Impact of inspiratory muscle strength on exercise capacity after lung transplantation

Sato, Tatsuya; Satô, Susumu; Oshima, Yasuhiro; Yoshioka, Yumiko; Hamada, Ryota; Nankaku, Manabu; Ikeda, Masaki; Nakajima, Daisuke; Chen‐Yoshikawa, Toyofumi F.; Date, Hiroshi; Matsuda, Shinya; Tabira, Kazuyuki

doi:10.1002/pri.1951

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…This would positively influence the candidate’s health-related quality of life (HRQOL) ( 35 ). Pre-transplant rehabilitative interventions mainly focus on motor and breathing exercises ( 36 ) and have been integrated into an education program. Lung transplant candidates should be encouraged to attend pre-transplant rehabilitation to preserve and improve their HRQOL ( 37 ).…”

Section: Resultsmentioning

confidence: 99%

A narrative review on the management of patients awaiting lung transplantation in Japan

Suzuki,

Yoshino

2023

J Thorac Dis

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Background and Objective The number of lung transplantations performed in Japan is increasing, and post-transplant outcomes are relatively favorable. A major concern is the extremely long waiting time and the high mortality rate on the waitlist. The management of patients before transplantation is very important and essential for further improvement of outcomes. In this review, we summarize the management of patients awaiting lung transplantation in Japan. Methods A literature search was conducted via PubMed in November 2022 using the following keywords: lung transplantation, waiting, management, recipient, and Japan. Peer-reviewed academic journal articles published in English were also included. Key Content and Findings A growing number of studies have evaluated the management of pre-transplant patients. This includes infection control, vaccination, respiratory disease-specific treatment, malignancy, nutrition, rehabilitation, psychosocial assessment, and health-related quality of life (HRQOL) for patients on the waitlist. Each is important, and various evaluation methods and strategies to improve outcomes have been reported. Conclusions Proper and multifaceted management of pretransplant patients is extremely important to reduce the mortality of candidates for lung transplantation. Integrated management is crucial to the success and survival of lung transplant recipients.

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Section: Resultsmentioning

confidence: 99%

A narrative review on the management of patients awaiting lung transplantation in Japan

Suzuki,

Yoshino

2023

J Thorac Dis

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“…In older stable COPD patients (forced expiratory volume in 1 s 63.0 ± 26.4% of predicted), MIP is an influencing factor on low-intensity physical activity [28]. Improvements in MIP in recipients (mean age: 44.8 years) who underwent lung transplantation may impact the recovery of exercise capacity in the early phase after lung transplantation [29]. The diaphragm plays a key role in modulating cardiovascular hemodynamics, and heart failure is associated with diaphragmatic dysfunction [30 ▪ ].…”

Section: Respiratory Sarcopenia and Physical And Nutritional Statusmentioning

confidence: 99%

Definition, diagnosis, and treatment of respiratory sarcopenia

Miyazaki,

Tamaki,

Wakabayashi

et al. 2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Skeletal muscle weakness and wasting also occurs in the respiratory muscles, called respiratory sarcopenia. Respiratory sarcopenia may lead to worse clinical indicators and outcomes. We present a novel definition and diagnostic criteria for respiratory sarcopenia, summarize recent reports on the association between respiratory sarcopenia, physical and nutritional status, and clinical outcomes, and provide suggestions for the prevention and treatment of respiratory sarcopenia. Recent findings Recently, a novel definition and diagnostic criteria for respiratory sarcopenia have been prepared. Respiratory sarcopenia is defined as a condition in which there is both low respiratory muscle strength and low respiratory muscle mass. Respiratory muscle strength, respiratory muscle mass, and appendicular skeletal muscle mass are used to diagnose respiratory sarcopenia. Currently, it is challenging to definitively diagnose respiratory sarcopenia due to the difficulty in accurately determining low respiratory muscle mass. Decreased respiratory muscle strength and respiratory muscle mass are associated with lower physical and nutritional status and poorer clinical outcomes. Exercise interventions, especially respiratory muscle training, nutritional interventions, and their combinations may effectively treat respiratory sarcopenia. Preventive interventions for respiratory sarcopenia are unclear. Summary The novel definition and diagnostic criteria will contribute to promoting the assessment and intervention of respiratory sarcopenia.

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“…As a preoperative CT‐based assessment of paraspinal muscles before lung transplantation, a decrease in muscle mass and quality affects the course of postoperative muscle mass recovery and is associated with prognosis and chronic lung allograft dysfunction 34 . Conversely, MIP improves after lung transplantation from a decreased preoperative status and is consequently associated with improved lung volume, following improvement of exercise tolerance 86 . Therefore, MIP is an important determinant of exercise tolerance in addition to a lower extremity strength after lung transplantation.…”

Section: Diseases and Respiratory Sarcopeniamentioning

confidence: 99%

“…34 Conversely, MIP improves after lung transplantation from a decreased preoperative status and is consequently associated with improved lung volume, following improvement of exercise tolerance. 86 Therefore, MIP is an important determinant of exercise tolerance in addition to a lower extremity strength after lung transplantation.…”

Section: Outcomementioning

confidence: 99%

“…More than half of the patients have interstitial lung disease in lung transplantation. Lung transplantation does not guarantee disease remission and requires multifaceted and sustained intervention, and there are reports on muscle strength and mass assessment in lung transplant recipients 86 . In muscle mass assessment in lung transplant recipients, there is a significant decrease in muscle mass before lung transplantation, with an average decrease in the paraspinal muscle of more than 20% compared with healthy donors 87 …”

Section: Diseases and Respiratory Sarcopeniamentioning

confidence: 99%

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Respiratory sarcopenia: A position paper by four professional organizations

Satô

Miyazaki

Tamaki

et al. 2022

Geriatrics Gerontology Int

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We defined respiratory sarcopenia as a coexistence of respiratory muscle weakness and decreased respiratory muscle mass. Although respiratory muscle function is indispensable for life support, its evaluation has not been included in the regular assessment of respiratory function or adequately evaluated in clinical practice. Considering this situation, we prepared a position paper outlining basic knowledge, diagnostic and assessment methods, mechanisms, involvement in respiratory diseases, intervention and treatment methods, and future perspectives on respiratory sarcopenia, and summarized the current consensus on respiratory sarcopenia. Respiratory sarcopenia is diagnosed when respiratory muscle weakness and decreased respiratory muscle mass are observed. If respiratory muscle mass is difficult to measure, we can use appendicular skeletal muscle mass as a surrogate. Probable respiratory sarcopenia is defined when respiratory muscle weakness and decreased appendicular skeletal muscle mass are observed. If only respiratory muscle strength is decreased without a decrease in respiratory function, the patient is diagnosed with possible respiratory sarcopenia. Respiratory muscle strength is assessed using maximum inspiratory pressure and maximum expiratory pressure. Ultrasonography and computed tomography are commonly used to assess respiratory muscle mass; however, there are insufficient data to propose the cutoff values for defining decreased respiratory muscle mass. It was jointly prepared by the representative authors and authorized by the Japanese Society for Respiratory Care and Rehabilitation,

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Impact of inspiratory muscle strength on exercise capacity after lung transplantation

Cited by 6 publications

References 35 publications

A narrative review on the management of patients awaiting lung transplantation in Japan

A narrative review on the management of patients awaiting lung transplantation in Japan

Definition, diagnosis, and treatment of respiratory sarcopenia

Respiratory sarcopenia: A position paper by four professional organizations

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