Impact of heavy metals on the female reproductive system

Rzymski, Piotr; Tomczyk, Katarzyna; Rzymski, Paweł; Poniedziałek, Barbara; Opala, Tomasz; Wilczak, Maciej

doi:10.5604/12321966.1152077

Cited by 205 publications

(137 citation statements)

References 36 publications

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“…Potentially their concentration may be amplified by bioaccumulation within the food chain, particularly individuals with high fish intake which may be at risk of exposure to mercury. Some of these metals are essential for life in low concentrations, but highly toxic in higher concentrations, such as copper, chromium, manganese, and zinc, although cadmium, lead, mercury, and the metalloid arsenic are nonessential and are toxic (290). Women are exposed to these chemicals through inhalation, drinking contaminated water, or eating food contaminated by exposure or by bioaccumulation.…”

Section: V) Phytoestrogensmentioning

confidence: 99%

“…Evidence exists for some heavy metals to have a potential epigenetic modification influence on various cultured cell lines (290), influencing DNA methylation leading to gene inactivation loss of acetylation and increasing histone methylation (12) as well as activating apoptosis, and arsenic is known to disrupt the cell cycle (12,104). In women undergoing IVF treatment, higher mercury exposure has been associated with altered methylation patterns within CpG sites within whole blood, and cadmium exposure has been linked to altered methylation patterns in Andean women from Argentina, suggesting that these laboratory-observed influences on epigenetic modifications may occur at concentrations present within the environment.…”

Section: V) Phytoestrogensmentioning

confidence: 99%

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Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

175

119

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Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessive exercise, the increasing prevalence of sexually transmitted diseases, and smoking all have significant negative effects on fertility. Other factors that impede conception are the perceived increasing prevalence of the polycystic ovary syndrome, which is further exacerbated by obesity, and the presence of uterine fibroids and endometriosis (a progressive pelvic inflammatory disorder) which are more prevalent in older women. A tendency for an earlier sexual debut and to have more sexual partners has led to an increase in sexually transmitted diseases. In addition, there are several genetic influences that may limit the number of oocytes within the ovary; consequently, by postponing attempts at childbearing, a limitation of oocyte number may become evident, whereas in previous generations with earlier conception this potentially reduced reproductive life span did not manifest in infertility. Environmental influences on reproduction are under increasing scrutiny. Although firm evidence is lacking however, dioxin exposure may be linked to endometriosis, phthalate exposure may influence ovarian reserve, and bisphenol A may interfere with oocyte development and maturation. However, chemotherapy or radiotherapy is recognized to lead to ovarian damage and predispose the woman to ovarian failure.

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Section: V) Phytoestrogensmentioning

confidence: 99%

Section: V) Phytoestrogensmentioning

confidence: 99%

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

175

119

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“…The origin of this phenomenon, however, is no longer a mystery with no leads. One of the factors that may be responsible for this phenomenon is contamination of the environment with heavy metals [3,4]. The pollution of air, water and soil with heavy metals and their compounds leads to their presence in foods.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Wdowiak¹,

Wdowiak²,

Bojar³

2018

Ann Agric Environ Med.

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This study investigated the influence of cadmium (Cd), copper (Cu), iron (Fe), lead (Pb), selenium (Se), and zinc (Zn) in follicular fluid on the effectiveness of in vitro fertilization (IVF) treatment and the dynamics of embryo development. The study involved 221 women aged 25-35 years in whom intracytoplasmic sperm injection (ICSI) was performed. Analysis of the effects of the average concentrations of Se, Zn, and Cu on the developmental dynamics of embryos showed that higher concentrations of these metals were accompanied by shorter lead times for each of the various stages of development, while the reverse was true in the case of cadmium and lead. No relationship was observed between the mean concentrations of Fe and the dynamics of the human embryo. In order to discover whether the fact of becoming pregnant is affected by the investigated variables, a logistic regression model was applied. The dependent variable was the fact of achieving pregnancy, and the independent variable tested was the level of trace metals. Ultimately, only one variable remained statistically significant in the model: the level of Se.

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“…The increased REEs concentrations in human have been so far associated with mining and smelting areas (Wei et al 2013;Hao et al 2015;Wang et al 2017). However, urban populations have been shown to reveal elevated levels of certain pollutants such as arsenic, mercury, platinum group elements, cadmium, and lead in blood, tissue, urinary, and hair (Iavicoli et al 2007;Rzymski et al 2015;Roca et al 2016;Rzymski et al 2016b). The present study did not detect any statistically significant differences in the content of REEs in colostrum milk in relation to inhabited area.…”

Section: Discussionmentioning

confidence: 99%

Rare-earth elements in human colostrum milk

Poniedziałek

Rzymski

Pięt

et al. 2017

Environ Sci Pollut Res

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Rare-earth elements (REEs) are used in a growing number of applications, and their release to environment has increased over the decades. Knowledge of REEs in human milk and factors that could possibly influence their concentration is scarce. This study evaluated the concentrations of 16 REEs (Ce, Eu, Er, Gd, La, Nd, Pr, Sc, Sm, Dy, Ho, Lu, Tb, Tm, Y, and Yb) in human colostrum milk collected from Polish women (n = 100) with the ICP-OES technique. The concentrations (mean ± SD) of Pr (41.9 ± 13.2 μg L −1 ), Nd (11.0 ± 4.0 μg L −1 ), La (7.1 ± 5.2 μg L −1 ), and Er (2.2 ± 0.8 μg L −1 ) were found above detection limits. The total mean ± SD concentration of detected REEs was 60.9 ± 17.8 μg L −1 . Current smokers displayed significantly increased Nd concentrations compared to women who had never smoked. No other associations between REEs in colostrum milk and age, diet in pregnancy (food supplement use and frequency of fish, meat, and vegetable consumption) or place of living (urban/rural) were found. This study adds to general understanding of the occurrence and turnover of REEs in women and human fluids.

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Impact of heavy metals on the female reproductive system

Cited by 205 publications

References 36 publications

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Rare-earth elements in human colostrum milk

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