Impact of Genetic Potential and Prematurity on Growth Outcomes

Idiopathic extremely short stature probably has several causes. Objective: To evaluate the influence of each parent’s height on clinical-biological features. Methods: 57 patients without intrauterine growth retardation seen at 7.9 ± 0.4 years for height ≤–3 SD were classified according to the difference between their target height and actual height: <2 SD in familial short stature (FSS, n = 28) and >2 SD in non-FSS (n = 29). Results: Height decreased from –0.5 ± 0.1 SD at birth to –2 ± 0.2 SD at 1 year and –2.7 ± 0.1 SD at 3 years, but the changes in the two groups were similar. FSS children were shorter than non-FSS children both at birth (p = 0.03) and as adults after growth hormone (GH) treatment (p < 0.05), but their plasma insulin-like growth factor I concentrations and GH peaks were similar. The FSS children fathers’ heights were more frequently below –2 SD (64%) than the mothers’ heights (35%) and were correlated with height at first evaluation (p < 0.05). For the whole population, the mothers’ heights were correlated with birth weight (p < 0.05) and with height at first evaluation (p < 0.03). Conclusion: This study confirms the influence of the mother’s height on birth weight and shows how of the father’s height influences idiopathic extremely short stature.

show abstract

Extreme Short Stature after Intrauterine Growth Retardation: Factors Associated with Lack of Catch-Up Growth

Edouard¹,

Trivin²,

Lawson-Body³

et al. 2004

Horm Res Paediatr

View full text Add to dashboard Cite

The factors associated with lack of catch-up growth after intrauterine growth retardation (IUGR) are unknown. Objective: To identify these factors by analyzing the clinical features and growth hormone (GH)-insulin-like growth factor I (IGF-I) axis. Methods: 95 patients with height <–3 SD after IUGR were assigned to group 1 without (n = 50) or group 2 with (n = 45) malformations. Twenty-one in group 1 and 19 in group 2 were treated with GH. Results: They were seen at 5.3 ± 0.5 and 4 ± 0.5 year (p = 0.02) with heights at –3.4 ± 0.1 and –3.9 ± 0.2 SD (p = 0.03). Group 1 differed from group 2 in having a lower frequency of consanguinity (2 vs. 28.9%, p < 0.001), and higher frequencies of target heights (26.5 vs. 6.7%, p = 0.02) and mothers’ heights (34.7 vs. 8.9%, p < 0.01) <–2 SD, multiparity (26 vs. 8.9%, p < 0.05), prematurity (36 vs. 15.5%, p < 0.05) and cesarean section birth (42 vs. 17.8%, p = 0.01). The GH-IGF-I axis data and the height increases after 3 years of GH treatment (1.6 ± 0.2 in group 1 and 1.1 ± 0.3 SD in group 2) were similar. Conclusion: The short height of the parents, particularly of the mother, is associated with factors limiting the catch-up growth after IUGR of children without malformations, while the high frequency of consanguinity in those with malformations suggests that transmitted fetal factors affect organogenesis or development.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Impact of Genetic Potential and Prematurity on Growth Outcomes

Abstract: Parents and providers can be reassured that many children overcome the adverse effects of prematurity on childhood growth. Throughout childhood, growth should be closely monitored using appropriate grids, and correcting for prematurity.

Cited by 3 publications

References 17 publications

Obtaining Accurate Growth Measurements in Children

Obtaining Accurate Growth Measurements in Children

Extremely Short Stature: Influence of Each Parent’s Height on Clinical-Biological Features

Extreme Short Stature after Intrauterine Growth Retardation: Factors Associated with Lack of Catch-Up Growth

Contact Info

Product

Resources

About