Impact of genetic variations in C-C chemokine receptors and ligands on infectious diseases

Qidwai, Tabish; Khan, M. Firoze

doi:10.1016/j.humimm.2016.06.010

Cited by 23 publications

(17 citation statements)

References 144 publications

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“…Their biological activity is mediated by specific G protein-coupled receptors expressed on the surface of several cell types ( 9 – 11 ). CC-chemokine ligands and receptors are involved in the pathogenesis of cardiac and infectious diseases ( 12 , 13 ). In chronic CD, CCL5/RANTES and CCL2/MCP-1 serum concentrations and the frequencies of peripheral blood CCR5 + T cells and macrophages are increased in cardiopathic patients ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

“…The expression of chemokine ligands and receptors is partially controlled by genetic polymorphisms, potentially contributing to differential patterns of cell migration and effector activities in health and disease ( 13 , 20 ). Previous studies have investigated the potential contribution of single nucleotide polymorphisms (SNPs) in genes encoding CC-chemokine ligands and receptors to CD outcome.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

Batista

Alvarado-Arnez

Alves³

et al. 2018

Front. Immunol.

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Chronic cardiomyopathy is the main clinical manifestation of Chagas disease (CD), a disease caused by Trypanosoma cruzi infection. A hallmark of chronic chagasic cardiomyopathy (CCC) is a fibrogenic inflammation mainly composed of CD8+ and CD4+ T cells and macrophages. CC-chemokine ligands and receptors have been proposed to drive cell migration toward the heart tissue of CD patients. Single nucleotide polymorphisms (SNPs) in CC-chemokine ligand and receptor genes may determine protein expression. Herein, we evaluated the association of SNPs in the CC-chemokines CCL2 (rs1024611) and CCL5 (rs2107538, rs2280788) and the CCL5/RANTES receptors CCR1 (rs3181077, rs1491961, rs3136672) and CCR5 (rs1799987) with risk and progression toward CCC. We performed a cross-sectional association study of 406 seropositive patients from endemic areas for CD in the State of Pernambuco, Northeast Brazil. The patients were classified as non-cardiopathic (A, n = 110) or cardiopathic (mild, B1, n = 163; severe, C, n = 133). Serum levels of CCL5 and CCL2/MCP-1 were elevated in CD patients but were neither associated with risk/severity of CCC nor with SNP genotypes. After logistic regression analysis with adjustment for the covariates gender and ethnicity, CCL5 −403 (rs2107538) CT heterozygotes (OR = 0.5, P-value = 0.04) and T carriers (OR = 0.5, P-value = 0.01) were associated with protection against CCC. To gain insight into the participation of the CCL5–CCR5/CCR1 axis in CCC, mice were infected with the Colombian T. cruzi strain. Increased CCL5 concentrations were detected in cardiac tissue. In spleen, frequencies of CCR1+ CD8+ T cells and CD14+ macrophages were decreased, while frequencies of CCR5+ cells were increased. Importantly, CCR1+CD14+ macrophages were mainly IL-10+, while CCR5+ cells were mostly TNF+. CCR5-deficient infected mice presented reduced TNF concentrations and injury in heart tissue. Selective blockade of CCR1 (Met-RANTES therapy) in infected Ccr5−/− mice supported a protective role for CCR1 in CCC. Furthermore, parasite antigen stimulation of CD patient blood cells increased the frequency of CCR1+CD8+ T cells and CCL5 production. Collectively, our data support that a genetic variant of CCL5 and CCR1+ cells confer protection against Chagas heart disease, identifying the CCL5-CCR1 axis as a target for immunostimulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

Batista

Alvarado-Arnez

Alves³

et al. 2018

Front. Immunol.

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“…Chemokines are classified into four subfamilies: C, CC, CXC, and CX3C ( 80 ). HIV T-tropic or X4 strains preferentially infect T cells, whereas M-tropic or R5 strains infecting both macrophages and T cells.…”

Section: Resultsmentioning

confidence: 99%

Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection

Liu

Gorny

2018

Front. Immunol.

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Disease progression among HIV-1–infected individuals varies widely, but the mechanisms underlying this variability remains unknown. Distinct disease outcomes are the consequences of many factors working in concert, including innate and adaptive immune responses, cell-mediated and humoral immunity, and both genetic and phenotypic factors. Current data suggest that these multifaceted aspects in infected individuals should be considered as a whole, rather than as separate unique elements, and that analyses must be performed in greater detail in order to meet the requirements of personalized medicine and guide optimal vaccine design. However, the wide adoption of antiretroviral therapy (ART) influences the implementation of systematic analyses of the HIV-1–infected population. Consequently, fewer data will be available for acquisition in the future, preventing the comprehensive investigations required to elucidate the underpinnings of variability in disease outcome. This review seeks to recapitulate the distinct genotypic and phenotypic features of the immune system, focusing in particular on comparing the surface proteins of immune cells among individuals with different HIV infection outcomes.

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“…In mammals, 10 members of CCRs subfamily, including CCR1-10, have been identified with standard chemotactic functions (Griffith et al 2014). There is increasing evidence that CCRs were associated with the pathogenesis of many diseases, and mutations in some CCRs could be beneficial for lowering disease impact and increasing the ability to antagonize some pathogens (Qidwai and Khan 2016). CCL25 was identified as a novel chemokine in the late 1990s, and is chemotactic for lymphocytes, dendritic cells (DCs), and activated macrophages (Vicari et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization and expression analysis of the CCR9 gene from cobia (Rachycentron canadum) following bacterial and poly I:C challenge

Deng

Cheng

et al. 2019

Journal of Applied Animal Research

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Chemokine receptors play an important role in coordination of cell trafficking in many biological processes. In this study, a CC chemokine receptor 9 of cobia Rachycentron canadum (RcCCR9) was identified. Analysis of the ORF (1119 bp) of RcCCR9 revealed a predicted protein of 41.87 kDa with typical seven transmembrane domain architecture. RcCCR9 shared several conserved structural features with homologs from mammals and other fish, and had a consistent relationship with phylogenetic trees and sequence identities. Reverse transcription quantitative PCR analysis showed ubiquitous RcCCR9 transcripts in healthy cobia, mainly in immune-related organs, with the highest levels in blood and lower levels in intestines and brain. After challenge with inactivated Vibrio harveyi or viral mimic poly I:C, RcCCR9 expression was up-regulated in head kidney and down-regulated in spleen. Compared with poly I:C, V. harveyi induced a stronger up/down-regulation of CCR9 mRNA levels in the central immune organs. RcCCR9 seems to be strongly involved in host defense against bacterial infection. ARTICLE HISTORY

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Impact of genetic variations in C-C chemokine receptors and ligands on infectious diseases

Cited by 23 publications

References 144 publications

Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection

Molecular characterization and expression analysis of the CCR9 gene from cobia (Rachycentron canadum) following bacterial and poly I:C challenge

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