Impact of Intensity-Modulated Radiotherapy on Health-Related Quality of Life for Head and Neck Cancer Patients: Matched-Pair Comparison with Conventional Radiotherapy

Gräff, P.; Lapeyre, M.; Désandes, Emmanuel; Ortholan, C.; Bensadoun, René-Jean; Alfonsi, M.; Maingon, P.; Giraud, P.; Bourhis, Jean; Marchesi, V.; Mège, Alice; Peiffert, D.

doi:10.1016/j.ijrobp.2006.11.012

Cited by 122 publications

(76 citation statements)

References 35 publications

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“…It is only 5% for those given intensity modulated radiotherapy as patients treated with brachytherapy received a lower dose in masticatory muscles. 6,21 No statistically significant difference was found between those who did or did not have an inclusion of their muscles of mastication in the radiation field which could be attributed to our small sample size. It has been vastly reported that the irradiation of the masseter and pterygoid muscles appears critical in the development of trismus.…”

Section: Discussionmentioning

confidence: 80%

Trismus in oral cancer patients undergoing surgery and radiotherapy

Agarwal

Kumar

2016

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 80%

Trismus in oral cancer patients undergoing surgery and radiotherapy

Agarwal

Kumar

2016

Journal of Oral Biology and Craniofacial Research

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“…IMRT results in better dose conformation to the PTV and improved sparing of adjacent uninvolved normal tissues compared with conventional radiotherapy. Numerous studies showed a reduction in the incidence and severity of xerostomia following parotid-sparing IMRT [19][20][21][22][23][24][25][26][27][28][29][30], with post-treatment recovery of saliva production and resultant improvement in patient-reported quality of life [31]. Three randomised controlled trials comparing parotid-sparing IMRT and conventional radiotherapy were reported [12,32,33].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Interobserver variation in parotid gland delineation: a study of its impact on intensity-modulated radiotherapy solutions with a systematic review of the literature

Loo

Martin²,

Smith³

et al. 2012

The British Journal of Radiology

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Objectives: This study evaluates the interobserver variation in parotid gland delineation and its impact on intensity-modulated radiotherapy (IMRT) solutions. Methods: The CT volumetric data sets of 10 patients with oropharyngeal squamous cell carcinoma who had been treated with parotid-sparing IMRT were used. Four radiation oncologists and three radiologists delineated the parotid gland that had been spared using IMRT. The dose-volume histogram (DVH) for each study contour was calculated using the IMRT plan actually delivered for that patient. This was compared with the original DVH obtained when the plan was used clinically. Results: 70 study contours were analysed. The mean parotid dose achieved during the actual treatment was within 10% of 24 Gy for all cases. Using the study contours, the mean parotid dose obtained was within 10% of 24 Gy for only 53% of volumes by radiation oncologists and 55% of volumes by radiologists. The parotid DVHs of 46% of the study contours were sufficiently different from those used clinically, such that a different IMRT plan would have been produced. Conclusion: Interobserver variation in parotid gland delineation is significant. Further studies are required to determine ways of improving the interobserver consistency in parotid gland definition.

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“…To survey patients' quality of life by EORTC QLQ-C30 score, score of patients' physical function is 93.5±9.6 points, general health status scores 78.9±18 points, cognitive function scores 78.3±22.6 points, in symptom field score of insomnia is 21.5±24.5 points, affection of financial status scores 22.2±29.5 points, scores of the survey of this research is close to score of quality of life of head and neck cancer patients, after treatment of IMRT by the survey of scholars abroad, while factors like regional and cultural differences should be considered (Graff et al, 2007). We achieve invigorative result which is of similar or even better curative effect to intensity modulated radiation therapy, and with no obvious increase of incidence rate of radiation brain injury and aggravation of its severity, which requires long-time follow-up to prove.…”

Section: Discussionmentioning

confidence: 58%

Preliminary Results of a Phase I/II Study of Simultaneous Boost Irradiation Radiotherapy for Locally Advanced Nasopharyngeal Carcinoma

Xiang

Wang²,

Xu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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7%) showing partial remission.The most frequently observed acute toxicities during the concurrent chemoradiotherapy were mucositis and leucopenia. Four patients (6.9%) had RTOG grade 3 mucositis, whereas four patients (6.9%) had grade 3 leucopenia. No patient had grade 4 acute toxicity. Three (5.17%) of the patients exhibited injury to the brain on routine MRI examination, with a median observation of 32 months (range, 25-42months). All of them were RTOG grade 0. The 3-year overall, regional-free and distant metastasis-free survival rates were 85%, 94% and 91%, respectively. Conclusion: Simultaneous boost irradiation radiotherapy is feasible in patients with locally advanced nasopharyngeal carcinoma. The results showed excellent local control and overall survival, with no significant increase the incidence of radiation brain injury or the extent of damage. A larger population of patients and a longer follow-up period are needed to evaluate ultimate tumor control and late toxicity.

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Impact of Intensity-Modulated Radiotherapy on Health-Related Quality of Life for Head and Neck Cancer Patients: Matched-Pair Comparison with Conventional Radiotherapy

Cited by 122 publications

References 35 publications

Trismus in oral cancer patients undergoing surgery and radiotherapy

Trismus in oral cancer patients undergoing surgery and radiotherapy

Interobserver variation in parotid gland delineation: a study of its impact on intensity-modulated radiotherapy solutions with a systematic review of the literature

Preliminary Results of a Phase I/II Study of Simultaneous Boost Irradiation Radiotherapy for Locally Advanced Nasopharyngeal Carcinoma

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