The theoretical aspects, benefits, research contributions, technical recommendations, side effects, limitations, environmental concerns as well as the legislation on the application of phosphogypsum to Brazilian savanna (Cerrado) soils are discussed in this review. It is shown why it is important to apply phosphogypsum to Cerrado soils, and its effect on plant resilience to drought periods. The application of this product may become a main practice in Cerrado soils − a region in which crops as well as pastures are grown − as temperatures rise, and dry periods turn extended, due to climate change. Sulfate, as a component of phosphogypsum, does not leach to groundwater such as in temperate climate soils, turning the use of phosphogypsum environmentally friendly. The phosphogypsum produced in Brazil is a clean by-product of phosphate industry, whose rock source plays an important role providing low trace element and radionuclide contents. It is noteworthy that the Brazilian experience based on phosphogypsum application may work in many tropical soils around the globe, and many populations may be benefited from this technical knowledge.

PURPOSE:To determine the impact of hypertension in liver regeneration, in rats by examining gain in liver mass and the replication of hepatocytes and stellate cells. METHODS:Forty Wistar rats were allocated into two groups of twenty, the control and experiment group. The experiment group animals were submitted to induction of renovascular hypertension. A week later, all the animals underwent a partial hepatectomy.Measurements were taken after 24 hours and seven days, when ten animals in each group were euthanized. Thus, four subgroups were obtained. The livers were excised and sent for histopathological analysis. RESULTS:The control group had a greater gain in liver mass than the experiment group seven days after partial hepatectomy (p=0.0051).The difference in the activate stellate cell count was not statistically significant following analysis after both 24 hours and seven days (p=1.0). A higher number of dividing hepatocytes was observed in the control group seven days after partial hepatectomy (p=0.0014). CONCLUSION:In rats, hypertension had no direct influence on stellate cell replication, but led to a delay in liver mass gain and were shown to be a reduction factor on hepatocyte replication seven7 days after partial hepatectomy.Key words: Hypertension. Liver Regeneration. Rats. RESUMO OBJETIVO:Determinar o impacto da hipertensão arterial sistêmica na regeneração hepática, em ratos, através da análise do ganho de massa hepática e da replicação dos hepatócitos e das células estreladas. MÉTODOS:Alocaram-se 40 ratos Wistar em dois grupos de 20 animais, os grupos controle e experimento. Os do grupo experimento submeteram-se a indução da hipertensão renovascular. Uma semana após, realizou-se hepatectomia parcial em todos os animais.Colheram-se os dados com 24 horas e sete dias, quando dez animais de cada grupo submeteram-se a eutanásia. Assim, obtiveram-se quatro subgrupos. Os fígados foram retirados e enviados para análise histopatológica. RESULTADOS:O grupo controle apresentou maior ganho de massa hepática do que o grupo experimento sete dias após a hepatectomia parcial (p=0,0051). A diferença na contagem das células estreladas ativadas não foi estatisticamente significante nas análises de 24 horas e de sete dias (p=1,0). Um maior número de hepatócitos em divisão foi observado no grupo controle, sete dias após a hepatectomia parcial (p=0,0014). CONCLUSÃO:Em ratos, a hipertensão não teve influência direta sobre a replicação de células estreladas, mas levou ao atraso no ganho de massa hepática e mostrou ser um fator de redução na replicação de hepatócitos sete dias após a hepatectomia parcial.Descritores: Hipertensão. Regeneração Hepática. Ratos. Impact of hypertension in liver regeneration in rats