Impact of Gum acacia on oxidative stress and apoptosis in Adenine-induced CKD animal model

Abstract

Objective: This study was conducted in order to investigate the protective effect of Gum acacia (GA) on adenine-induced chronic kidney disease (CKD) on anti-inflammatory and apoptotic markers. Materials and methods: Sprague-Dawley rats (n = 30) were divided into three groups at random and given the following treatments for four weeks straight: group 1: Control: continued on the same diet without treatment until the study's conclusion; group 2: Adenine: changed to a powder diet containing adenine (0.75 % w/w in feed); group 3: Adenine + GA: adenine was supplied in the feed as in the second group for 4 weeks, then gum acacia was added to the drinking water at a concentration of 15 %t w/v. Adenine feeding was used to cause CKD in rats, and gum acacia, GA, was used to cure it concurrently (15 % in drinking water). Results: Adenine increased kidney function, lipid peroxidation, P53, caspase-3, Bax, and transforming growth factor (TGF-ß) compared to normal controls. While some antioxidants and B-cell lymphoma 2 (Bcl-2) were on the decline.Concurrent GA therapy considerably lowered these negative effects. When combined, GA lowers oxidative stress and inflammation in CKD-affected rats. Conclusions: We come to the conclusion that the induction of CKD in rats by the administration of adenine is accompanied with oxidative stress, apoptosis, and inflammation. The benefits of GA in adenine-induced CKD are linked to the reduction of adenine-induced oxidative stress, apoptosis, and inflammation.