2012
DOI: 10.1590/s0102-86502012000700005
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Impact of hypertension in liver regeneration in rats

Abstract: PURPOSE:To determine the impact of hypertension in liver regeneration, in rats by examining gain in liver mass and the replication of hepatocytes and stellate cells. METHODS:Forty Wistar rats were allocated into two groups of twenty, the control and experiment group. The experiment group animals were submitted to induction of renovascular hypertension. A week later, all the animals underwent a partial hepatectomy.Measurements were taken after 24 hours and seven days, when ten animals in each group were euthani… Show more

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“…Intraparenchymal injection was accompanied by localized and well-defined fibrosis, with little systemic repercussion. Vascular hypertension or exclusion and systemic response associated to microcirculatory failure and hepatocyte ischemia must be taken into account to explain the adverse effects found mainly in the Group 4 [24][25][26][27] .…”
Section: ■ Discussionmentioning
confidence: 99%
“…Intraparenchymal injection was accompanied by localized and well-defined fibrosis, with little systemic repercussion. Vascular hypertension or exclusion and systemic response associated to microcirculatory failure and hepatocyte ischemia must be taken into account to explain the adverse effects found mainly in the Group 4 [24][25][26][27] .…”
Section: ■ Discussionmentioning
confidence: 99%