Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial

Abstract

Background: Recently some plasma biomarkers of inflammation have been recognized as important cardiovascular risk factors. There is little information about the effects of aerobic exercise training on these biomarkers and the risk of metabolic complications in obese type 2 diabetes patients. Objective: To compare the impact of moderate versus mild aerobic exercise training on the inflammatory cytokines in obese type 2 diabetic patients. Methods: Fifty obese type 2 diabetic patients of both sexes with body mass index (BMI) varying from 31 to 36 kg/m 2 , non smokers, free from respiratory, kidney, liver, metabolic and neurological disorders, participated in this study. Their age ranged from 40 to 55 years. The subjects were included into two equal groups; the first group (A) received moderate aerobic exercise training. The second group (B) received mild aerobic exercise training, three times / week for 3 months. Results:The mean values of leptin, TNF-alpha, IL2, IL4, IL6, HOMA-IR and HBA1c were significantly decreased in group (A) and group (B). Also, there were significant differences between both groups after treatment. Conclusion: Moderate aerobic exercise training modulates inflammatory cytokines more than mild aerobic exercise training in obese type 2 diabetic patients.

The effects of three different exercise modalities on markers of male reproduction in healthy subjects: a randomized controlled trial

“…However, there is some evidence that aerobic exercise training is anti-inflammatory, and moderate-intensity aerobic exercise has been shown to attenuate the circulating markers of inflammation in both healthy and diseased populations (Tartibian et al 2011, Abd El-Kader et al 2013. Recently, a 3-month randomized trial aerobic exercise training showed reduced plasma concentrations of TNF-α, IL-2 and IL-6 among obese type 2 diabetic patients (Abd El-Kader et al 2013).…”

“…However, there is some evidence that aerobic exercise training is anti-inflammatory, and moderate-intensity aerobic exercise has been shown to attenuate the circulating markers of inflammation in both healthy and diseased populations (Tartibian et al 2011, Abd El-Kader et al 2013. Recently, a 3-month randomized trial aerobic exercise training showed reduced plasma concentrations of TNF-α, IL-2 and IL-6 among obese type 2 diabetic patients (Abd El-Kader et al 2013). Likewise, previous studies have also shown decreases in serum C-reactive protein (CRP), prostaglandin (PG) E 2 , TNF-α, IL-6 and IL-8 levels with 16 and 24 weeks of moderate-intensity aerobic exercise training in postmenopausal women (Tartibian et al 2011(Tartibian et al , 2015.…”

Envelhecimento saudável e atividade física: uma revisão sistemática sobre os efeitos do exercício nas doenças cardiovasculares

“…Em todos os estudos o processo de randomização foi descrito e em 10 ECR a sequência de alocação foi descrita [25][26][27][28][29][30]33,35,37,42]. O processo de cegamento dos participantes, cuidadores e avaliadores foi descrito em oito estudos [11,18,26,27,32,38,41,43]. Nenhum dos estudos apresentou a descrição dos processos de cegamento dos resultados.…”

“…O cálculo do tamanho amostral não foi apresentado consistentemente nos artigos, tornando difícil a interpretação dos achados devido ao poder insuficiente em seis estudos [32,40,[43][44][45][46]. A intervenção foi baseada em exercícios aeróbios em sete estudos [25,28,30,33,36,37,43] com duração entre 30 e 75 minutos por sessão com intensidades entre 50 e 85% do VO 2 máximo e entre 65 e 75% da frequência cardíaca máxima (FCM).…”

Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitus

“…12 Exercise training reduces pro-inflammatory biomarkers, 13 with several studies reporting that moderate intensity exercise decreases inflammation compared to low intensity exercise. 14,15 However, the effects of higher intensity aerobic exercise on inflammatory biomarkers in patients with…”