Impact of highly active antiretroviral therapy on the morbidity and mortality in Spanish human immunodeficiency virus-infected children

Granados, José Manuel; Amador, José Tomás Ramos; Miguel, Sira FernÁndez De; Tomé, María Isabel González; Conejo, Pablo Rojo; Vivas, Paloma Ferrando; PollÁn, JuliÁn Clemente; Ruiz–Contreras, Jesús; Espert, Ángel Nogales

doi:10.1097/01.inf.0000091282.70253.5f

Cited by 89 publications

(22 citation statements)

References 15 publications

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“…In our study, the HAART therapy has allowed for a better cellular immunity due to a significant increase in the count of CD4+ lymphocytes in both age ranges, and such fact was also observed by other authors 4,5,25,26 . This may have been one of the reasons that led the children under HAART, aged bellow 6 years to present lower COM incidence.…”

Section: Chronic Otitis Mediasupporting

confidence: 68%

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

Weber

Pinheiro‐Neto

Miziara

et al. 2006

Rev. Bras. Otorrinolaringol.

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O advento de novas drogas anti-retrovirais como os inibidores de protease provocou mudanças sensíveis na morbidade e mortalidade de pacientes infectados pelo HIV. OBJETIVOS: Avaliar o impacto das novas drogas anti-retrovirais (Highly Active Anti-retroviral Therapy - HAART) na prevalência de otite média crônica em população pediátrica infectada pelo HIV. MÉTODOS: Analisamos os prontuários de 471 crianças com idade entre zero e 12 anos e 11 meses portadoras de HIV atendidas no ambulatório de AIDS de Clínica Otorrinolaringológica do HCFMUSP. As crianças foram divididas em dois grupos, de acordo com a faixa etária: 0 a 5 anos e 11 meses e 6 a 12 anos e 11 meses, e classificadas como portadoras de otite média crônica, baseadas em achados de anamnese, otoscopia, audiometria e imitanciometria. As prevalências de otite média crônica apresentadas e as contagens de linfócitos T CD4+ foram comparadas entre as crianças em uso ou não de HAART. RESULTADOS: Das 459 crianças atendidas, 65 (14,2%) apresentavam otite média crônica. Observamos, nas crianças de 0 a 5 anos e 11 meses que o uso de HAART esteve associado a significante menor prevalência de otite média crônica (p = 0,02), e maior contagem de linfócitos T CD4+ (p < 0,001). CONCLUSÃO: O uso de HAART esteve associado à menor prevalência da forma crônica de otite média entre crianças menores de 6 anos infectadas pelo HIV, provavelmente como conseqüência do aumento promovido na contagem de linfócitos T CD4+.

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Section: Chronic Otitis Mediasupporting

confidence: 68%

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

Weber

Pinheiro‐Neto

Miziara

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…In agreement with our study, it is well established that mortality is generally lower in HIV-infected children on ART compared to those not on ART, with or without TB coinfection. 5,21,22 Our lower mortality figure may be attributed to our HIV programme's policy of prompt screening for TB of all children diagnosed with HIV, and followed by the immediate commencement of ATT prior to early initiation of ART. Our sensitivity analysis examined the worst-case scenario where all LTFU patients were considered to have died.…”

Section: Discussionmentioning

confidence: 95%

Mortality among pulmonary tuberculosis and HIV-1 co-infected Nigerian children being treated for pulmonary tuberculosis and on antiretroviral therapy: a retrospective cohort study

Ebonyi

Oguche

Agbaji

et al. 2016

GERMS

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Background Mortality data, including the risk factors for mortality in HIV-infected children with pulmonary TB (PTB) being treated for PTB and who are on antiretroviral therapy (ART), are scarce in Nigeria. We determined the mortality rate and risk factors for mortality among such children, at the pediatric HIV clinic of the Jos University Teaching Hospital (JUTH) in Jos, Nigeria.Methods We performed a retrospective cohort study on 260 PTB-HIV-1 co-infected children, aged 2 months to 13 years, being treated for PTB and on ART from July 2005 to March 2013. The mortality rate and associated risk factors were determined using multivariate Cox proportional hazards modelling.Results The mortality rate for the study cohort was 1.4 per 100 child-years of follow-up. Median follow-up time was 5.2 years (IQR, 3.5-6.0 years) with total study time being 1159 child-years. The median age of those who died was lower than that of survivors, 1.9 years (IQR, 0.6-3.6 years) versus 3.8 years (IQR, 1.8-6.0 years), p=0.005). The majority of the deaths occurred in males (13, 81.2%), those <5 years of age (14, 87.4%) and those who had severe immunosuppression (11, 68.8%). Risk factors for death were age (with the risk of dying decreasing by 25% for every 1 year increase in age, adjusted hazard ratio ( Conclusion In our clinic setting, mortality among our PTB-HIV co-infected children being treated for PTB and on ART was low. However, those presenting with severe immunosuppression and who are males and very young, should be monitored more closely during follow-up in order to further reduce mortality.

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“…Several studies in Europe and the United States have also demonstrated HAART's effectiveness in reducing child mortality (Essajee et al 1999, Teglas et al 2000, Gortmaker et al 2001, van Rossum et al 2001, Goethebuer et al 2009, Kapogiannis et al 2011, Peacock-Villada et al 2011. In a Spanish cohort, HAART decreased the progression of HIV infection, with an estimated reduction of 43% of the risk of developing AIDS after five years (Granados et al 2003).…”

Section: Discussionmentioning

confidence: 99%

The impact of highly active antiretroviral therapy on the survival of vertically HIV-infected children and adolescents in Belo Horizonte, Brazil

Cardoso

Pinto

Candiani

et al. 2012

Mem. Inst. Oswaldo Cruz

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Impact of highly active antiretroviral therapy on the morbidity and mortality in Spanish human immunodeficiency virus-infected children

Abstract: HAART is associated with a marked decline in the progression to AIDS, improved survival in HIV-1-infected children, reduced incidence of infections and hospitalizations and decreased incidence of some organ-specific complications of HIV.

Cited by 89 publications

References 15 publications

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

Mortality among pulmonary tuberculosis and HIV-1 co-infected Nigerian children being treated for pulmonary tuberculosis and on antiretroviral therapy: a retrospective cohort study

The impact of highly active antiretroviral therapy on the survival of vertically HIV-infected children and adolescents in Belo Horizonte, Brazil

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