Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes

Streitbürger, Daniel Paolo; Pampel, André; Krueger, Gunnar; Lepsien, Jöran; Schroeter, Matthias L.; Mueller, Karsten; Möller, Harald E.

doi:10.1016/j.neuroimage.2013.10.051

Cited by 41 publications

(42 citation statements)

References 42 publications

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“…The acquisition sequence is another source of variability that is often underestimated. Acquisition sequence includes different parameters such as image-to-noise ratio and uniformity, which are known to affect tissue classification leading to different results (Tardiff et al, 2009;Streitbürger et al, 2014).…”

Section: Methodological Factors Influencing the Results Of A Vbm Studymentioning

confidence: 99%

False positive rates in Voxel-based Morphometry studies of the human brain: Should we be worried?

Scarpazza

Tognin

Frisciata

et al. 2015

Neuroscience & Biobehavioral Reviews

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Voxel-based Morphometry (VBM) is a widely used automated technique for the analysis of neuroanatomical images. Despite its popularity within the neuroimaging community, there are outstanding concerns about its potential susceptibility to false positive findings. Here we review the main methodological factors that are known to influence the results of VBM studies comparing two groups of subjects. We then use two large, open-access data sets to empirically estimate false positive rates and how these depend on sample size, degree of smoothing and modulation. Our review and investigation provide three main results: (i) when groups of equal size are compared false positive rate is not higher than expected, i.e. about 5%; (ii) the sample size, degree of smoothing and modulation do not appear to influence false positive rate; (iii) when they exist, false positive findings are randomly distributed across the brain. These results provide reassurance that VBM studies comparing groups are not vulnerable to the higher than expected false positive rates that are evident in single case VBM.

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Section: Methodological Factors Influencing the Results Of A Vbm Studymentioning

confidence: 99%

False positive rates in Voxel-based Morphometry studies of the human brain: Should we be worried?

Scarpazza

Tognin

Frisciata

et al. 2015

Neuroscience & Biobehavioral Reviews

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show abstract

“…Images should be acquired in a reasonably short period because even a scanner upgrade may influence the results [57], which may be a problem for large cohorts, and even more for longitudinal studies. The coil used may also influence the sensitivity of the method, and results obtained with a 32-channel coil generally outperformed those obtained with a 12-channel coil [58]. The voxel size directly influences the spatial resolution of the difference that can be detected [58].…”

Section: Discussionmentioning

confidence: 99%

Desperately seeking grey matter volume changes in sleep apnea: A methodological review of magnetic resonance brain voxel-based morphometry studies

Celle

Delon‐Martin

Roche

et al. 2016

Sleep Medicine Reviews

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“…Evidence before this study 2 We searched PubMed for reports on associations between blood pressure (BP) and grey 3 matter volumes (GMV) in young adults by use of the MeSH terms [hypertension OR blood 4 pressure] AND [atrophy OR grey matter OR gray matter OR brain volume] and no language 5 or date restrictions. We found a systematic review and meta-analysis from 2013 which 6 identified 28 studies that investigated associations of higher BP with GMV across ages.…”

Section: Research In Contextmentioning

confidence: 99%

“…In 2015, the global prevalence of HTN, i.e. raised blood 65 pressure (BP) at or above levels of systolic 140 or diastolic 90 mmHg was around 22%, 66 affecting 1.13 billion adults worldwide 2 . It is expected that the global number of persons with 67 HTN increases with population growth and aging 3 .…”

mentioning

confidence: 99%

Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults

Schaare

Masouleh

Beyer

et al. 2017

Preprint

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Research in Context 1Evidence before this study 2We searched PubMed for reports on associations between blood pressure (BP) and grey 3 matter volumes (GMV) in young adults by use of the MeSH terms [hypertension OR blood 4 pressure] AND [atrophy OR grey matter OR gray matter OR brain volume] and no language 5 or date restrictions. We found a systematic review and meta-analysis from 2013 which 6 identified 28 studies that investigated associations of higher BP with GMV across ages. In 7 the majority of studies, higher BP or hypertension was associated with lower total or regional 8 GMV. Qualitatively, these reductions were predominant in frontal and (medial) temporal 9 lobes. The meta-analysis revealed consistent reductions in hippocampal volumes with high 10 BP/hypertension across studies. However, none of the reports investigated BP-GMV 11 associations in young adults, i.e. younger than 40 years of age. 12 Added value of this study 13In this image-based meta-analysis of four previously unpublished cross-sectional studies that 14 included 423 healthy young adults in total, resting BP ≥120/80 mmHg was associated with 15 lower grey matter volume in several brain regions, including frontal, parietal and subcortical 16 structures (including hippocampus). Our study suggests that subtle pressure-related brain 17 alterations can be observed before 40 years of age and in ranges where BP is still 18 considered "normal" by current guidelines for the management of hypertension. 19 Implications of all the available evidence 20Our study is the first to show that BP-associated grey matter alterations emerge continuously 21 across the range of BP and earlier in adulthood than previously assumed. Elevated BP is 22 globally highly prevalent and an important risk factor for cerebrovascular disease and overall 23 health loss. Our results suggest that treating hypertension or maintaining a lower BP in early 24 adulthood might be essential for preventing the pathophysiological cascade of asymptomatic 25 cerebrovascular disease to symptomatic end-organ damage, such as stroke and dementia. 26International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint . http://dx.doi.org/10.1101/239160 doi: bioRxiv preprint first posted online Dec. 24, 2017; 3In light of our results, large-scale prospective brain imaging studies should include young 27 adults to investigate whether brain changes related to sub-hypertensive BP in early 28 adulthood could serve as early biomarkers for subsequent development of cerebrovascular 29 disease later in life. Such data would provide evidence for future recommendation guidelines 30 for the management of elevated BP in young adults and for the prevention of 31 cerebrovascular disease at older ages. Our results also speak in favor of considering 32 individual BP levels as continuous measures -in addition to a categorical cut-off -which 33 could facilitate the init...

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Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes

Cited by 41 publications

References 42 publications

False positive rates in Voxel-based Morphometry studies of the human brain: Should we be worried?

False positive rates in Voxel-based Morphometry studies of the human brain: Should we be worried?

Desperately seeking grey matter volume changes in sleep apnea: A methodological review of magnetic resonance brain voxel-based morphometry studies

Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults

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