Impact of Hepatitis C Virus Coinfection on Response to Highly Active Antiretroviral Therapy and Outcome in HIV-Infected Individuals: A Nationwide Cohort Study

Weis, Nina; Lindhardt, Bjarne Ørskov; Kronborg, Gitte; Hansen, Ann‐Brit Eg; Laursen, Alex Lund; Christensen, Peer Brehm; Nielsen, Henrik; Møller, Axel; Sørensen, Henrik Toft; Obel, Niels

doi:10.1086/503569

Cited by 87 publications

(86 citation statements)

References 22 publications

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“…C54 did not display a decrease in the CD4 ϩ cell count, suggesting reduced pathogenicity of the infecting strain. However, findings for this individual are complicated by coinfection with hepatitis C, which has been implicated in increased mortality for HIV-1-infected individuals (54). All viruses isolated from the SBBC members studied were found to use CCR5 as the primary coreceptor, with the exception of isolates from the donor, D36, which were able to utilize both CCR5 and CXCR4.…”

Section: Discussionmentioning

confidence: 95%

Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in thenefand Long Terminal Repeat Regions

Verity

Zotos

Wilson

et al. 2007

J Virol

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The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nefattenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show that viral phenotypes and antibody responses differ considerably between individual cohort members, despite the single source of infection. Replication of isolated virus varied from barely detectable to similar to that of the wild-type virus, and virus isolated from five SBBC members showed coreceptor usage signatures unique to each individual. Higher viral loads and stronger neutralizing antibody responses were associated with betterreplicating viral strains, and detectable viral replication was essential for the development of strong and sustained humoral immune responses. Despite the presence of strong neutralizing antibodies in a number of SBBC members, disease progression was not prevented, and each cohort member studied displayed a unique outcome of infection with nef-attenuated HIV-1.

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Section: Discussionmentioning

confidence: 95%

Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in thenefand Long Terminal Repeat Regions

Verity

Zotos

Wilson

et al. 2007

J Virol

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show abstract

“…Coinfected patients on antiretroviral therapy have been shown to have higher rates of mortality than HCV patients not infected with HIV [7,8]. The goal of PEG-IFN/RBV treatment is to achieve a sustained virologic response (SVR), defined as an undetectable HCV-RNA titer 6 months after completing treatment.…”

Section: Hiv Coinfection Hastens Progression Of Hcv/liver Diseasementioning

confidence: 99%

Psychiatric behavioral aspects of comanagement of hepatitis C virus and HIV

Weiss

Gorman²

2006

Curr HIV/AIDS Rep

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Coinfection with HIV hastens the progression of liver disease in persons with hepatitis C virus (HCV) infection. As mortality directly due to HIV continues to decrease among persons who are HIVpositive, coinfection with HCV has emerged as a leading cause of death. There is increasing attention to the need to actively treat HCV infection in HIV/HCV coinfected patients. Current HCV treatment with pegylated interferon and ribavirin achieves sustained viral response in up to 40% of coinfected patients but has numerous neuropsychiatric side effects. Providers are hesitant to begin HCV treatment in the coinfected population given the high prevalence of existing psychiatric illness, cognitive impairment, and substance use disorders. There is an urgent need for research into the psychiatric and behavioral predictors of HCV treatment adherence and virologic outcome, as well as into the optimal psychiatric management of the neuropsychiatric sequelae of HCV therapy.

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“…HBV and HCV are of concerns because both viruses compromise liver function, which may further affect the metabolism and therapeutic effect of antiretroviral drugs (ARV) for AIDS patients (11)(12)(13). They are also classified as group one causative agents of hepatocellular carcinoma (HCC) by International Agency for Research on Cancer (IARC).…”

Section: Introductionmentioning

confidence: 99%

Multiple viral coinfections among HIV/AIDS patients in China

Chen

Lin

et al. 2011

BST

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Impact of Hepatitis C Virus Coinfection on Response to Highly Active Antiretroviral Therapy and Outcome in HIV-Infected Individuals: A Nationwide Cohort Study

Abstract: HIV-HCV-coinfected patients are compromised in their response to highly active antiretroviral therapy. Overall mortality, as well as mortality from liver-related and acquired immunodeficiency syndrome-related causes, is significantly increased in this patient group.

Cited by 87 publications

References 22 publications

Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in thenefand Long Terminal Repeat Regions

Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in thenefand Long Terminal Repeat Regions

Psychiatric behavioral aspects of comanagement of hepatitis C virus and HIV

Multiple viral coinfections among HIV/AIDS patients in China

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