Impact of injections during diagnostic coronary arteriography on coronary patency in the setting of acute myocardial infarction from the TIMI trials

Gibson, C. Michael; Anshelevich, Michael; Murphy, Sabina A.; Luu, Lily; Hynes, Colin; Kliris, Jen; Kermgard, Sarah; Otten, Mathew H.C; Antman, Elliott M.; Cannon, Christopher P.; Braunwald, Eugene

doi:10.1016/s0002-9149(00)01248-0

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…In a study of 78 consecutive normal coronary arteries of 78 patients in the absence of acute myocardial infarction, mean corrected TFC for normal coronary arteries was 21 ± 3.1 frames, yielding a 95% confidence interval for normal flow of (15,27) frames. The TIMI frame count for the right coronary artery (n = 38) was 20.4 ± 3.0 frames; for the circumflex artery (n = 21) it was 22.2 ± 4.1 frames.…”

Section: Normal Reference Values At 30 Frames Per Secondmentioning

confidence: 99%

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Kunadian

Harrigan

Zorkun

et al. 2008

J Thromb Thrombolysis

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Section: Normal Reference Values At 30 Frames Per Secondmentioning

confidence: 99%

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Kunadian

Harrigan

Zorkun

et al. 2008

J Thromb Thrombolysis

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“…7 A variety of technical and physiological variables impact the CTFC. 20,[33][34][35][36] Use of a power injector to change the force of injection (cc/sec) from the 10th to the 90th percentile of human injection rates lowers the CTFC by only 2 frames, 33 nitrate administration significantly increases the CTFC by Ϸ6 frames (PϽ0.001), 20 dye injection at the beginning of diastole significantly decreases the CTFC by 3 to 6 frames, 20 and increasing the heart rate by 20 bpm significantly decreases the CTFC by Ϸ5 frames (PϽ0.001). 20 It is for this reason that administration of nitrates is often standardized in trials assessing the CTFC as an end point.…”

Section: Technical Factors Influencing the Ctfcmentioning

confidence: 99%

“…20 It is for this reason that administration of nitrates is often standardized in trials assessing the CTFC as an end point. The mechanical force of injection alone in a closed artery following fibrinolytic therapy will open Ϸ10% of closed arteries, 34 but the dye type used for injection is not associated with changes in the CTFC. 35 …”

Section: Technical Factors Influencing the Ctfcmentioning

confidence: 99%

Coronary and Myocardial Angiography

2004

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A ngiographic assessment of epicardial coronary artery blood flow has played a pivotal role in our understanding of the "time-dependent open artery hypothesis" and in the evaluation of reperfusion strategies over the past 2 decades. [1][2][3][4][5][6][7][8] It has become increasingly apparent, however, that clinical outcomes are not only associated with angiographic flow in the epicardial artery, but also with angiographic flow in the myocardium. 9 -13 To this end, the goal of reperfusion therapies has shifted to include reperfusion downstream at the level of capillary bed, and it might be more appropriate that the hypothesis now be termed "the time dependent open artery and open microvascular hypothesis." The goal of this article is to review angiographic methods used to evaluate myocardial ischemia and infarction and to discuss the insights into the pathophysiology of acute coronary syndromes provided by these angiographic indexes of coronary artery blood flow and myocardial perfusion.

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“…We must underline that these samples contain noises from different sources [8] (unprecise recording, unprecise fluid injection [6], [7] x-ray device's auto-intensity regulation, image processing bugs [15]) and our effort in figuring out suitable noise models was a fool's errand. …”

Section: Results On the Initial Samplesmentioning

confidence: 99%

“…The digital substraction angiography [14] used in medical surgery is one kind of an image recording and processing method where panoramic x-ray images are taken while contrastive x-ray fluid [6] is injected into the patient's heart's main arteria. The goal is to estimate the probability of cardiac muscle regeneration of a patient who has recently survived a stroke, being dead blood cells removed by means of a surgery intervention.…”

Section: Problem Addressedmentioning

confidence: 99%

Parameter Estimation of Flow-Measurement in Digital Angiography

Veress

Csendes

2011

Acta Cybern

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The purpose of angiographic procedures used in cardiovascular interventions is to classify the patient's potential of regeneration after strokes caused by dead blood cells in the main arteria. The flow of blood into heart's capillaries is measured using x-ray radiometry with contrastive fluids.Our task was to fit a 5-parameter Gamma function to the intensity samples extracted from the x-ray angiogramms. The estimation of this function's parameters is hard given that the raw data set is heavily polluted with several different types of noise.Our complete solution has four main parts which have also been successfully verified and validated. First, we propose a solution for eliminating the noise by applying a specially designed moving window Gauss filter. Secondly, we have designed an algorithm for computing a good initial guess for the Levenberg-Marquardt optimizer in order to achieve the required precision. Third, an algorithm is proposed for selecting significant points on the smoothed data set with an interval-based classification method. Finally we apply the LM algorithm to compute the solutions in a nonlinear least squares way.We have also designed an algorithm which can be used for comparing different results and assign goodness values based on their residuals. This method has been used for measuring improvements during the development.We must emphasize that the proposed algorithms are distinct, they can be used in other applications together or separately since they are generally applicable, they do not depend on specialties of specific presented application.

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Impact of injections during diagnostic coronary arteriography on coronary patency in the setting of acute myocardial infarction from the TIMI trials

Cited by 6 publications

References 10 publications

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Coronary and Myocardial Angiography

Parameter Estimation of Flow-Measurement in Digital Angiography

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