Impact of Long-Rope Jumping on Monoamine and Attention in Young Adults

Yamashita, Masatoshi; Yamamoto, Takanobu

doi:10.3390/brainsci11101347

Cited by 5 publications

(7 citation statements)

References 63 publications

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“…The current results represent a starting point, and further research is expected to determine how HA during running correlates with positive mood changes. It would be interesting to investigate the effects of dose-response for head acceleration and other forms of rhythmic up-and-down oscillations such as jump rope (Yamashita & Yamamoto, 2021).…”

Section: Discussionmentioning

confidence: 99%

Slow running benefits: Boosts in mood and facilitation of prefrontal cognition even at very light intensity

Damrongthai,

Kuwamizu,

Yamazaki

et al. 2024

Preprint

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Although running upright has been reported to have positive effects on both physical and mental health, the minimum running intensity/speed that would benefit mood and prefrontal cognition is not yet clear. For this reason, we aimed to investigate the acute effect of very slow running, which is classified as a very light intensity exercise, on mood, executive function (EF), and their neural substrates in the prefrontal cortex (PFC). Twenty-four healthy participants completed a 10-minute very slow running session on a treadmill at 35%and a resting control session in randomized order. EF was measured using the Stroop task and the mood state was measured using the Two-Dimensional Mood Scale (TDMS) before and after both sessions. Cortical hemodynamic changes while performing the task were monitored using functional near-infrared spectroscopy (fNIRS). The results show that ten minutes of very slow running significantly enhanced mood, reduced Stroop interference time (i.e., enhanced EF), and elicited left lateral PFC activation. Moreover, head acceleration, the magnitude of up-and-down oscillations, was measured during running, and a significant positive correlation with pleasant mood was found. Head acceleration is a remarkable characteristic of running and may be one of the factors related to a pleasant mood induced by very slow running. In conclusion, the current study reveals that a single bout of running, even at very slow speed, elicits a pleasant mood and improved executive function with enhancing activation in prefrontal subregions. This shed light on the slow running benefits to brain health.

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Section: Discussionmentioning

confidence: 99%

Slow running benefits: Boosts in mood and facilitation of prefrontal cognition even at very light intensity

Damrongthai,

Kuwamizu,

Yamazaki

et al. 2024

Preprint

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“…Urinary levels of monoamine metabolites and tryptophan, which have been proposed as predictive, cost-effective and non-invasive biomarkers of brain function,52 56 70–72 will be measured in children with ADHD, ASD and typical development. Prior to testing, the participants will be instructed to refrain from intense physical activity and the intake of food and beverages, such as alcohol, coffee, high-fat fish, red beef and blue cheese, which can be difficult to digest, for 24 hours.…”

Section: Methods and Analysismentioning

confidence: 99%

“…On the test day, fresh urine will be collected after participants are made to rest for 30 min. Freshly collected urine samples will be diluted with 6.7 mM hydrochloric acid and 2.5% perchloric acid to separate albumin, as previously reported 72. The obtained supernatant will be stored at −78°C until high-performance liquid chromatography (Nanospace SI-2 3001; Shiseido Japan Co, Tokyo, Japan) assay with an electrochemical detector (Nanospace SI-2 3005; Shiseido Japan Co) and a chromate recorder (C-R8A; Shimadzu Corporation, Kyoto, Japan).…”

Section: Methods and Analysismentioning

confidence: 99%

Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

et al. 2023

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IntroductionNeuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.Methods and analysisWe will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.Ethics and disseminationThe study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

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“…But most importantly, the development of central fatigue is most likely amplified and triggered by the synergistic action of tryptophan and its metabolite, kynurenic acid In addition to the prefrontal glutamatergic neurons in Fig. 2, attention-related locus coeruleus-prefrontal noradrenergic neurons can be envisioned [ 41 , 42 ] F-TRP: free tryptophan, TRP: tryptophan, KYNA: kynurenic acid, KYN: kynurenine, 5-HT: serotonin (5-hydroxytryptamine), Alb: albumin, FFA: free fatty acid, CA: catecholamine, 5-HIAA: 5-hydroxyindoleacetic acid, 5-HTP: 5-hydroxytryptophan, LAT1: L-amino acid transporter, NMDA-R: n-methyl-d-aspartate-R, α7-nACh-R: α7-nicotinic acetylcholine-R, Ah-R: aryl hydrocarbon-R, GPR139: orphan GPR139 receptor, BCAAs: branched-chain amino acids …”

Section: Tryptophan-kynurenic Acid Synergy Hypothesis Of Central Fatiguementioning

confidence: 99%

“… In addition to the prefrontal glutamatergic neurons in Fig. 2, attention-related locus coeruleus-prefrontal noradrenergic neurons can be envisioned [ 41 , 42 ] …”

Section: Tryptophan-kynurenic Acid Synergy Hypothesis Of Central Fatiguementioning

confidence: 99%

The relationship between central fatigue and Attention Deficit/Hyperactivity Disorder of the inattentive type

Yamamoto

2022

Neurochem Res

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Chronic fatigue and central fatigue with malaise significantly impair quality of life. Inattention caused by central fatigue is closely related to attention deficit/hyperactivity disorder (ADHD) symptoms, but the neurochemical mechanism of central fatigue remains hypothetical. The serotonin hypothesis of central fatigue was proposed first, serving as the central dogma for the molecular and neural mechanisms of central fatigue, and underpinning many studies. The tryptophan hypothesis was proposed because tryptophan released into the synaptic cleft of neurons in the brain coincides with and responds sensitively to development of fatigue. Tryptophan is highly bioactive, with brain concentrations of 50 to 200 times that of serotonin. The tryptophan-kynurenic acid-synergy hypothesis posits that central fatigue is not monocausal but a synergistic effect between tryptophan itself and its catabolite kynurenic acid. Central fatigue is associated with mental health problems and is a cause of inattention, thereby warranting scrutiny for its relationship with ADHD. Fatigability in ADHD is mediated by tryptophan, in which abnormal enhancement of the tryptophan-kynurenine-kynurenic acid pathway causes an imbalance in monoamine nervous system function. Notably, noradrenergic neuronal dysfunction is associated with the characteristic inattention of ADHD. Neutral amino acids such as branched-chain amino acids (BCAAs) can assist recovery from attentional and cognitive decline caused by central fatigue. Since they are transported by the same L-amino acid transporter as tryptophan, BCAAs compete with tryptophan to inhibit its brain uptake. Controlling central fatigue this way may improve attentional cognitive performance.

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Impact of Long-Rope Jumping on Monoamine and Attention in Young Adults

Cited by 5 publications

References 63 publications

Slow running benefits: Boosts in mood and facilitation of prefrontal cognition even at very light intensity

Slow running benefits: Boosts in mood and facilitation of prefrontal cognition even at very light intensity

Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

The relationship between central fatigue and Attention Deficit/Hyperactivity Disorder of the inattentive type

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