Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance

Şahin, Ender; Katar, Mehmet Kağan; Can, İlknur

doi:10.1007/s00405-020-06089-2

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…Six studies which provided miscellaneous data about the association between reflux and sinonasal disorders that were not formally defined as CRS were excluded. [30][31][32][33][34][35]…”

Section: Resultsmentioning

confidence: 99%

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Lechien

Saussez

Hopkins

2023

Clinical Otolaryngology

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Objective: To investigate the association between laryngopharyngeal reflux (LPR), gastroesophageal reflux disease (GERD) and recalcitrant chronic rhinosinusitis (CRS).Data Sources: PubMed, Cochrane Library and Scopus.Review Methods: Three investigators searched the specified databases for studies investigating the relationship between LPR, GERD and recalcitrant CRS with or without polyposis. The following outcomes were investigated with PRISMA criteria: age; gender; reflux and CRS diagnosis; association outcomes and potential treatment outcomes. The authors performed a bias analysis of papers and provided recommendations for future studies.Results: A total of 17 studies investigated the association between reflux and recalcitrant CRS. According to pharyngeal pH monitoring, 54% of patients with recalcitrant CRS reported hypo or nasopharyngeal acid reflux events. The number of hypo-and nasopharyngeal acid reflux events was significantly higher in patients compared to healthy individuals in 4 and 2 studies, respectively. Only one study did not report intergroup differences. The proportion of GERD was significantly higher in CRS patients compared to controls, with a prevalence ranging from 32% to 91% of cases.No author considered nonacid reflux events. There was significant heterogeneity in the inclusion criteria; definition of reflux and association outcomes, limiting the ability to draw clear conclusions. Pepsin was found in sinonasal secretions more frequently in CRS patients than controls. Conclusion:Laryngopharyngeal reflux and GERD may be contributing factors of CRS therapeutic resistance, but future studies are needed to confirm the association considering nonacid reflux events.

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“…Six studies which provided miscellaneous data about the association between reflux and sinonasal disorders that were not formally defined as CRS were excluded. [30][31][32][33][34][35]…”

Section: Resultsmentioning

confidence: 99%

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Lechien

Saussez

Hopkins

2023

Clinical Otolaryngology

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“…It demonstrated that patients with gastric infection had increased nasal mucociliary clearance time compared to HP-negative patients, while the nasal mucociliary clearance time was normalized after eradication of gastric HP eradication, proposing that HP infection may have an essential role on the chronic sinusitis development. However, a major limitation of this study was the lack of examination for nasal HP colonization [ 30 ]. Consequently, further investigation is needed.…”

Section: Discussionmentioning

confidence: 99%

Detection of Helicobacter Pylori in Nasal Polyps: An Epidemiological Study

Zika

Fousekis

Exarchakos

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Many studies have described the detection of Helicobacter pylori (HP) in the nasal polyps; however, although gastroesophageal reflux has been associated with chronic rhinosinusitis and nasal polyps development, the role of HP remains unclear. Our aim was to describe the prevalence of HP detection in nasal polyps and its association with gastric HP infection and gastroesophageal reflux dsease (GERD). The prospective study involved 36 patients with nasal polyps, who underwent to endoscopic surgery removal of nasal polyps. Before surgical procedure all patients were tested for gastric HP infection by 13 C-urea breath test, while tissue samples from nasal polyps were tested for HP detection, using rapid urease test (CLO test) and histological examination with Giemsa stain. All patients were asked about GERD-related symptoms. HP in nasal polyps was detected in 9 out of 36 patients (25%) using histological examination with Giemsa stain, while the detection rate of HP was 30.5% (11/36) using CLO test. Furthermore, 28 out of 36 patients (77.7%) had gastric HP infection. All patients with HP colonization in nasal polyps had gastric HP infection and all patients with HP in nasal polyps reported symptoms related to GERD. HP was detected in approximately one out of three patients in nasal polyps, while all patients with HP detection in nasal polyps had concurrently gastric HP infection and reported GERD-related symptoms, suggesting a gastro-nasal route of HP.

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“…pylori-positive patients had a longer duration of NMC than H. pylori-negative patients [25]. Therefore, they speculated that eradication of H. pylori would have a positive effect on the prognosis of CRS.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between rhinosiusitis and gastroesophageal reflux disease： a bidirectional two-sample Mendelian randomization study

Chen,

Zhang,

Xie

et al. 2023

Preprint

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Background Gastroesophageal reflux disease (GERD) is associated with acute and chronic rhinosinusitis (ARS/CRS), although the causal relationship between them is not clear. Methods We conducted a bidirectional two-sample Mendelian randomized study to investigate the causal effects between GERD and rhinosinusitis (RS). The data for GERD and RS were obtained from large sample size genome-wide association studies (GWAS). Single-nucleotide polymorphisms (SNPs) associated with each exposure were considered instrumental variables in this study. We conducted a causal effect analysis using the inverse-variance weighted (IVW)，Weighted median，MR Egger，Simple mode and Weighted mode methods. The inverse-variance weighted and MR - Egger methods were used for the heterogeneity analysis. The MR - Egger model method was adopted for Pleiotropic effects. Results MR analysis showed that GERD had a statistically significant causal effect on ARS (IVW, OR = 1.324, 95% CI 1.177-1.490, p <0.001) and CRS (IVW, OR = 1.365, 95% CI 1.185-1.572, p <0.001).MR analysis showed that CRS had a statistically significant causal effect on GERD (IVW, OR = 1.033, 95% CI 1.009-1.056, p =0.006). However, the MR-Egger model revealed the evidence of horizontal pleiotropy for the causal effect of CRS on GERD (Egger-intercept=0.007, p=0.032). In addition，we did not observe a causal effect of ARS on GERD (IVW, OR = 1.019, 95% CI 0.986-1.053, p=0.269). Conclusions We confirmed the causal effect of GRED on RS, while no causal effect of RS on GERD was found. These studies are expected to provide high-quality causal evidence for the pathogenesis of RS and GERD, and additional ideas for their primary prevention and treatment.

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Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance

Cited by 8 publications

References 31 publications

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Detection of Helicobacter Pylori in Nasal Polyps: An Epidemiological Study

Causal relationships between rhinosiusitis and gastroesophageal reflux disease： a bidirectional two-sample Mendelian randomization study

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