Impact of metabolic syndrome on global left ventricular function: As evaluated by the myocardial performance index

Kumar, Mukesh; Rajasekhar, D.; Vanajakshamma, V.; Latheef, K.

doi:10.1016/j.jsha.2014.03.003

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…A leptina é um hormônio produzido primariamente pelos adipócitos e está associada com a regulação central da saciedade, do metabolismo de energia, além de ser um mediador da fisiopatologia cardiovascular 11,12,13,14 . Da mesma forma, estudos têm observado que a leptina desempenha um papel importante na regulação da respiração, particularmente as respostas ventilatórias para o dióxido de carbono, atuando como um modulador neurohumoral do controle respiratório e nas mudanças da mecânica respiratória 15,16,17,18 41 , prejuízos cardiovasculares 42 , alterações pulmonares 43,44 , aumento do processo inflamatório 45 , disfunção endotelial 46 microalbuminúria 47 e aumento significativo da prevalência de AOS nessa população 48,49 .…”

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Eficiência cardiorrespiratória durante o exercício progressivo em pacientes com síndrome metabólica e apneia obstrutiva do sono

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Eficiência cardiorrespiratória durante o exercício progressivo em pacientes com síndrome metabólica e apneia obstrutiva do sono

Carvalho¹

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Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

Soliman

Nyamandi

Garcia-Patino

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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KM. Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction. Am J Physiol Heart Circ Physiol 309: H70 -H81, 2015. First published April 24, 2015 doi:10.1152/ajpheart.00664.2014.-Obesity is associated with cardiac insulin resistance and contractile dysfunction, which contribute to the development of heart failure. The RhoA-Rho kinase (ROCK) pathway has been reported to modulate insulin resistance, but whether it is implicated in obesity-induced cardiac dysfunction is not known. To test this, wild-type (WT) and ROCK2 ϩ/Ϫ mice were fed normal chow or a high-fat diet (HFD) for 17 wk. Whole body insulin resistance, determined by an insulin tolerance test, was observed in HFD-WT, but not HFD-ROCK2 ϩ/Ϫ , mice. The echocardiographically determined myocardial performance index, a measure of global systolic and diastolic function, was significantly increased in HFD-WT mice, indicating a deterioration of cardiac function. However, no change in myocardial performance index was found in hearts from HFD-ROCK2 ϩ/Ϫ mice. Speckle-tracking-based strain echocardiography also revealed regional impairment in left ventricular wall motion in hearts from HFD-WT, but not HFD-ROCK2 ϩ/Ϫ , mice. Activity of ROCK1 and ROCK2 was significantly increased in hearts from HFD-WT mice, and GLUT4 expression was significantly reduced. Insulin-induced phosphorylation of insulin receptor substrate (IRS) Tyr 612 , Akt, and AS160 was also impaired in these hearts, while Ser 307 phosphorylation of IRS was increased. In contrast, the increase in ROCK2, but not ROCK1, activity was prevented in hearts from HFD-ROCK2 ϩ/Ϫ mice, and cardiac levels of TNF␣ were reduced. This was associated with normalization of IRS phosphorylation, downstream insulin signaling, and GLUT4 expression. These data suggest that increased activation of ROCK2 contributes to obesityinduced cardiac dysfunction and insulin resistance and that inhibition of ROCK2 may constitute a novel approach to treat this condition. ROCK2; insulin signaling; heart; insulin receptor substrate phosphorylation

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Impact of metabolic syndrome on global left ventricular function: As evaluated by the myocardial performance index

Abstract: Metabolic syndrome is a strong predictor of sub-clinical myocardial dysfunction in subjects free of clinically apparent heart disease.

Cited by 2 publications

References 22 publications

Eficiência cardiorrespiratória durante o exercício progressivo em pacientes com síndrome metabólica e apneia obstrutiva do sono

Eficiência cardiorrespiratória durante o exercício progressivo em pacientes com síndrome metabólica e apneia obstrutiva do sono

Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

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