Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia

Ishihara, Kaori; Sasaki, Daisuke; Tsuruda, Kazuto; Inokuchi, Naoko; Nagai, Kazuhiro; Hasegawa, Hiroo; Yanagihara, Katsunori; Kamihira, Shimeru

doi:10.1016/j.canep.2012.07.002

Cited by 47 publications

(27 citation statements)

References 20 publications

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“…Some miRNAs have potential diagnostic value in various cancers [47, 48]. In our study, we found that miR-128 and Bmi-1 can be used as diagnostic markers for gastric cancer, and high levels of miR-128, as well as low levels of Bmi-1, were significantly associated with long overall survival of gastric cancer patients.…”

Section: Discussionsupporting

confidence: 50%

The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer

Jiang

Zhang

et al. 2017

Oncotarget

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miR-128 is expressed in various tumors, but its expression and function in gastric cancer have not been defined. Thus, the goal of this study was to characterize miR-128 in gastric cancer. We found first that miR-128 is down-regulated in gastric cancer cell lines and tissues, and this dysregulation is correlated with DNA methylation and the transcription factor SNAIL. Using prediction tools, western blotting, and luciferase reporter assays, we found that Bmi-1 was the direct target of miR-128. Additionally, overexpression of miR-128 inhibited gastric cancer cell migration, invasion, and proliferation by targeting Bmi-1 in vitro and in vivo. We also documented, with receiver operating characteristic curves and Kaplan-Meier survival analysis, that miR-128 and Bmi-1 may be useful markers for diagnosing and estimating the prognosis of gastric cancer patients. As the epithelial-to-mesenchymal transition is an important mechanism associated with cancer invasion and metastasis, we inferred that miR-128 could regulate this mechanism in gastric cancer. In fact, we found that miR-128 could reverse epithelial-to-mesenchymal transition induced by Bmi-1 via the PI3K/AKT pathway. Because SNAIL also acts as a mesenchymal marker, our findings identified a novel positive feedback loop in which the transcription factor SNAIL curbs the expression of miR-128, and then down-regulated miR-128 promotes the expression of Bmi-1; finally, overexpression of Bmi-1 drives the epithelial-to-mesenchymal transition process via the PI3K/AKT pathway, and the expression of SNAIL is up-regulated.

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Section: Discussionsupporting

confidence: 50%

The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer

Jiang

Zhang

et al. 2017

Oncotarget

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“…Patients were of a variety of carcinomas, including breast cancer, pancreatic ductal adenocarcinomas, esophageal cancer, hepatocellular carcinoma, leukemia, colorectal cancer, lung cancer and lymphoma. Of all the 28 studies, 16 studies (n = 2536) with HR data could be included for metaanalysis [7,[13][14][15][16][17][18][33][34][35][36][37][38][39][40][41]. Among them, seven studies (n = 1678) recruited lung cancer patients.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

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Abstract. BACKGROUND:Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

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“…Several studies have corroborated this finding in lung cancer and other malignant diseases including colorectal cancer, breast cancer, hepatocelluar carcinomas, pancreatic ductal adenocarcinomas and adult T-cell leukemia (Raponi et al, 2009;Greither et al, 2010;Shibuya et al, 2010;Chen et al, 2012;Han et al, 2012;Huang et al, 2012;Ishihara et al, 2012;Papaconstantinou et al, 2012); however, other reports provided insignificant or opposite evidences (Jung et al, 2009;Voortman et al, 2010;Donnem et al, 2011;Saito et al, 2011;Monsálvez et al, 2012;Shinmei et al, 2012). In order to investigate the precise association between miR-155 expression and the prognosis of patients, we combined the HRs extracted from the eligible data, and found that patients with high miR-155 expression were likely to have an unfavorable outcome.…”

Section: Has Prognostic Value In Patients With Nsclcs and Digestive Smentioning

confidence: 87%

MicroRNA-155 Expression has Prognostic Value in Patients with Non-small Cell Lung Cancer and Digestive System Carcinomas

Xu¹,

Zhu²,

Zhang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia

Cited by 47 publications

References 20 publications

The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer

The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

MicroRNA-155 Expression has Prognostic Value in Patients with Non-small Cell Lung Cancer and Digestive System Carcinomas

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