Multi-model ensembles can be used to estimate uncertainty in projections of regional climate, but this uncertainty often depends on the constituents of the ensemble. The dependence of uncertainty on ensemble composition is clear when single model initial condition large ensembles (SMILEs) are included within a multi-model ensemble. SMILEs introduce "new" information into a multi-model ensemble by representing region-scale internal variability, but also introduce redundant information, by virtue of a single model being represented by 50-100 outcomes. To preserve the contribution of internal 5 variability and ensure redundancy does not overwhelm uncertainty estimates, a weighting approach is used to incorporate 50members of the Community Earth System Model (CESM1.2.2), 50-members of the Canadian Earth System Model (CanESM2), and 100-members of the MPI Grand Ensemble (MPI-GE) into an 88-member Coupled Model Intercomparison Project Phase 5 (CMIP5) multi-model ensemble. The weight assigned to each multi-model ensemble member is based on the member's ability to reproduce observed climate (performance) and scaled by a measure of redundancy (dependence). Surface air temperature 10 (SAT) and sea level pressure (SLP) diagnostics are used to determine the weights, and relationships between present and future diagnostic behavior are discussed. A new diagnostic, estimated forced trend, is proposed to replace a diagnostic with no clear emergent relationship, 50-year regional SAT trend.The influence of the weighting is assessed in estimates of Northern European winter and Mediterranean summer end-ofcentury warming in the CMIP5 and combined SMILE-CMIP5 multi-model ensembles. The weighting is shown to recover 15 uncertainty obscured by SMILE redundancy, notably in Mediterranean summer. For each SMILE, the independence weight of each ensemble member as a function of the number of SMILE members included in the CMIP5 ensemble is assessed. The independence weight increases linearly with added members with a slope that depends on SMILE, region, and season. Finally, it is shown that the weighting method can be used to guide SMILE member selection if a subsetted ensemble with one member per model is sought. The weight a SMILE receives within a subsetted ensemble depends on which member is used to represent 20 it, reinforcing the advantage of weighting and incorporating all initial condition ensemble members in multi-model ensembles. Projections of regional climate change are both key to climate adaptation policy and fundamentally uncertain due to the nature of the climate system (Deser et al., 2012;Kunreuther et al., 2013). In order to represent regional climate uncertainty to policy-25 makers, scientists often turn to multi-model ensembles to provide a range of plausible outcomes a region may experience (Tebaldi and Knutti, 2007). Uncertainty in a multi-model ensemble is commonly estimated from the ensemble spread, which can be represented e.g., as the 5-95% likely range of the distribution and is usually presented with respect to the ...