Impact of <i>PSCA</i> gene polymorphisms in modulating gastric cancer risk in the Chinese population

Yan, Kangpeng; Wu, Kun; Lin, Chao; Jie, Zhigang

doi:10.1042/bsr20181025

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Since PSCA is expressed in the gastric gland isthmus, anatomical factors may influence the location of GC. In this meta-analysis, the effect of PSCA rs2294008 on non-cardia gastric cancer was significantly higher than that of cardia gastric cancer, which was consistent with the results of previous studies (32,37). Similarly, the Lauren classification analysis showed that the disease susceptibility of the diffuse type was higher than that of the intestinal type.…”

Section: Discussionsupporting

confidence: 91%

An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis

Zhao²,

Si³

et al. 2022

Front. Gastroenterol.

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Studies have confirmed that prostate stem cell antigen (PSCA) rs2294008 C>T polymorphism is related to gastric cancer susceptibility, but some studies have reached the opposite conclusion. In this meta-analysis, we attempted to clear up these differences and explore the relationship between the different factors that influence susceptibility to gastric cancer. Studies with publication dates that preceded 16 April 2022 were selected from PubMed, Springer, EMBASE, and Web of Science, and the relationship between risk models and gastric cancer was analyzed by odds ratios (ORs) and 95% confidence intervals. Consequently, it was confirmed that PSCA rs2294008 polymorphism leads to an increased risk of gastric cancer. Subgroup analysis found that individuals with diffuse gastric cancer, non-cardia gastric cancer, Helicobacter pylori (HP)-positive or who are from the white or Asian population faced an increased susceptibility to gastric cancer. Those from the white populations faced significantly higher risks than Asians, and the association of PSCA with gastric cancer could be significantly increased by genome-wide association analysis. However, the conclusion that smoking reduces susceptibility to gastric cancer appears to be abnormal. Further prospective investigations that involve smoking and have a larger sample size are required.

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Section: Discussionsupporting

confidence: 91%

An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis

Zhao²,

Si³

et al. 2022

Front. Gastroenterol.

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“…The PSCA polymorphism is associated with high expression of PSCA in cancer patients [ 61 ]. The T allele of PSCA rs2294008 could decrease the transcriptional activity of the PSCA promoter in gastric cell lines [ 62 ]. The rs2976392 G>A and rs2294008 C>T polymorphisms are the most widely studied polymorphisms in the PSCA , and have been proved to be associated with an increased risk of gastric cancer [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population

Duan

Song

Shi

et al. 2021

Aging

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To summarize and assess the credibility and strength of non-genetic factors and genetic variation on gastric cancer risk, we performed a field synopsis and meta-analysis to identify the risk of gastric cancer in Chinese population. Cumulative evidence was graded according to the Venice criteria, and attributable risk percentage ( ARP ) and population attributable risk percentage ( PARP ) were used to evaluate the epidemiological effect. A total of 956 studies included non-genetic (404 studies) and genetic factors (552 studies) were quantified, and data on 1161 single nucleotide polymorphisms (SNPs) were available. We identified 14 non-genetic factors were significantly associated with gastric cancer risk. For the analysis of time trends, H. pylori infection rate in gastric cancer and population showed a downward trend. Meanwhile 22 variants were identified significantly associated with gastric cancer: 3 ( PLCE1 rs2274223, PSCA rs2976392, MUC1 rs4072037) were high and 19 SNPs were intermediate level of summary evidence, respectively. For non-genetic factors, the top three for ARP were 54.75% (pickled food), 65.87% (stomach disease), and 49.75% (smoked and frying). For PARP were 34.22% (pickled food), 34.24% (edible hot food) and 23.66%( H. pylori infection). On the basis of ARP and PARP associated with SNPs of gastric cancer, the top three for ARP were 53.91% ( NAT2 , rs1799929),53.05% ( NAT2 phenotype), and 42.85% ( IL-10 , rs1800896). For PARP (Chinese Han in Beijing) were 36.96% ( VDR , rs731236), 25.58% ( TGFBR2 , rs3773651) and 20.56% ( MUC1 , rs4072037). Our study identified non-genetic risk factors and high-quality biomarkers of gastric cancer susceptibility and their contribution to gastric cancer.

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“…Based on a study, rs2294008CT and rs2294008CT + TT can increase the risk of gastric cancer in the Chinese population (in young people, non-smokers, non-alcoholics, men and non-cardia patients). The possible mechanism of action for this polymorphism is that this variant reduces the transcriptional activity of the PSCA upstream fragment [ 56 , 83 ]. It was found that the rs2294008 T allele resulted in a significant reduction in transcriptional activity of the PSCA promoter in gastric cell lines [ 32 ].…”

Section: Psca Expression and Polymorphisms In Different Cancersmentioning

confidence: 99%

“…The rs2976392G > A variant is also associated with an increased risk of gastric cancer, but its mechanism of action is unclear. This variant has a strong linkage disequilibrium with rs2294008, which could justify its function [ 83 ]. rs2294008 variant is more associated with diffuse-type gastric cancer than intestinal type in Korean and Japanese populations.…”

Section: Psca Expression and Polymorphisms In Different Cancersmentioning

confidence: 99%

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

Nayerpour Dizaj,

Doustmihan,

Sadeghzadeh Oskouei

et al. 2024

Cancer Cell Int

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One of the contributing factors in the diagnosis and treatment of most cancers is the identification of their surface antigens. Cancer tissues or cells have their specific antigens. Some antigens that are present in many cancers elicit different functions. One of these antigens is the prostate stem cell antigen (PSCA) antigen, which was first identified in the prostate. PSCA is a cell surface protein that has different functions in different tissues. It can play an inhibitory role in cell proliferation as well as a tumor-inducing role. PSCA has several genetic variants involved in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship with clinical features can provide more information on diagnosis and treatment of patients with cancers. Most studies on the PSCA have focused on prostate cancer. While it is also expressed in other cancers, little attention has been paid to its role as a valuable diagnostic, prognostic, and therapeutic tool in other cancers. PSCA has several genetic variants that seem to play a significant role in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship and variants with clinical features can be beneficial in concomitant cancer therapy and diagnosis, as theranostic tools. In this study, we will review the alteration of the PSCA expression and its polymorphisms and evaluate its clinical and theranostics significance in various cancers.

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Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population

Cited by 8 publications

References 24 publications

An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis

An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis

Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

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