Impact of Liver Injury in COVID-19 Patients: Single-center Retrospective Cohort Analysis

Desai, Jiten; Patel, Upenkumar; Arjun, Shiva; Farraj, Kristen; Yeroushalmi, Kevin; Paz, Sandra Gomez; Im, Jaehyuck; Castillo, Andres; Rammohan, Rajmohan; Mustacchia, Paul

doi:10.14218/jcth.2020.00075

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…All published literature which analyzed liver biochemical parameters in COVID-19 patients was examined through databases and shown in Table 1 [ 5 , 6 , 11 , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] ]. Based on previous studies, liver biochemical parameters abnormalities were defined as the elevation of the following liver enzymes in serum: ALT > 40 U / L, AST > 40 U / L, and total bilirubin> 1.20 mg/d l. As in a previous study, we defined ALT and/or AST over three times upper limits of normal (ULN), and/or total bilirubin over two times ULN as liver injury [7] .…”

Section: Methodsmentioning

confidence: 99%

Liver function as a predictor of mortality in COVID-19: A retrospective study

Salık

Uzundere

Bıçak

et al. 2021

Annals of Hepatology

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Introduction and Objectives In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. Materials and Methods In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. Results 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. Conclusions The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.

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Section: Methodsmentioning

confidence: 99%

Liver function as a predictor of mortality in COVID-19: A retrospective study

Salık

Uzundere

Bıçak

et al. 2021

Annals of Hepatology

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“…At the initial examination, 6462 studies were obtained, which were screened and evaluated layer by layer according to inclusion and exclusion criteria, and 49 studies were finally included, most of which were retrospective studies, from 10 countries, with a total of 23,611 COVID-19 patients, including 9357 cases complicated with liver injury. [7–55] The flow chart of literature screening is shown in Figure 1. The basic characteristics of the included literature are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Shen 2021 [11] Retrospective China/Hubei >1 ULN 356 52.11 (17.9) 177 ac ①②③④⑤⑥ 6. Desai 2020 [12] Retrospective America >1 ULN 639 58.89 (15.61) 476 b ①② 7. Shousha 2021 [13] Cohort study Egypt >1 ULN 428 45.04(17.61) 137 b ②⑦ 8.…”

Section: Incidence Of Liver Injury In Patients With Covid-19mentioning

confidence: 99%

Meta-analysis of liver injury in patients with COVID-19

Fan

Jin

et al. 2023

Medicine

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Background: The coronavirus disease 2019 (COVID-19) is a major public health problem threatening human health. It can lead to multiple system complications, among which liver damage is also a common complication of COVID-19. The pathogenesis of liver injury is complex and involves the interaction of multiple factors. This study aims to investigate the incidence and risk factors of liver injury in COVID-19 patients and analyze the impact of liver injury on clinical prognosis of patients, so as to provide corresponding basis for clinical diagnosis and treatment. Methods: PubMed and Cochrane Library were searched in computer to collect original studies on liver injury cases, laboratory indicators and clinical outcomes in COVID-19 patients. Articles were screened according to inclusion and exclusion criteria, and data were meta-analyzed using Stata12.0 software. Results: A total of 49 studies, including 23,611 patients with COVID-19, had a prevalence of liver injury of 39.63%. Subgroup analysis found that patients in the Americas had the highest incidence of liver injury at 43.7% and lowest in Africa (25.99%). The vast majority of liver injury is manifested by aminotransferase or bilirubin levels greater than 1 times the upper limit of normal (49.16%). The older the age, the male, the associated chronic liver disease, and the higher the levels of white blood cells, neutrophils, and C-reactive protein, the higher the risk of liver injury. The use of hormones, hydroxychloroquine, and tocilizumab increases the risk of liver injury. Patients with concurrent liver injury have longer hospital stays, are more likely to progress to severe cases, and have a higher risk of death than patients without liver injury. Conclusion: The incidence of liver injury in COVID-19 patients was high, affected by age, gender, chronic liver disease, inflammatory state and medication, and patients with liver injury were hospitalized longer and were more likely to have a poor prognosis. Therefore, clinical attention should be paid to early intervention.

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“…34 In addition, this dog had evidence of liver injury, which is commonly reported in human COVID-19, and can occasionally be severe. 5,35 The mechanism of liver injury remains unclear, but may be due direct infection of liver cells with SARS-CoV-2 and systemic inflammation. 36 Consistent with previously reported data in humans 37 in whom SARS-CoV-2 RNA levels peak in the nasopharynx 2-6 days after the onset of symptoms, [38][39][40] the dog tested negative for SARS-CoV-2 on the first day of sampling of saliva and feces.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Manifestation of Severe SARS-CoV-2 Infection in an Immunocompromised Dog

Lennon¹,

Oceguera²,

Braun³

et al. 2021

Preprint

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SARS-CoV-2 infects a range of host species. However, the susceptibility of companion animals to SARS-CoV-2 and their potential ability to transmit the virus to humans remains unclear. Here, we present a detailed clinical description of an immunosuppressed dog that was infected with SARS-CoV-2. The dog had severe gastrointestinal (GI) clinical signs, coagulopathy, elevated hepatic transaminases, and met canine systemic inflammatory response syndrome criteria, without respiratory clinical signs, mirroring a subset of humans with GI-restricted COVID-19. Viral sequencing demonstrated divergence from other reported sequences, based on phylogenetic analysis. The dog shed high levels of virus for a prolonged time period with positive virus isolation. The dog’s immunosuppressed state may have increased both susceptibility to infection and disease progression. Together, our findings suggest that certain individual companion animals may be at higher risk for severe SARS-CoV-2 infection, COVID-19-like disease, and high viral shedding, which may pose a transmission risk to humans.

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Impact of Liver Injury in COVID-19 Patients: Single-center Retrospective Cohort Analysis

Cited by 6 publications

References 6 publications

Liver function as a predictor of mortality in COVID-19: A retrospective study

Liver function as a predictor of mortality in COVID-19: A retrospective study

Meta-analysis of liver injury in patients with COVID-19

Gastrointestinal Manifestation of Severe SARS-CoV-2 Infection in an Immunocompromised Dog

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