Impact of Intravenous Magnesium on Post-Cardiothoracic Surgery Atrial Fibrillation and Length of Hospital Stay: A Meta-Analysis

Henyan, Nickole N.; Gillespie, Effie L.; White, C Michael; Kluger, Jeffrey; Coleman, Craig I.

doi:10.1016/j.athoracsur.2005.03.036

Cited by 47 publications

(34 citation statements)

References 18 publications

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“…The results of several clinical studies suggest that magnesium has inherent antiarrhythmic properties, such as delaying atrial impulse conduction and prolonging effective refractory periods, which can improve conversion of atrial arrhythmias [9][10][11]. Magnesium monotherapy has been shown to be more effective in converting atrial fibrillation or flutter than was verapamil or diltiatzem, agents with no intrinsic antiarrhythmic properties in these arrhythmias [12,13].…”

Section: Pre-injection Of Magnesium and Conversion Ratesmentioning

confidence: 97%

Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter

Steinwender

Hönig

Kypta

et al. 2010

International Journal of Cardiology

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Section: Pre-injection Of Magnesium and Conversion Ratesmentioning

confidence: 97%

Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter

Steinwender

Hönig

Kypta

et al. 2010

International Journal of Cardiology

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“…A recent trial has shown the benefit of magnesium orotate in cardiac failure [11]. Magnesium has been clearly shown to reduce arrhythmias after coronary bypass surgery [22]. …”

Section: Metabolic Regimenmentioning

confidence: 99%

Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial

Leong

Merwe

Pepe

et al. 2010

Heart, Lung and Circulation

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“…However, the clinical utility of magnesium in preventing cardiac arrhythmias is controversial. Two meta-analyses found that prophylactic magnesium administration decreased the incidence of postcardiothoracic surgery atrial fibrillation [22,23], although the dose of administered magnesium varied widely among trials.…”

Section: Magnesium and Cardiovascular Healthmentioning

confidence: 99%

Magnesium in Chronic Kidney Disease: Unanswered Questions

Spiegel

2011

Blood Purif

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Background: Magnesium ion is critical for life and is integrally involved in cellular function and a key component of normal bone mineral. In health, the kidneys, gastrointestinal tract and bone are responsible for maintaining serum magnesium concentrations in the normal range and magnesium balance. Most clinical disorders involving magnesium, other than chronic kidney disease (CKD), result in hypomagnesemia, either from gastrointestinal or kidney losses. CKD and particularly end-stage kidney disease is the only clinical condition where sustained hypermagnesemia may occur and net magnesium balance may be positive. Methods: This review will focus on normal magnesium homeostasis and review the literature in CKD with a particular focus on end-stage kidney disease and the potential role of magnesium as a phosphate binder and in cardiovascular and bone health. Results: A number of small to medium-size interventional trials have shown that magnesium-based compounds can serve as effective phosphate binders. Observational studies suggest that higher serum magnesium concentrations in dialysis patients may improve survival and may slow the progression of vascular calcification. While a few small prospective trials support these findings, no large or long-term studies are available. Conclusions: Magnesium balance remains poorly understood in patients with end-stage kidney disease. While observational and small randomized trials suggest that exogenous administration may be useful as a phosphate binder and may have protective cardiovascular effects in terms of both arrhythmias and vascular calcification, large randomized trials are needed to test these hypotheses.

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Impact of Intravenous Magnesium on Post-Cardiothoracic Surgery Atrial Fibrillation and Length of Hospital Stay: A Meta-Analysis

Cited by 47 publications

References 18 publications

Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter

Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter

Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial

Magnesium in Chronic Kidney Disease: Unanswered Questions

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