Impact of high-sensitivity C-reactive protein on coronary artery disease severity and outcomes in patients undergoing percutaneous coronary intervention

Liu, Yue; Jia, Sida; Yao, Yi; Tang, Xiaofang; Xu, Na; Jiang, Lin; Gao, Zhan; Chen, Jue; Yang, Yuejin; Gao, Runlin; Xu, Bo; Yuan, Jinqing

doi:10.1016/j.jjcc.2019.06.012

Cited by 32 publications

(25 citation statements)

References 44 publications

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“…Four studies investigated the relationship between PLR and CSF 23 –26 ; 423 SCF patients and 485 controls were included in meta-analysis. Since the I 2 for the studies was 95%, random effects model was chosen to evaluate MD in 2 groups. Overall, SCF patients had a higher PLR than those with normal coronary flow (MD: 49.01, 95% CI: 11.10-86.92, P = .01; Figure 5).…”

Section: Resultsmentioning

confidence: 99%

“…1 Therefore, it is not surprising that inflammatory biomarkers such as neutrophil and platelet counts, red blood cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio (PLR) are elevated in patients with coronary artery disease (CAD). [2][3][4][5] Platelets play an important role in the development of atherosclerosis. 6 They release immunomodulatory mediators, such as prostaglandin E2, platelet-activating factor, which contribute to inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies

Qiu

Jiang

et al. 2020

Angiology

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Recent studies have reported a relationship between the platelet to lymphocyte ratio (PLR) and acute coronary syndromes. The aim of the present study was to investigate the association between PLR and stable coronary artery disease (CAD). A systematic search was conducted based on electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase). A total of 14 studies (n = 4,871) were included in the meta-analysis. Compared with the non-CAD group, PLR was significantly higher in CAD group ( P = .002). After further classification according to the Gensini score, the cases with atherosclerosis demonstrated a higher PLR than those without atherosclerosis ( P < .001). Platelet to lymphocyte ratio was higher in the severe atherosclerosis group compared with the mild atherosclerosis group ( P < .001). Compared with the poor coronary collateral circulation (CCC) group, PLR was significantly lower in the good CCC group ( P < .001). The PLR was significantly higher in patients with coronary slow flow (CSF) than those with normal coronary flow ( P = .01). On the basis of current evidence, an elevated PLR was associated with stable CAD, and it might be useful for predicting CAD severe stenosis, collateral circulation, and CSF. Future studies are needed to clarify the relationship between PLR and stable CAD.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies

Qiu

Jiang

et al. 2020

Angiology

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“… 30 Higher CRP levels increase the risk of hypertension and cerebrovascular disease. 31 In this study, we found that VEGF and eNOS expression in plasma and placental tissues from pregnancy-induced hypertension rats were lower, but CRP levels were higher compared with the control group. Therefore, our results indicated that pregnancy-induced hypertension is associated with vascular endothelial injury.…”

Section: Discussionmentioning

confidence: 52%

Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage

et al. 2020

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Objective Baicalin is a compound extracted from the dried root of Scutellaria baicalensis Georgi. Studies have shown that baicalin has a protective effect on vascular endothelial cells, but whether baicalin could alleviate ascular endothelial cell damage in pregnancy-induced hypertensive patients remains unknown. Materials and methods We established a hypertensive pregnant rat model to study vascular endothelial injury during pregnancy-induced hypertension. Plasma epoprostenol (PGI-2), thromboxane A2 (Txa-2), β-human chorionic gonadotropin (β-HCG), and estrogen levels in rats were detected using ELISA. Vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and C-reactive protein (CRP) expression were detected using western blotting and quantitative PCR (q-PCR). Results Results showed that baicalin alleviated symptoms of pregnancy-induced hypertension. CRP, Txa-2, and β-HCG expression were significantly upregulated, while VEGF, eNOS, PGI-2, and estrogen expression was decreased in plasma and placental tissues of hypertensive rats. However, the levels of these injury indicators were significantly decreased after baicalin therapy, while the expression of protective indicators was significantly increased. Conclusion Baicalin reversed vascular endothelial cell injury in pregnant hypertensive rats by promoting VEGF, eNOS, PGI-2, and estrogen expression.

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“…The hsCRP level has been reported to be associated with Syntax score. [25][26][27] MHR was initially discovered to be associated with cardiovascular outcomes and was identified as an independent predictor of major adverse cardiovascular events in patients with chronic kidney disease. 28 The positive correlation of MHR with Syntax score in patients with stable CAD has been identified in several studies.…”

Section: Discussionmentioning

confidence: 99%

<p>The Association of Syntax Score with Levels of Lipoprotein(a) and Inflammatory Biomarkers in Patients with Stable Coronary Artery Disease and Different Low-Density Lipoprotein Cholesterol Levels</p>

Xu¹,

Guan²,

Gao³

et al. 2020

DMSO

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Introduction Lipoprotein(a) (Lp(a)) is associated with the severity of coronary lesions evaluated using Syntax score in patients with stable coronary artery disease (CAD). However, the effect of low-density lipoprotein cholesterol (LDL-C) levels on the association of Lp(a) levels with Syntax score remains unclear. Methods A total of 646 patients with stable CAD were enrolled in the present study. Lp(a) levels were measured with an AU5800 Chemistry Analyzer. Syntax scores were calculated by two advanced interventional cardiologists. SPSS 22.0 was used for statistical analyses. Results The concentration of Lp(a) ranged from 1 to 192 mg/dL. Pearson’s correlation analysis showed a positive correlation between Syntax score and the level of Lp(a) (r = 0.108, p = 0.006). The LDL-C ≥100 mg/dL group presented with a higher Lp(a) level, 16 (9–29) vs 13 (7–24). Pearson’s correlation analysis identified a correlation between Lp(a) level and Syntax score (r = 0.249, p < 0.001) only in the LDL-C ≥100 mg/dL group. Multivariate logistic regression analysis revealed the positive predictive value of an Lp(a) level >30 mg/dL for a Syntax score ≥23 only in the LDL-C ≥100 mg/dL group, adjusted odds ratio 2.895, p = 0.010. A receiver operating characteristic curve analysis confirmed the predictive value of Lp(a) levels for a Syntax score ≥23 in the LDL-C ≥100 mg/dL group with a cutoff value for Lp(a) >30 mg/dL. Discussion The association between Lp(a) level and Syntax score was only maintained in the LDL-C ≥100 mg/dL group. An Lp(a) level >30 mg/dL was an independent predictor of a Syntax score ≥23 only in the LDL-C ≥100 mg/dL group. The effect of LDL-C levels on the association of Lp(a) levels with Syntax score requires further investigations.

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Impact of high-sensitivity C-reactive protein on coronary artery disease severity and outcomes in patients undergoing percutaneous coronary intervention

Cited by 32 publications

References 44 publications

Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies

Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies

Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage

<p>The Association of Syntax Score with Levels of Lipoprotein(a) and Inflammatory Biomarkers in Patients with Stable Coronary Artery Disease and Different Low-Density Lipoprotein Cholesterol Levels</p>

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