Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance - an Australian perspective

Abstract

Parasitic nematodes (roundworms) of small ruminants and other livestock have major economic impacts worldwide. Despite the impact of the diseases caused by these nematodes and the discovery of new therapeutic agents (anthelmintics), there has been relatively limited progress in the development of practical molecular tools to study the epidemiology of these nematodes. Specific diagnosis underpins parasite control, and the detection and monitoring of anthelmintic resistance in livestock parasites, presently a major concern around the world. The purpose of the present article is to provide a concise account of the biology and knowledge of the epidemiology of the gastrointestinal nematodes (order Strongylida), from an Australian perspective, and to emphasize the importance of utilizing advanced molecular tools for the specific diagnosis of nematode infections for refined investigations of parasite epidemiology and drug resistance detection in combination with conventional methods. It also gives a perspective on the possibility of harnessing genetic, genomic and bioinformatic technologies to better understand parasites and control parasitic diseases.

Actividad depredadora in vitro de Lasioseius penicilliger (Arachnida: Mesostigmata) contra tres especies de nemátodos: Teladorsagia circumcincta, Meloidogyne sp. y Caenorhabditis elegans

“…Estas herramientas se aplican en las investigaciones de la epidemiología del parásito y de detección de resistencia a los medicamentos (Roeber et al, 2013). Por otra parte, la producción de diferentes cultivos se ve afectada por una variedad de organismos patógenos que perjudican gravemente la producción, desarrollo y vigor de las plantas (Back et al, 2002).…”

Proteomic identification of Galectin-11 and 14 ligands from Haemonchus contortus

“…Blood feeding by H. contortus results in haemorrhagic gastritis, oedema, diarrhoea and death in severe infections, leading to significant economic impact through decreased livestock production (Mavrot et al 2015;McLeod 1995;Roeber et al 2013). Sheep can develop effective immunity to H. contortus infection and vaccine-induced protection using H. contortus-derived molecules has been demonstrated, suggesting that the control of this parasite through vaccination is possible (Nisbet et al 2016).…”

Ovicidal activity of succinic acid isolated from sisal waste (Agave sisalana) against gastrointestinal nematodes of goats

“…These infections are responsible for a significant economic impact due to weight loss, reduced milk production and delayed growth (ROEBER et al, 2013). Development of nematode resistance to drugs commercially available encouraged the search for products of plant origin (FERREIRA et al, 2013).…”