Impact of intercurrent respiratory infections on lung health in infants born &lt;29 weeks with bronchopulmonary dysplasia

Taylor, Jane B.; Nyp, Michael F.; Norberg, Michael; Dai, H; Escobar, Hugo Murua; Ellerbeck, Edward F.; Truog, William E.

doi:10.1038/jp.2013.152

Cited by 6 publications

(5 citation statements)

References 33 publications

(47 reference statements)

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“…31 Given the underlying pulmonary insufficiency that characterizes lung function in infants with established BPD, 32,33 exposure to RVIs can cause major short-and long-term respiratory morbidities. For example, Taylor et al 5 showed that among patients with moderate or severe BPD, intercurrent RVIs during the initial NICU hospitalization have negative short-term impacts and are independently associated with an increased odds of oxygen, diuretic, and inhaled corticosteroid use. Of note, we found a marked reduction on the burden of inhospital rhino/enterovirus RVIs (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…2 Exposure to respiratory viral infections (RVI) is an important contributor to respiratory morbidity in early childhood in preterm infants, 3 and in particular former preterm infants with established BPD. 4,5 Among patients with BPD, RVIs may first occur in the neonatal intensive care unit (NICU) [6][7][8] and are associated with increased length of stay, severe disease course, unnecessary exposure to antibiotics, nosocomial viral outbreaks in the NICU, and death. 7 Though nosocomial RVIs in the NICU are relatively infrequent, multiple reports suggest that viral transmission to infants may occur in the setting of routine interactions with medical staff, families, and visitors.…”

Section: Introductionmentioning

confidence: 99%

“…Despite preventative efforts, the incidence of BPD is increasing due to the increased survival of extremely preterm infants 2 . Exposure to respiratory viral infections (RVI) is an important contributor to respiratory morbidity in early childhood in preterm infants, 3 and in particular former preterm infants with established BPD 4,5 . Among patients with BPD, RVIs may first occur in the neonatal intensive care unit (NICU) 6–8 and are associated with increased length of stay, severe disease course, unnecessary exposure to antibiotics, nosocomial viral outbreaks in the NICU, and death 7 .…”

Section: Introductionmentioning

confidence: 99%

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In‐hospital respiratory viral infections for patients with established BPD in the SARS‐CoV‐2 era

Kielt

Murphy

Smathers

et al. 2021

Pediatric Pulmonology

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Objective: Our objective was to test the hypothesis that in-hospital respiratory viral infections (RVI) would be significantly lower in a cohort of patients with established bronchopulmonary dysplasia (BPD) exposed to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection prevention protocol when compared to historical controls. Study Design: On April 1, 2020, we implemented a universal infection prevention protocol to minimize the risk of nosocomial SARS-CoV-2 transmission in a dedicated BPD intensive care unit. We performed a retrospective cohort study and included patients with established BPD, as defined by the 2019 Neonatal Research Network criteria, admitted to our center who underwent real-time polymerase-chain-reaction RVI testing between January 1, 2015 and March 31, 2021. We excluded patients readmitted from home. We compared the proportion of positive tests to the number of tests performed and the distribution of viral respiratory pathogens in the pre-and post-SARS-CoV-2 eras. Results: Among 176 patients included in the study, 663 RVI tests were performed and 172 (26%) tests were positive. The median number of tests performed, measured in tests per patient per month, in the SARS-CoV-2 era was not significantly different compared to the pre-SARS-CoV-2 era (0.45 vs. 0.34 tests per patient per month, p = .07). The proportion of positive RVI tests was significantly lower in the SARS-CoV-2 era when compared to the pre-SARS-CoV-2 era (0.06 vs. 0.30, p < .0001). No patients tested positive for SARS-CoV-2 in the SARS-CoV-2 era. Conclusions: Infection prevention measures developed in response to the SARS-CoV-2 pandemic may reduce the risk of RVIs in hospitalized patients with established BPD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In‐hospital respiratory viral infections for patients with established BPD in the SARS‐CoV‐2 era

Kielt

Murphy

Smathers

et al. 2021

Pediatric Pulmonology

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“…61 HMPV may therefore have more severe short- and long-term consequences in preterm infants than term infants, without the current recognition or treatment options available for RSV. 58 An investigation of possible reasons for the differential effects of HMPV on the context of prematurity may provide insight into mechanisms and future therapeutic strategies.…”

Section: Hmpv In Preterm Infantsmentioning

confidence: 99%

Human metapneumovirus in the preterm neonate: current perspectives

Maitre

Williams

2016

RRN

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Premature birth (<37 weeks gestation) occurs in ~11% of all births in the US. These infants are at risk of chronic lung disease and respiratory conditions, including bronchopulmonary dysplasia. Respiratory viruses are important causes of acute respiratory illness (ARI) in preterm infants, leading to rehospitalization, increased health care burden, and long-term morbidity. Human metapneumovirus (HMPV) is a paramyxovirus discovered in 2001 that is related to respiratory syncytial virus. Epidemiologic studies show that HMPV is a leading cause of ARI in children and adults worldwide. Prematurity is a major risk factor for severe HMPV disease, requiring hospitalization. Moreover, limited data suggest that HMPV infection during infancy is associated with asthma and recurrent wheezing, which are common long-term pulmonary complication of prematurity. HMPV causes nosocomial outbreaks of ARI in hospitals and long-term care facilities, although there are few studies of the prevalence of HMPV in neonatal intensive care unit populations. HMPV is a common and important virus in premature infants, and caregivers for preterm infants should consider this virus in patients with acute respiratory symptoms.

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“…7,20 We hypothesize that identification of clinical events in the patient's NICU course and shortly afterward can predict risk for early rehospitalization and increased pulmonary morbidity over time. 8,11 Identifying these risk factors will allow for development of more precise management protocols, necessary for continued cost-effective management of this rapidly growing patient population.…”

mentioning

confidence: 99%

Rehospitalization in Infants Born < 29 Weeks' Gestation during the First 2 Years of Life: Risk Assessment

Taylor

Nyp

et al. 2015

Amer J Perinatol

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Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia

Abstract: Viral infections caused more long-term pulmonary morbidity/mortality than bacterial infections on premature lung health, even when controlling for BPD.

Cited by 6 publications

References 33 publications

In‐hospital respiratory viral infections for patients with established BPD in the SARS‐CoV‐2 era

In‐hospital respiratory viral infections for patients with established BPD in the SARS‐CoV‐2 era

Human metapneumovirus in the preterm neonate: current perspectives

Rehospitalization in Infants Born < 29 Weeks' Gestation during the First 2 Years of Life: Risk Assessment

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