Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis

Comper, Sandra Mara; Jardim, Anaclara Prada; Corso, Jeana Torres; Gaça, Larissa Botelho; Noffs, Maria Helena da Silva; Lancellotti, Carmen Lúcia Penteado; Cavalheiro, Ésper A.; Centeno, Ricardo Silva; Yacubian, Elza Márcia Targas

doi:10.1016/j.yebeh.2017.08.013

Cited by 25 publications

(20 citation statements)

References 41 publications

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“…This most likely corresponds to atrophy in the anterior CA1 subfield. Numerous studies, 11,12,14,16‐18,20 but not all previous histopathological investigations,9,10 have reported a correlation between neuronal cell loss in the CA1 subfield and preoperative verbal memory. Studies in nondemented elderly showed an association between verbal memory and hippocampal head size 39 …”

Section: Discussionmentioning

confidence: 92%

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

Postma

Cury

Baxendale

et al. 2020

Annals of Neurology

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Objective Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE), but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface‐shape patterns to verbal and visual learning. Methods We analyzed hippocampal surface shapes on high‐resolution magnetic resonance images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLE patients, and 39 age‐ and sex‐matched healthy volunteers. Results Both left TLE (LTLE) and right TLE (RTLE) patients had lower verbal (LTLE 44 ± 11; RTLE 45 ± 10) and visual learning (LTLE 34 ± 8, RTLE 30 ± 8) scores than healthy controls (verbal 58 ± 8, visual 39 ± 6; p < 0.001). Verbal learning was more impaired the greater the atrophy of the left superolateral hippocampal head. In contrast, visual memory was worse with greater bilateral inferomedial hippocampal atrophy. Postsurgical verbal memory decline was more common in LTLE than in RTLE (reliable change index in LTLE 27% vs RTLE 7%, p = 0.006), whereas there were no differences in postsurgical visual memory decline between those groups. Preoperative atrophy of the left hippocampal tail predicted postsurgical verbal memory decline. Interpretation Memory deficits in TLE are associated with specific morphological alterations of the hippocampus, which could help stratify TLE patients into those at high versus low risk of presurgical or postsurgical memory deficits. This knowledge could improve planning and prognosis of selective epilepsy surgery and neuropsychological counseling in TLE. ANN NEUROL 2020 ANN NEUROL 2020;88:170–182

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Section: Discussionmentioning

confidence: 92%

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

Postma

Cury

Baxendale

et al. 2020

Annals of Neurology

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“…Furthermore, neuronal density in the CA1 was significantly associated with preoperative Immediate and Delayed recall scores in patients undergoing temporal lobectomy ( Baxendale et al, 1998 ). Another study reported that the CA1 is involved in t Immediate and Delayed recall in patients with left hippocampal sclerosis ( Comper et al, 2017 ). Notably, we obtained similar results in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…In those without hippocampal sclerosis, to a lesser degree, auditory Immediate recall was associated with the CA3 and DG, whereas auditory Delayed recall and recognition were more closely related to the fusiform gyrus. In a recent study, the CA1 was implicated in Immediate and Delayed recall of verbal memory in patients with left hippocampal sclerosis, while for patients with right hippocampal sclerosis, the CA1 and epilepsy duration were related to visual memory ( Comper et al, 2017 ). Carlesimo et al (2015) found no significant correlation between hippocampal subfield volumes and Immediate and Delayed recall scores in healthy participants.…”

Section: Introductionmentioning

confidence: 99%

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The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan

Zheng

Cui

Zhang

et al. 2018

Front. Aging Neurosci.

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Background: The hippocampus is an important limbic structure closely related to memory function. However, few studies have focused on the association between hippocampal subfields and age-related memory decline. We investigated the volume alterations of hippocampal subfields at different ages and assessed the correlations with Immediate and Delayed recall abilities.Materials and Methods: A total of 275 participants aged 20–89 years were classified into 4 groups: Young, 20–35 years; Middle-early, 36–50 years; Middle-late, 51–65 years; Old, 66–89 years. All data were acquired from the Dallas Lifespan Brain Study (DLBS). The volumes of hippocampal subfields were obtained using Freesurfer software. Analysis of covariance (ANCOVA) was performed to analyze alterations of subfield volumes among the 4 groups, and multiple comparisons between groups were performed using the Bonferroni method. Spearman correlation with false discovery rate correction was used to investigate the relationship between memory recall scores and hippocampal subfield volumes.Results: Apart from no significant difference in the left parasubiculum (P = 0.269) and a slight difference in the right parasubiculum (P = 0.022), the volumes of other hippocampal subfields were significantly different across the adult lifespan (P < 0.001). The hippocampal fissure volume was increased in the Old group, while volumes for other subfields decreased. In addition, Immediate recall scores were associated with volumes of the bilateral molecular layer, granule cell layer of the dentate gyrus (GC-DG), cornus ammonis (CA) 1, CA2/3, CA4, left fimbria and hippocampal amygdala transition area (HATA), and right fissure (P < 0.05). Delayed recall scores were associated with the bilateral molecular layer, GC-DG, CA2/3 and CA4; left tail, presubiculum, CA1, subiculum, fimbria and HATA (P < 0.05).Conclusion: The parasubiculum volume was not significantly different across the adult lifespan, while atrophy in dementia patients in some studies. Based on these findings, we speculate that volume changes in this region might be considered as a biomarker for dementia disorders. Additionally, several hippocampal subfield volumes were significantly associated with memory scores, further highlighting the key role of the hippocampus in age-related memory decline. These regions could be used to assess the risk of memory decline across the adult lifespan.

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“…Baddeley の提唱した実行系機能(executive function)という説明概念は、記憶だけにとどまらず、複雑な認知処理過程を総称するものとして神経心理学分野でも重宝されてきた (Baddeley, 2012;Hoffmann, Schmeichel, & Baddeley, 2012) 。その定義は研究者によって若干異なるが、簡単に言えば、目的志向的で意識的でない自動的な行動の開始・維持・抑止に関係する処理過程のことであり、脳幹部、皮質下、皮質のネットワークを介して意図や情動に基づいて形成された行動プログラム選択肢を、過去経験や発達過程で学習した価値に基づいて評価し、行動として実行・抑制・制止を決める仕組みである。その神経基盤は人間での脳損傷や動物を対象とする研究から、前頭前野眼窩部(orbitofrontal cortex) 、前頭前野内側部 (medial prefrontal cortex) 、線状体(striatum) 、側座核(nucleus accumbens) 、視床(thalamus)が対応する脳部位であるとされている (Aron, Robbins, & Poldrack, 2004, 2014Curtis, & D'Esposito, 2003 (Burgess & Stuss, 2017;Lezak, 1983;Stuss, 2011;Welsh & Pennington, 1988 Cavalheiro, Centeno, & Yacibian, 2017;Fernandez, Asarnow, Narr, Subotnik, Kuppinger, Foreison, & Nuechiteriein, 2018;Kose, Ikenaga, Yamada, Morimura, Takeda, Omura, Tsuboi, Yamada, Kimura, Kiyonaga, Higaki, Tanaka, & Nakagawa, 2016) 3.1 方法…”

Section: はじめにunclassified

Development of the burden expression suppression questionnaire for Japanese

Hatta

Iwahara

et al. 2018

Ningen kankyougaku kenkyuu

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The purpose of this study was to develop a new questionnaire to assess the burden expressive suppression for Japanese (J-BES) based on the BES by Niermeyer, Franchow & Suchy (2016). In this study 1, 465 upper-middle and older adults filled 20 questionnaire items and two factors, social suppression and personal suppression, were identified by the factor analysis and selected 8 items as J-BES. In study 2, possible relations between J-BES score and D-CAT (representing attention related prefrontal cortex function) and Logical Memory test (representing memory related frontal-temporal cortex function) scores were examined. High J-BES score group participants showed worse D-CAT scores than low J-BES score group participants. These findings seem to support that J-BES has a certain level of test validity.

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Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis

Cited by 25 publications

References 41 publications

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan

Development of the burden expression suppression questionnaire for Japanese

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