Impact of HIV infection on aging and immune status

Blanco, José-Ramón; Negredo, Eugènia; Bernal, Enrique; Blanco, Julià

doi:10.1080/14787210.2021.1848546

Cited by 15 publications

(20 citation statements)

References 159 publications

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“…The life expectancy of persons living with HIV (PLWH) on ART has improved worldwide in recent years [ 127 ]. However, despite effective ART and virologic control, it is well known that HIV causes a persistent low-grade inflammatory and immune activation state [ 128 , 129 , 130 , 131 ]. Inflammation is a key factor in physiological aging (inflammaging) [ 132 ].…”

Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

“…On a mechanistic level, this accelerated aging is thought to occur due to increased immune activation, chronic inflammation, oxidative stress and mitochondrial dysfunction maintained even when HIV viral replication has been suppressed for years [ 96 , 97 , 98 , 99 ]. The causes are multiple and are due, in a direct and indirect way, to HIV infection [ 131 ]. Some HIV proteins (i.e., Nef) induce the secretion of proinflammatory cytokines and chemokines [ 138 ].…”

Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

“…To date, different therapeutic strategies have been explored in PLWH to reduce immune activation and inflammation, but none of them have been fully effective [ 131 ]. These strategies include early ART initiation, ART intensification, the use of anti-inflammatory agents, the rebuilding the gut microbiota system, and so on.…”

Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

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Senotherapeutics in Cancer and HIV

Sánchez-Díaz

Espinosa-Sánchez

Blanco

et al. 2022

Cells

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Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms. In contrast, chronic senescence activation may be responsible for other events such as age-related disorders, HIV and cancer development. Cellular senescence activation can be triggered by different insults. Regardless of the inducer, there are several phenotypes generally shared among senescent cells: cell division arrest, an aberrant shape, increased size, high granularity because of increased numbers of lysosomes and vacuoles, apoptosis resistance, defective metabolism and some chromatin alterations. Senescent cells constitute an important area for research due to their contributions to the pathogenesis of different diseases such as frailty, sarcopenia and aging-related diseases, including cancer and HIV infection, which show an accelerated aging. Hence, a new pharmacological category of treatments called senotherapeutics is under development. This group includes senolytic drugs that selectively attack senescent cells and senostatic drugs that suppress SASP factor delivery, inhibiting senescent cell development. These new drugs can have positive therapeutic effects on aging-related disorders and act in cancer as antitumor drugs, avoiding the undesired effects of senescent cells such as those from SASP. Here, we review senotherapeutics and how they might affect cancer and HIV disease, two very different aging-related diseases, and review some compounds acting as senolytics in clinical trials.

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Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

Section: Senotherapeutics For Hiv Infectionmentioning

confidence: 99%

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Senotherapeutics in Cancer and HIV

Sánchez-Díaz

Espinosa-Sánchez

Blanco

et al. 2022

Cells

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“…HIV-induced changes in immune activation and inflammatory response promote aging even when HIV is suppressed with antiretroviral therapy [ 6 ]. In addition, the toxicity of antiretroviral treatment affects the individual’s chronic low-grade inflammatory phenotype [ 7 ]. Because of these immune change mechanisms, the incidence rates of cardiovascular disease, liver disease, bone disease, kidney disease, cancer, and cognitive decline have been reported to be much higher in people living with HIV than in uninfected people [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

Noh

2022

IJERPH

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There is a lack of evidence regarding the effects of exercise on older individuals living with HIV. This systematic review and meta-analysis examined previous studies on physical activity interventions for people living with HIV aged ≥50 years. The effectiveness of the interventions on various physical and psychological health outcomes was evaluated. Databases used for this review included PubMed, EMBASE, CINAHL, and Cochrane Library CENTRAL. Twelve randomized controlled trials on physical activity interventions for people ≥50 years and living with HIV were included. Standardized mean differences were calculated using random-effect models. All effect sizes were expressed using Cohen’s d values and their 95% confidence intervals (CIs). Physical activity interventions had a significant effect on walking capacity (Cohen’s d: 0.467; 95% CI [0.069, 0.865]). The effect sizes on cardiorespiratory fitness, weight, and health-related quality of life were not significant. These findings suggest that physical activity interventions for people living with HIV aged ≥50 years are effective for the improvement of walking capacity. Further larger and higher-quality studies are required to determine the full effects of physical activity interventions on various health outcomes among older adults with HIV.

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“…11 sVCAM-1 is elevated in persons living with HIV compared to uninfected individuals. 12 In a study done in Indonesia, which included 68 chronically infected HBV patients, it was found that TGF-β1 levels were significantly elevated in patients with HBV infection. 13 TGF-β1 and interleukin-10 (IL-10) are key regulators of immune homeostasis.…”

Section: Introductionmentioning

confidence: 99%

sVCAM-1, and TGFβ1 in chronic phase, chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Hammed

Ahmed

Adam

et al. 2022

EJI

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The outcome for chronic phase (CP) chronic myelogenous leukemia (CML) patients has changed dramatically since the introduction of tyrosine kinase inhibitor (TKI) therapy. We examined the characteristics of CML patients during TKI therapy by determining the plasma concentrations of soluble vascular cell adhesion molecule 1 (sVCAM-1), and transforming growth factor (TGFβ1) biomarkers. The plasma levels of sVCAM-1 and TGFβ1 were measured by ELISA at baseline and after 3 months of TKI treatment. The levels of sVCAM-1, and TGFβ1 were significantly elevated in patients with CML (P< 0.01). Dasatinib treatment was associated with a significant reduction in the levels of these biomarkers (P< 0.01). In conclusion, plasma levels of sVCAM-1 and TGFβ1 could have a role in the pathogenesis of CML and may be used as predictors of hematological and molecular responses to TKIs. A favorable outcome for Dasatinib therapy was observed.

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Impact of HIV infection on aging and immune status

Cited by 15 publications

References 159 publications

Senotherapeutics in Cancer and HIV

Senotherapeutics in Cancer and HIV

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

sVCAM-1, and TGFβ1 in chronic phase, chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

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