Impact of fungicides and weather on cyclodepsipeptide‐producing <i>Fusarium</i> spp. and beauvericin and enniatin levels in wheat grains

Decleer, Marlies; Landschoot, Sofie; Saeger, Sarah De; Rajković, Andreja; Audenaert, Kris

doi:10.1002/jsfa.9167

Cited by 19 publications

(17 citation statements)

References 35 publications

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“…There is a high occurrence of BEA in grains and wheat-based products like pasta, infant formulas, breakfast cereals, and biscuits, with incidences between 40 and 90% (Santini et al, 2012 ; Stanciu et al, 2017 ). In recent years, BEA has frequently been reported in different countries (South Africa, Norway, China, Croatia, Poland, Spain, Morocco…) as contaminants of, especially wheat, rye, oats, barley, and rice (Decleer et al, 2018 ). Seed-borne infection of wheat with F. proliferatum leads to contamination of wheat kernels with BEA (15–55 μg/kg) (Guo et al, 2016 ).…”

Section: Risk Assessment Of Beauvericin In Food and Feedmentioning

confidence: 99%

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Patočka

Nepovimová

et al. 2018

Front. Pharmacol.

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Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apoptosis. Recently, large evidence further shows that this mycotoxin has a variety of biological activities and is being considered a potential candidate for medicinal and pesticide research. It is noteworthy that BEA is a potential anticancer agent since it can increase the intracellular Ca2+ levels and induce the cancer cell death through oxidative stress and apoptosis. BEA has exhibited effective antibacterial activities against both pathogenic Gram-positive and Gram-negative bacteria. Importantly, BEA exhibits an effective capacity to inhibit the human immunodeficiency virus type-1 integrase. Moreover, BEA can simultaneously target drug resistance and morphogenesis which provides a promising strategy to combat life-threatening fungal infections. Thus, in this review, the synthesis and the biological activities of BEA, as well as, the underlying mechanisms, are fully analyzed. The risk assessment of BEA in food and feed are also discussed. We hope this review will help to further understand the biological activities of BEA and cast some new light on drug discovery.

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Section: Risk Assessment Of Beauvericin In Food and Feedmentioning

confidence: 99%

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Patočka

Nepovimová

et al. 2018

Front. Pharmacol.

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“…These variations of the species within the FHB complex may have been caused, among other factors, by the application of fungicides usually sprayed to control the disease, 55 possibly increasing the occurrence of less susceptible species in the heads 56 . Our in vitro experiments showed that tebuconazole, metconazole, prothioconazole and prochloraz were highly effective in controlling all four FHB causal agents.…”

Section: Discussionmentioning

confidence: 76%

Fungicides may have differential efficacies towards the main causal agents of Fusarium head blight of wheat

Tini

Beccari

Onofri

et al. 2020

Pest Management Science

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BACKGROUND: Fusarium head blight (FHB) is a complex disease of wheat and barley caused by several Fusarium species. In recent years, a variation in the composition of the FHB community has been observed in several wheat cultivation areas across the world. In detail, F. avenaceum and F. poae increased their frequencies, while, a lower F. graminearum and F. culmorum incidence was simultaneously observed. These shifts within the FHB complex might have been caused by different factors, including the selective pressure caused by fungicides used to control the disease in the field. Therefore, the present study was carried out to evaluate, both in in vitro experiments and in field trials, the activity of commonly used fungicides of wheat (tebuconazole, metconazole, prothioconazole and prochloraz) towards the above mentioned four Fusarium species. RESULTS: A preliminary in vitro assay revealed that low concentrations of all tested fungicides caused the incomplete reduction of fungal development. Furthermore, F. poae and F. avenaceum showed, at the same time, a lower sensitivity to all tested fungicides. In field trials, all fungicides showed an activity against the four Fusarium species. However, F. avenaceum exhibited a reduced sensitivity to metconazole. The lower efficacy of metconazole towards F. avenaceum was also confirmed by an additional in vitro experiment on several F. avenaceum and F. graminearum different strains. CONCLUSION: The selective pressure exerted by the extensive use of certain fungicides may influence population dynamics of Fusarium species due to their different sensitivity.

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“…Beauvericin was produced by all investigated fungi, with the most efficient producers being Fusarium strains, such as F. proliferatum (RT6.7, RT 5.4) and F. concentricum (P35). To some extent, all of the studied fungi are known producers of beauvericin [ 42 ], however, it is important to note that each fungal strain possesses unique abilities to produce different amounts of BEA, which can also be affected by the cultivation conditions [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the two phytopathogenic fungal species F. proliferatum and F. oxysporum did not synthesize enniatin analogues, although they have earlier been described as enniatin producers [ 16 , 29 , 42 , 60 ]. This suggests a need for comprehensive reevaluation of cyclodepsipeptide profiles across multiple representatives of known producing taxa, in particular as the production of enniatins may depend on cultivation conditions, storage conditions or the host and the environment from which the fungi were isolated [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Cyclodepsipeptide Biosynthesis in Hypocreales Fungi and Sequence Divergence of The Non-Ribosomal Peptide Synthase Genes

et al. 2020

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Fungi from the Hypocreales order synthesize a range of toxic non-ribosomal cyclic peptides with antimicrobial, insecticidal and cytotoxic activities. Entomopathogenic Beauveria, Isaria and Cordyceps as well as phytopathogenic Fusarium spp. are known producers of beauvericins (BEAs), beauvenniatins (BEAEs) or enniatins (ENNs). The compounds are synthesized by beauvericin/enniatin synthase (BEAS/ESYN1), which shows significant sequence divergence among Hypocreales members. We investigated ENN, BEA and BEAE production among entomopathogenic (Beauveria, Cordyceps, Isaria) and phytopathogenic (Fusarium) fungi; BEA and ENNs were quantified using an LC-MS/MS method. Phylogenetic analysis of partial sequences of putative BEAS/ESYN1 amplicons was also made. Nineteen fungal strains were identified based on sequence analysis of amplified ITS and tef-1α regions. BEA was produced by all investigated fungi, with F. proliferatum and F. concentricum being the most efficient producers. ENNs were synthesized mostly by F. acuminatum, F. avenaceum and C. confragosa. The phylogeny reconstruction suggests that ancestral BEA biosynthesis independently diverged into biosynthesis of other compounds. The divergent positioning of three Fusarium isolates raises the possibility of parallel acquisition of cyclic depsipeptide synthases in ancient complexes within Fusarium genus. Different fungi have independently evolved NRPS genes involved in depsipeptide biosynthesis, with functional adaptation towards biosynthesis of overlapping yet diversified metabolite profiles.

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Impact of fungicides and weather on cyclodepsipeptide‐producing Fusarium spp. and beauvericin and enniatin levels in wheat grains

Cited by 19 publications

References 35 publications

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Fungicides may have differential efficacies towards the main causal agents of Fusarium head blight of wheat

Cyclodepsipeptide Biosynthesis in Hypocreales Fungi and Sequence Divergence of The Non-Ribosomal Peptide Synthase Genes

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