Impact of left ventricular longitudinal diastolic functional reserve on clinical outcome in patients with type 2 diabetes mellitus

Abstract

Assessment of left ventricular longitudinal DFR during exercise provided incremental prognostic information in patients with type 2 DM without overt heart disease.

The Impact of Diabetes Mellitus on Vascular Biomarkers in Patients with End-Stage Renal Disease

“…It is well known that DM patients have blunted LV long-axis performances at rest19 and during exercise 20. As previously reported, diastolic dysfunction is more advanced in patients with DM192021 and ESRD;22 however, our data failed to show any difference in LV relaxation properties between the two groups. In addition, LAVI, reflecting chronicity and severity of diastolic function, was not different between the two groups.…”

“…E’ reflects early diastolic LV longitudinal relaxation, which is more vulnerable and is an earlier manifestation of cardiac dysfunction than LV radial motion, which is commonly expressed by LV EF in various diseases affecting the heart 18. It is well known that DM patients have blunted LV long-axis performances at rest19 and during exercise 20. As previously reported, diastolic dysfunction is more advanced in patients with DM192021 and ESRD;22 however, our data failed to show any difference in LV relaxation properties between the two groups.…”

Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart

“…In fact, diabetes is a major risk factor of HF with preserved ejection fraction (HFpEF), and HFpEF often decompensates when blood pressure is elevated [3]. Latent diastolic dysfunction detectable by an exercise stress test in patients with T2DM has been shown to predict high cardiovascular mortality [4]. In patients with HFpEF, increased systolic pressure by exercise induces an upward shift of the diastolic LV pressure-volume relationship (PVR) and elevation of LV end-diastolic pressure (LVEDP), suggesting that LV diastolic reserve against acute loading is impaired [5,6].…”

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

“…78 Higher left ventricular mass in people with diabetes mellitus predicts decline in kidney 79,80 and cardiac 81,82 function and was an independent predictor of hard cardiovascular events in adults with T2DM. 83 Similarly, Nadeau et al 84 found higher body size-indexed left ventricular mass in adolescents with T1DM compared with control subjects. Abnormal ambulatory BP patterns were also associated with higher left ventricular mass in youth with T1DM.…”