Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study

Abstract

BackgroundThe aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population.MethodsA total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest.ResultsHT + DM group had higher interventricular septal thickness (IVSd), posterior wall thickness (PWTd), left ventricular mass (LVM), LVM index (LVMI), relative wall thickness (RWT), left atrial diameter (LAD), A wave and lower E wave than HT group (all P < 0.05). The prevalence rates of left ventricular hypertrophy (LVH) and abnormal geometry were statistically different among three groups (P < 0.001) and eccentric hypertrophy was the highest proportion of geometry abnormality. Logistic regression analysis suggested that subjects in HT and HT + DM groups had odds ratio (OR) values of 2.81, 4.41, 2.24 and 3.94, 7.20, 2.38 for LVH, concentric hypertrophy and eccentric hypertrophy in the total population, respectively, compared to control group. When compared with HT group, those in HT + DM group had approximately 1.40-, 1.61- and 1.38-, 1.71-fold increased risk for LVH and concentric hypertrophy in the total and female population separately, but no association of HT + DM with LVH and abnormal geometrical patterns was found in men.ConclusionsThis study demonstrated that, to varying degrees, hypertension was associated with LV remodeling in rural Chinese population, and this risk association was obviously increased for LVH and concentric hypertrophy when accompanied by diabetes, especially for women.

Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study

“…In the HyperGEN study comprising only hypertensive subjects, diabetes was independently associated to increased LV mass [ 35 ]. A recent Chinese study suggested additive effects of diabetes and hypertension to LV remodeling [ 36 ]. Although blood pressure reduction appears to be an effective way of lowering the risk of cardiovascular disease in hypertensive patients with increased LV mass, [ 37 ] these treatments do not seem to be as effective in patients with diabetes [ 38 ].…”

Serum matrix metalloproteinase-9 is a valuable biomarker for identification of abdominal and thoracic aortic aneurysm: a case-control study

“…Hypertension was defined as having a systolic blood pressure (SBP) ≥ 140 mmHg and/or having a diastolic blood pressure (DBP) ≥90 mmHg and/or being under antihypertensive treatment. Diabetes was defined as fasting serum glucose (FPG) ≥7 mmol/L (126 mg/dL) and (or) being on treatment for diabetes [ 12 ]. Hyperlipidemia was defined as serum total cholesterol (TC) ≥6.22 mmol/L (240 mg/dL), or serum triglyceride (TG) ≥2.26 mmol/L (200 mg/dL), or serum low-density lipoprotein cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL) [ 13 ].…”

Association of Microalbuminuria with Abnormal Left Ventricular Geometry Patterns in Nigerian Normotensive Type 2 Diabetic Patients

“…In this study that focused on normotensive type 2 diabetics, we also observed that PWTd, IVSTd and LVID progressively increased from control group to microalbuminuric group, which resulted in the increased LVM, LVMI and RWT, thereby influencing the LV geometry remodeling. Diabetes has been implicated in the pathogenesis of cardiovascular abnormalities such as higher and lower LVM, more concentric left ventricular geometry remodeling and a lower myocardial function independent of age, sex, body size and arterial blood pressure [3,6,[21][22]. These cardiovascular abnormalities are known to predict higher rates of cardiovascular events in both asymptomatic and symptomatic subjects and also contribute in part to the high rates of coronary heart disease and heart failure observed among diabetic patients [23,24].…”

“…Diabetes mellitus (DM) is associated with diverse cardiovascular conditions such as myocardial infarction and heart failure (HF), which are the leading causes of diabetesrelated morbidity and mortality [1,2]. Previous studies elsewhere [3][4][5] and in Nigeria [6] have demonstrated left ventricular geometry remodeling and dysfunction in diabetics, supporting the existence of diabetic cardiomyopathy (DMCMP). The Framingham Heart Study showed that the frequency of HF is twice as high in diabetic men and five times higher in diabetic women compared with age-matched controls, and that this increased incidence of HF persisted despite correction for age, hypertension, obesity, hypercholesterolaemia and coronary artery disease (CAD) [7].…”