Impact of menstruation on select hematology and clinical chemistry variables in cynomolgus macaques

Perigard, Christopher J.; Parrula, M. Cecilia M.; Larkin, Matthew H.; Gleason, Carol

doi:10.1111/vcp.12350

Cited by 13 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean hemoglobin, HbF, MCH, RBC, MCV, RDW, eosinophils, bilirubin total, ALP, and creatinine were different between females and males, with most deviations happening after the age of 15 years. This is likely due to the start of the menstruation period, which has also been associated with changes in levels of these parameters in female macaques [31].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Fome¹,

Sangeda²,

Balandya³

et al. 2022

Preprint

View full text Add to dashboard Cite

Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management and evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) in Dar es Salaam, to establish laboratory reference ranges in SCD at steady-state. Patients were grouped into five age groups with respects to their sex. Aggregate functions were used to handle repeated measures within the indi-vidual level in each age group. A nonparametric approach was used to smooth the curves and a parametric approach was used to determine SCD normal ranges. Comparison between males and females and against the general population was documented. Data from 4,422 patients collected from 2004-2015 were analyzed. The majority of the patients (35.41%) were children aged between 5-11 years. There were no significant differences (p≥0.05) in mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils and bilirubin direct observed between males and females. Significant differences (p<0.05) were observed in all selected parameters across age groups except neutrophils and MCHC in adults, as well as platelets and alkaline phosphatase in infants when SCD estimates were compared to the general population. Laboratory reference ranges in SCD at steady-state were different from those of the general population and varied with sex and age. The established reference ranges for SCD at steady-state will be a helpful in the management and monitoring of the progress of SCD.

show abstract

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Fome¹,

Sangeda²,

Balandya³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The mean hemoglobin, HbF, MCH, RBC, MCV, RDW, eosinophils, bilirubin total, ALP, and creatinine were different between females and males, with most deviations happening after the age of 15 years. This is likely due to the start of the menstruation period, which has also been associated with changes in the levels of these parameters in female macaques [27].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Reference Ranges for the Population with Sickle Cell Disease at Steady State in Tanzania

Fome

Sangeda

Balandya

et al. 2022

Hemato

View full text Add to dashboard Cite

Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management and the evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania, to establish laboratory reference ranges among children and adults with SCD at steady state. Patients were grouped into five age groups and according to their sex. Aggregate functions were used to handle repeated measurements within the individual level in each age group. A nonparametric approach was used to smooth the curves, and a parametric approach was used to determine SCD normal ranges. Comparison between males and females and against the general population was documented. Data from 4422 patients collected from 2004–2015 were analyzed. The majority of the patients (35.41%) were children aged between 5–11 years. There were no significant differences (p ≥ 0.05) in mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils, and direct bilirubin observed between males and females. Significant differences (p < 0.05) were observed in all selected parameters across age groups except with neutrophils and MCHC in adults, as well as platelets and alkaline phosphatase in infants when the SCD estimates were compared to the general population. The laboratory reference ranges in SCD at steady state were different from those of the general population and varied with sex and age. The established reference ranges for SCD at steady state will be helpful in the management and monitoring of the progress of SCD.

show abstract

“…The mean of hemoglobin, HbF, MCH, RBC, MCV, RDW, eosinophils, bilirubin total, ALP, and creatinine were different between females and males, with most deviations happening after the age of 15 years. This is likely due to the start of the menstruation period which has also been associated with changes in levels of these parameters in female macaques [26].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Fome¹,

Sangeda²,

Mgaya³

et al. 2021

Preprint

View full text Add to dashboard Cite

Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management and evaluation of interventions. This study was conducted at Mu-himbili National Hospital (MNH) in Dar es Salaam, to establish laboratory reference ranges in SCD at steady-state. Patients were grouped into five age groups with respects to their sex. Aggregate functions were used to handle repeated measures within the indi-vidual level in each age group. A nonparametric approach was used to smooth the curves and a parametric approach was used to determine SCD normal ranges. Comparison between males and females and against the general population was documented. Data from 4,422 patients collected from 2004-2015 were analyzed. The majority of the patients (35.41%) were children aged between 5-11 years. There were no significant differences (p≥0.05) in mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils and bilirubin direct observed between males and females. Significant differences (p<0.05) were observed in all selected parameters across age groups except neutrophils and MCHC in adults, as well as platelets and alkaline phosphatase in infants when SCD estimates were compared to the general population. Laboratory reference ranges in SCD at steady-state were different from those of the general population and varied with sex and age. The established reference ranges for SCD at steady-state will be a helpful in the management and monitoring of the progress of SCD.

show abstract

Impact of menstruation on select hematology and clinical chemistry variables in cynomolgus macaques

Cited by 13 publications

References 13 publications

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Hematological and Biochemical Reference Ranges for the Population with Sickle Cell Disease at Steady State in Tanzania

Hematological and Biochemical Reference Ranges for Population With Sickle Cell Disease at Steady-State in Tanzania

Contact Info

Product

Resources

About