Abstract:In recent decades, magnetite nanoparticles received greater attention in nanobiotechnology due to wide applications. This study presents the influence of the oxidative stress caused by magnetite nanoparticles coated with aspartic acid (A-MNP) of 9.17 nm mean diameter size, on maize (Zea mays) seedlings, in terms of growth, enzymatic activity and chlorophyll content as evaluated in exposed plant tissues. Diluted suspensions of colloidal magnetite nanoparticles stabilized in water were added to the culture mediu… Show more
“…Contrarily, the exposure of fish to MNG in the Pb-exposed group has an antioxidant-protecting effect indicated by a clear modulation in the antioxidant biomarkers (elevated SOD and CAT activities) resulting in protection from oxidative damage. In line with a recent finding, Răcuciu et al [ 45 ] confirmed that Fe 3 O 4 NPs have potent antioxidant enzymatic activity via modulating the levels of CAT and SOD and aid in plant development. Moreover, Fe 3 O 4 NPs can enhance the antioxidant status and reduce the oxidative stress of O. niloticus and Indian major carp ( Labeo rohita ) [ 14 , 46 , 47 ].…”
Heavy metal toxicity is an important issue owing to its harmful influence on fish. Hence, this study is a pioneer attempt to verify the in vitro and in vivo efficacy of a magnetite (Fe3O4) nanogel (MNG) in mitigating waterborne lead (Pb) toxicity in African catfish. Fish (n = 160) were assigned into four groups for 45 days. The first (control) and second (MNG) groups were exposed to 0 and 1.2 mg L−1 of MNG in water. The third (Pb) and fourth (MNG + Pb) groups were exposed to 0 and 1.2 mg L−1 of MNG in water and 69.30 mg L−1 of Pb. In vitro, the MNG caused a dramatic drop in the Pb level within 120 h. The Pb-exposed group showed the lowest survival (57.5%) among the groups, with substantial elevations in hepato-renal function and lipid peroxide (MDA). Moreover, Pb exposure caused a remarkable decline in the protein-immune parameters and hepatic antioxidants, along with higher Pb residual deposition in muscles and obvious histopathological changes in the liver and kidney. Interestingly, adding aqueous MNG to Pb-exposed fish relieved these alterations and increased survivability. Thus, MNG is a novel antitoxic agent against Pb toxicity to maintain the health of C. gariepinus.
“…Contrarily, the exposure of fish to MNG in the Pb-exposed group has an antioxidant-protecting effect indicated by a clear modulation in the antioxidant biomarkers (elevated SOD and CAT activities) resulting in protection from oxidative damage. In line with a recent finding, Răcuciu et al [ 45 ] confirmed that Fe 3 O 4 NPs have potent antioxidant enzymatic activity via modulating the levels of CAT and SOD and aid in plant development. Moreover, Fe 3 O 4 NPs can enhance the antioxidant status and reduce the oxidative stress of O. niloticus and Indian major carp ( Labeo rohita ) [ 14 , 46 , 47 ].…”
Heavy metal toxicity is an important issue owing to its harmful influence on fish. Hence, this study is a pioneer attempt to verify the in vitro and in vivo efficacy of a magnetite (Fe3O4) nanogel (MNG) in mitigating waterborne lead (Pb) toxicity in African catfish. Fish (n = 160) were assigned into four groups for 45 days. The first (control) and second (MNG) groups were exposed to 0 and 1.2 mg L−1 of MNG in water. The third (Pb) and fourth (MNG + Pb) groups were exposed to 0 and 1.2 mg L−1 of MNG in water and 69.30 mg L−1 of Pb. In vitro, the MNG caused a dramatic drop in the Pb level within 120 h. The Pb-exposed group showed the lowest survival (57.5%) among the groups, with substantial elevations in hepato-renal function and lipid peroxide (MDA). Moreover, Pb exposure caused a remarkable decline in the protein-immune parameters and hepatic antioxidants, along with higher Pb residual deposition in muscles and obvious histopathological changes in the liver and kidney. Interestingly, adding aqueous MNG to Pb-exposed fish relieved these alterations and increased survivability. Thus, MNG is a novel antitoxic agent against Pb toxicity to maintain the health of C. gariepinus.
“…Similarly, the positive control treated with vitamin C also significantly induced the antioxidant enzymes, catalyzing the conversion of superoxides (O 2 − ) to less reactive H 2 O 2 [ 7 ]. The loss of SOD activity is linked to membrane lipid peroxidation, protein carbonylation, and DNA breakage [ 8 ]. Lipid peroxidation (POD) is a well-known mechanism, used as an indicator of oxidative stress in cells.…”
Section: Resultsmentioning
confidence: 99%
“…Mangifera indica L. is a popular fruit whose extract has been reported to have several beneficial medicinal properties other than nutritional purposes [ 4 ]. Its peels and kernel extracts comprising 40–50% of its weight contain a high amount of bioactive compounds i.e., gallic acids, quercetin, mangiferin, catechin, epicatechin, quercetin, isoquercetin, fisetin, rutin, ellagic acid, gallic acid, gallates, condensed tannins, gallotannins, anthocyanin, and astragalin [ 5 , 6 , 7 , 8 , 9 ]. These compounds have good potency to control the overproduction of FRs [ 10 ].…”
Although Mangifera indica L. extract (M-Ext) of the peel and kernel possesses potent antioxidant and excellent antiaging qualities, the effects are only partially seen because of the skin’s limited ability to absorb it. M-Ext was loaded into nanolipid carriers (M-NLCs) in this work to create a green topical formulation that would boost antiaging efficacy and address penetration deficit. Compound identification was done using GCMS and atomic absorption spectroscopy for heavy metals in M-Ext. M-Ext was also evaluated against oxidative stress antioxidant enzymes. The M-NLCs were fabricated and evaluated for their physicochemical characterizations. Cytotoxicity and cell permeation analysis of M-Ext and M-NLCs were carried out in fibroblasts and HaCaT cell lines. An ex vivo permeation study of M-Ext and M-NLC-loaded emulsion was performed through rat skin and the kinetic parameters were determined. Kinetic data showed that the ex vivo permeation of M-NLC-loaded emulsion through rat skin followed the Higuchi model. The safety profile was evaluated in human volunteers after written consent. Three months’ in vivo investigations were conducted using the optimized M-NLC-loaded emulsion and vehicle (B-NLC-loaded emulsion) on human cheeks for comparison. The volunteers’ skin erythema level, melanin contents, TEWL index, moisture contents, sebum level, elasticity, pH, and pore size were examined after the first, second, and third month via noninvasive techniques. There were significant findings for physicochemical characterizations and in vitro and ex vivo studies. The findings demonstrate that the green nanolipid carriers amplified the overall antioxidant effectiveness and may represent an emerging treatment strategy for oxidative stresses and aging.
“…Determination of antioxidant potential will provide an insight regarding the interactions of target compound with biomolecules inside the living cell. Thus, it is useful to study the role of metal oxide nanoparticles as antioxidants because of their current applications and uses in biological systems [ [109] , [110] , [111] ].It has been observed that the antioxidant potential of biofabricated nanoparticles relies on the redox potential of flavonoid and phenolic compounds present on their surface [ 112 , 113 ]. Fig.…”
Section: Antioxidant Activities Of Mycogenic Metallic Nanoparticlesmentioning
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