Impact of lactoferrin supplementation on oxidative stress, gene expression and immunity dysfunction induced by 
            <i>Aeromonas veronii</i>
            in Nile tilapia (
            <i>Oreochromis niloticus</i>
            )

Hashem, Nada Mohamed Ali; El‐Son, Mai A. M.; Ateya, Ahmed; Saleh, Rasha M.

doi:10.1111/are.15757

Cited by 9 publications

(5 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ndings suggest dietary LF intervention could promote the intestinal antioxidant capacity and prevent the intestinal lipid peroxidation in juvenile orange-spotted groupers with SBMIE, through in uencing both enzymatic and non-enzymatic antioxidants. Consistent with our results, a reduction of liver MDA content on day 15 and an increase in liver T-AOC on day 30 were observed after Aeromonas veronii-induced Nile tilapias were administrated with LF at 0.8 g/kg diet [95]; Increased SOD activity and decreased MDA content in the hepatopancreas were observed in shrimp receiving the diets with 1.5-2.5 g/kg LF [96]; Similar effects occurred for weaned piglets when they were fed diets with LF [36]. The above results validated that dietary LF intervention has a protective effect against oxidative stress resulting from different sources of stress.…”

Section: Discussionsupporting

confidence: 91%

Dietary lactoferrin supplementation improves growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides)

Song

Qin

et al. 2022

Preprint

View full text Add to dashboard Cite

A 56-day feeding trial was conducted to investigate the effects of dietary lactoferrin (LF) supplementation on growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides) fed high soybean meal (SBM) diets. The control diet (FM) and high soybean meal diet (SBM60) were prepared to contain 48% protein and 11% fat. Three inclusion levels of 2, 6, and 10 g/kg LF were added into the SBM diets to prepare three experimental diets (recorded as LF2, LF6, and LF10, respectively). The results showed that supplementation of LF in SBM diets increased growth rate in a dose dependent manner. However, feed utilization, hepatosomatic index, whole-body proximate composition and the abundance and diversity of intestinal microbiota did not vary across dietary treatments (P > 0.05). After dietary intervention with LF, the contents of intestinal malondialdehyde, endotoxin, and D-lactic acid, as well as plasma low density lipoprotein cholesterol, high density lipoprotein cholesterol and total cholesterol were lower, and the intestinal activities of glutathione peroxidase, lipase, trypsin, and protease were higher in LF2-LF10 groups than that in SBM60 group (P < 0.05). Supplementation of LF in SBM diets increased the muscle layer thickness of middle and distal intestine and the mucosal fold length of middle intestine vs SBM60 diet. Furthermore, supplementation of LF in SBM diets resulted in an up-regulation of the mRNA levels for IL-10 and TGF-β1 genes and a down-regulation of the mRNA levels of IL-1β, IL-12, IL-8, and TNF-α genes vs SBM60 diet (P < 0.05). The above results showed that dietary LF intervention could improve the growth and alleviate soybean meal induced enteritis in juvenile orange-spotted groupers. The dietary appropriate level of LF was at 5.8 g/kg, through the regression analysis of percent weight gain against dietary LF inclusion levels.

show abstract

Section: Discussionsupporting

confidence: 91%

Dietary lactoferrin supplementation improves growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides)

Song

Qin

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The findings suggest a dietary LF intervention could promote the intestinal antioxidant capacity and prevent the intestinal lipid peroxidation in juvenile orange-spotted groupers with SBMIE, through influencing both enzymatic and non-enzymatic antioxidants. Consistent with our results, a reduction in the liver MDA content on day 15 and an increase in the liver T-AOC on day 30 were observed after Aeromonas veronii -induced Nile tilapias were administrated with LF at 0.8 g/kg diet [ 96 ]; increased SOD activity and decreased MDA content in the hepatopancreas were observed in shrimp receiving the diets with 1.5–2.5 g/kg LF [ 97 ]; and similar effects occurred for weaned piglets when they were fed diets with LF [ 37 ]. The above results validated that a dietary LF intervention has a protective effect against oxidative stress resulting from different sources of stress.…”

Section: Discussionsupporting

confidence: 87%

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Song

Qin

et al. 2022

Metabolites

View full text Add to dashboard Cite

A 56-day feeding trial was conducted to investigate the effects of dietary lactoferrin (LF) supplementation on the growth performance and intestinal health of juvenile orange-spotted groupers fed high-soybean-meal (SBM) diets. The control diet (FM) and high-soybean-meal diet (SBM60) were prepared to contain 480 g/kg protein and 110 g/kg fat. Three inclusion levels of 2, 6, and 10 g/kg LF were added into the SBM60 to prepare three diets (recorded as LF2, LF6, and LF10, respectively). The results showed that the supplementation of LF in SBM60 increased the growth rate in a dose-dependent manner. However, the feed utilization, hepatosomatic index, whole-body proximate composition, and the abundance and diversity of intestinal microbiota did not vary across the dietary treatments (p > 0.05). After the dietary intervention with LF, the contents of the intestinal malondialdehyde, endotoxin, and d-lactic acid, as well as the plasma low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and total cholesterol were lower, and the intestinal activities of the glutathione peroxidase, lipase, trypsin, and protease were higher in the LF2-LF10 groups than that in the SBM60 group (p < 0.05). The supplementation of LF in SBM60 increased the muscle layer thickness of the middle and distal intestine and the mucosal fold length of the middle intestine vs. the SBM60 diet (p < 0.05). Furthermore, the supplementation of LF in SBM60 resulted in an up-regulation of the mRNA levels for the IL-10 and TGF-β1 genes and a down-regulation of the mRNA levels of the IL-1β, IL-12, IL-8, and TNF-α genes vs. the SBM60 diet (p < 0.05). The above results showed that a dietary LF intervention improves the growth and alleviates soybean meal-induced enteritis in juvenile orange-spotted groupers. The dietary appropriate level of LF was at 5.8 g/kg, through the regression analysis of the percent weight gain against the dietary LF inclusion levels.

show abstract

“…Shao et al reported that supplementation of 100 mg/kg/day of LfcinB in the diet of lactating dairy goats could reduce oxidative stress and inhibit mammary gland inflammation ( 70 ). Hashem et al found that Lf could improve the immune characteristics and antioxidant status of Oreochromis niloticus when added to the diet, showing a better improvement than hyoscine ( 71 ). On the whole, it can be seen that Lf is a dietary supplement with excellent properties, playing positive effects on immune regulation, disease resistance and antioxidant in animals.…”

Section: Physicochemical Properties and Applications Of Lactoferrinmentioning

confidence: 99%

Lactoferrin: A glycoprotein that plays an active role in human health

Cao

Ren

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts. Moreover, it is non-toxic and has good compatibility with other supplements. Thus, Lf has been widely used in food nutrition, drug carriers, biotechnology, and feed development. Although Lf has been continuously explored and studied, a more comprehensive and systematic compendium is still required. This review presents the recent advances in the structure and physicochemical properties of Lf as well as clinical studies on human diseases, with the aim of providing a reference for further research of Lf and the development of its related functional products.

show abstract

Impact of lactoferrin supplementation on oxidative stress, gene expression and immunity dysfunction induced by Aeromonas veronii in Nile tilapia ( Oreochromis niloticus )

Cited by 9 publications

References 95 publications

Dietary lactoferrin supplementation improves growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides)

Dietary lactoferrin supplementation improves growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides)

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Lactoferrin: A glycoprotein that plays an active role in human health

Contact Info

Product

Resources

About