Impact of interventional edge-to-edge repair on mitral valve geometry

Schueler, Robert; Kaplan, Sarah; Melzer, Charlotte; Öztürk, Can; Weber, Marcel; Sinning, Jan‐Malte; Welz, Armin; Werner, Nikos; Nickenig, Georg; Hammerstingl, Christoph

doi:10.1016/j.ijcard.2016.12.081

Cited by 22 publications

(25 citation statements)

References 30 publications

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“…Thus far, several 3D TEE studies have suggested geometrical effect with regard to MV annulus diameter during MitraClip implantation in patients with FMR. These studies discovered reduction in AP diameter in FMR 4,5,18 and demonstrated its association with MR improvement 3,4 …”

Section: Discussionmentioning

confidence: 90%

“…Linear regression analysis revealed that prolapse volume and height 4,5,18 and demonstrated its association with MR improvement. 3,4 In this study, we were able to demonstrated that, transapical edge-to-edge repair…”

Section: Discussionmentioning

confidence: 93%

“…The AP diameter reduction by MitraClip in degenerative MR remained controversial 3,5,18,19 . A more recent study by Patzelt et al indicated reduction in MV annulus AP diameters in a larger cohort of 77 patients with DMR and showed its correlation with residual MR.…”

Section: Discussionmentioning

confidence: 99%

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Effect of a novel transcatheter edge‐to‐edge repair device on the three‐dimensional geometry of mitral valve in degenerative mitral regurgitation

Pan

Zhou

et al. 2020

Cathet Cardio Intervent

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Objectives: We sought to assess the acute intraprocedural effects of the ValveClamp system in DMR patients on the mitral valve (MV) three-dimensional (3D) geometry and the association of these effects with mitral regurgitation (MR) reduction. Background: Few data are available about the specific impact of transcatheter edgeto-edge repair in patients with degenerative mitral regurgitation (DMR). Methods: Thirty-five symptomatic patients (age 74.26 ± 6.61 years) with Grade 3 to 4+ degenerative MR underwent 3D transoesophageal echocardiography (TEE) during ValveClamp implantation. Volumetric data sets were retrospectively analyzed using mitral valve quantitative 3D modeling software. Results: Mitral valve annular anterior-posterior (AP) diameter decreased from 33.24 ± 4.03 to 31.12 ± 3.66 mm (p < .001), and prolapse height from 4.78 ± 2.19 to 2.32 ± 1.92 mm (p < .001), and total exposed leaflet area from 1,110.29 ± 224.21 mm 2 to 1,013.44 ± 228.71 mm (p = .004). Accordingly, we observed a significant reduction of MR severity after ValveClamp implantation. Multivariable analysis revealed postprocedural MR reduction was associated with shortening in anterior-posterior diameter (coefficient 0.427, p = .008) and reduction in prolapse height (coefficient 0.369, p = .021). Conclusions: ValveClamp implantation exerts an acute effect on the 3D MV geometry. Postprocedural reduction in AP diameter and reduction in prolapse height correlates with MR downgrading in patients with degenerative MR.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 93%

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Effect of a novel transcatheter edge‐to‐edge repair device on the three‐dimensional geometry of mitral valve in degenerative mitral regurgitation

Pan

Zhou

et al. 2020

Cathet Cardio Intervent

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“…First, to identify the source of heterogeneity among the studies investigating the number of patients with implanted MC ≥2, a subgroup analysis was conducted based on the proportion of DMR patients and the subject number ( Figure 6). The studies by Schueler et al and Grasso et al (15,21), which the subject number is small and the proportion of DMR patients is less than 30%, were pooled into subgroup 1. Subgroup 1 showed that the number of DMR patients with implanted MC ≥2 was more than twice that of the FMR patients with a mild heterogeneity (RR =2.20; 95% CI: 1.60 to 3.02; P<0.001; I 2 =8.9%).…”

Section: Heterogeneity Among Studiesmentioning

confidence: 99%

Short-term and 1-year outcomes after MitraClip therapy in functional versus degenerative mitral regurgitation patients: a systematic review and meta-analysis

et al. 2018

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“…RT3D TEE has also shown to play an important role with MitraClip implantation [ 73 ]. Comparing RT3D TEE and 2D TEE in percutaneous mitral valve repair, 3D imaging is more effective in optimizing the trans-septal puncture site, guiding and positioning the clip delivery system, positioning the regurgitant jet, visualizing the clip with respect to the valve orifice, and evaluating the residual regurgitant jet(s) [ 74 ].…”

Section: Applications Of 3dementioning

confidence: 99%

3D and 4D Ultrasound: Current Progress and Future Perspectives

Gopal

2017

Curr Cardiovasc Imaging Rep

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Purpose of ReviewThree-dimensional (3D) echocardiography (3DE) and 4-dimensional echocardiography (4DE), also known as real-time (RT) 3DE (RT3DE), are rapidly emerging technologies which have made significant impact in the clinical arena over the years. This review will discuss the recent applications of 3DE in diagnosing and treating different types of cardiovascular disease.Recent FindingsRecent studies using 3DE expanded on prior findings and introduced additional applications to different cardiac conditions. Some studies have used 3D parameters to prognosticate long-term outcomes. Numerous innovative software designs including fully automated algorithms have been introduced to better evaluate valvular heart disease and cardiac function.SummaryWith further evolution of 3DE technologies, this imaging modality will emerge as a powerful tool and likely become the imaging modality of choice in the diagnosis and management of various cardiac disorders.

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Impact of interventional edge-to-edge repair on mitral valve geometry

Cited by 22 publications

References 30 publications

Effect of a novel transcatheter edge‐to‐edge repair device on the three‐dimensional geometry of mitral valve in degenerative mitral regurgitation

Effect of a novel transcatheter edge‐to‐edge repair device on the three‐dimensional geometry of mitral valve in degenerative mitral regurgitation

Short-term and 1-year outcomes after MitraClip therapy in functional versus degenerative mitral regurgitation patients: a systematic review and meta-analysis

3D and 4D Ultrasound: Current Progress and Future Perspectives

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