoigny, Michel; Hua, Mau‐Sun; Mariné-Barjoan, Eugènia; Dainese, Raffaella; Hébuterne, Xavier

doi:10.1111/j.1365-2982.2010.01502.x

Cited by 83 publications

(83 citation statements)

References 32 publications

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“…Those reports have included the following findings: 35.4% (11/31), 45.6% (42/92), 59.7% (37/62), and 57% (23/40) of CD patients; 38% (7/18), 46% (23/50), 38.6% (17/44), and 33% (14/43) of UC patients. [10][11][12][13] In healthy adults, the prevalence of IBS using the Rome III diagnostic questionnaire was reported to be approximately 10% to 15%. [23][24][25] The Rome III classification is based on the symptom-based diagnostic criteria which is not explained by pathologically and endoscopically based disorders.…”

Section: Discussionmentioning

confidence: 99%

“…However, the reported studies had no control groups and were not consistent in the definition of inactive IBD or in the methods used for the diagnosis of IBS. [10][11][12][13] As a result, the true prevalence of IBS-like symptoms remained uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent reports suggest that IBD can manifest IBS-like symptoms such as diarrhea and abdominal pain, even after bowel inflammation has been eliminated and the patient has entered clinical remission or mucosal lesions have healed. [8][9][10][11][12][13][14][15][16] This has been attributed to the persistence of microinflammation in the mucosa and to increased permeability of the gastrointestinal mucosa. 17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

“…17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects. [8][9][10][11][12][13][14][15][16] These findings are of considerable interest as we attempt to deepen our understanding of the inactive IBD disease state.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, most of these studies used the Rome II definition; only a few Rome III reports are available. 10,12,13 In Japan, the prevalence of IBS complications in IBD has not been investigated on a large scale, so little is known about whether such complications are actually common among Japanese patients, and risk factors that may predispose patients to IBS-like symptoms have not been addressed.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita

Kato

Takimoto

et al. 2016

J Neurogastroenterol Motil

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Background/AimsFew studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD. MethodsIBS-like symptoms were evaluated using the Rome III questionnaire for functional gastrointestinal disorders. HR-QOL and hospital anxiety and depression scale were evaluated. Results IBS-like symptoms were found in 17.5% (7/40) of patients with inactive ulcerative colitis, 27.1% (29/107) of patients with inactive Crohn's disease (CD), and 5.3% (23/438) of healthy control subjects. The QOL level was significantly lower and anxiety score was significantly higher in inactive CD patients with IBS-like symptoms than in those without such symptoms (P = 0.003, P = 0.009). Use of anti-anxiety drugs was associated with the presence of IBS symptoms (P = 0.045). HR-QOL score was lower and anxiety score was higher in patients with inactive ulcerative colitis, but the difference was not statistically significant. ConclusionsThe prevalence of IBS-like symptoms in inactive IBD patients was significantly higher than in healthy controls. Inactive CD patients with IBS-like symptoms has low QOL and anxiety; suggesting that anxiety may be associated with symptom development in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita

Kato

Takimoto

et al. 2016

J Neurogastroenterol Motil

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The effects of gastrointestinal symptoms on structural grey matter volume in youth

Pirwani

Fang

et al. 2020

Intl J of Devlp Neuroscience

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Previous neuroimaging studies have examined the association between changes in brain structure and gastrointestinal symptoms (GIS), seen in disorders such as Irritable Bowel Syndrome and Irritable Bowel Disease. Studies in adults have found changes in white and grey matter volume (GMV) in patients with various gastrointestinal disorders. However, it is unclear whether GIS-related structural changes in the brain are limited to adults or could be present throughout the lifespan. Given that gastrointestinal disorders are typically diagnosed between 4 and 18 years old, we investigated GIS-induced morphological changes in pre-adolescents (8-10), adolescents (12-16 years) and young adults (17-21 years). Using a voxel-based morphometry (VBM) analysis, we compared regional grey matter volume (GMV) between participants with GIS and controls, using structural brain images from the Philadelphia Neurodevelopmental Cohort (PNC) database. A total of 211 participants (107 participants with GISs and 104 control participants) who had undergone structural magnetic resonance imaging were analysed. VBM analysis was used to objectively analyse GMV across the whole brain and compare between participants with GIS and controls. Participants experiencing GIS showed smaller GMV in regions within the limbic system/basal ganglia (bilateral caudate, bilateral ventral hippocampus, bilateral amygdala and bilateral superior orbital frontal cortex), and larger GMV in regions within the pain-matrix (thalamus, bilateral putamen, right mid-frontal gyrus) compared to controls. These differences were most prominent in the adolescent and young adult groups compared to pre-adolescents. In conclusion, the structural differences found in participants with GIS support the need for further research into the neurophysiological impact of these symptoms.

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Microbiota: a novel regulator of pain

et al. 2019

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Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome

Cited by 83 publications

References 32 publications

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

The effects of gastrointestinal symptoms on structural grey matter volume in youth

Microbiota: a novel regulator of pain

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