Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish ( Danio rerio ) challenged with Aeromonas hydrophila

Hu, Zhenyu; Wu, Bingqian; Meng, Fanying; Zhou, Zejian; Lü, Hui; Zhao, Heng

doi:10.1016/j.fsi.2017.05.066

Cited by 32 publications

(16 citation statements)

References 36 publications

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“…At present, there is only a temporal connection between hydrogen and improvement of this patient’s cancer. The proposed mechanism underlying the anti-cancer properties of hydrogen may involve: (1) Elimination of the high levels of ROS produced by cancer cells, thus inhibiting the proliferation, invasion, and migration of cancer cells[31]; (2) Downregulation of inflammatory factors, elimination of chronic inflammation, and modification of the microenvironment[32]; (3) Protection of mitochondria, which maintains energy generation and help correct hypoxia, thereby transforming the cardiovascular, endocrine, and nervous systems[11]; and (4) Restoration of the function of exhausted cytotoxic T cells, and enhancement of systemic anti-cancer effects[33]. The detailed mechanism remains to be fully elucidated in further follow-up studies, and indications for advanced cancer therapy require verification in studies with greater numbers of patients.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Chen

Pan

et al. 2019

WJCC

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BACKGROUND We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the pancreas. The patient had severe anemia, requiring weekly blood transfusions. The gallbladder tumor invaded the descending part of the duodenum, causing intestinal leakage and hepatic colonic adhesion. CASE SUMMARY The patient refused other treatments and began daily hydrogen inhalation therapy. After 1 mo of treatment, the gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. After continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support, the intestinal obstruction was gradually relieved. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life. CONCLUSION This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months.

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Section: Discussionmentioning

confidence: 99%

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Chen

Pan

et al. 2019

WJCC

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“…Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila, Fish Shellfish Immunol. Aug; 67: 554-560 [43]. The used fish was a zebra fish (around 5 cm).…”

Section: Resultsmentioning

confidence: 99%

Study on the Possibility of Mixed Water as a Drinking Water<br/>—From the Viewpoint of the Formation of Hydrogen-Rich Water

Hiratsuka¹,

Yasuda²

2021

JWARP

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In exploring an autonomous independent water supply system, authors have realized the importance of the sustainable water supply utilizing regional features in isolated islands. This paper is further study from the previous one. This time we have narrowed down the mixing rate of mixed water. In this study, the mixed water less than 0.74% (blood concentration) has been prepared first, and then divided it into five kinds of the mixing rate of mixed water. And we have compared and examined the characteristics of the mixed water from the viewpoint of the relationship between salinity and pH, ORP and that of Dissolved Hydrogen, and examined the possibility of mixed water as a drinking water. As a result, we have obtained the new findings that suggest the possibility.

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“…Once induced, they trigger a disease-resistant response of the immune system and help enhance the immune response. Therefore, NO and cytokines are frequently detected in immune responses, an observation being reported by an increasing number of immunologists (37,52). For instance, dietary loquat leaf extract supplementation significantly upregulated immune-related genes in the intestine and improves innate immune responses (53).…”

Section: Discussionmentioning

confidence: 98%

The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L

et al. 2020

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The effects of the oral administration of Rehmannia glutinosa polysaccharide (RGP-1) on the immunoregulatory properties, antioxidant activity, and resistance against Aeromonas hydrophila in Cyprinus carpio L. were investigated. The purified RGP-1 (250, 500, and 1,000 µg/mL) was co-cultured with the head kidney cells of the common carp. The proliferation and phagocytosis activities of the head kidney cells, and the concentration of nitric oxide (NO) and cytokines in the culture medium were determined. Next, 300 common carps (47.66 ± 0.43 g) were randomly divided into five groups; the two control groups (negative and positive) were administered sterile PBS and the three treatment groups were administered different concentrations of RGP-1 (250, 500, and 1,000 µg/mL) for seven days. Subsequently, the positive and treatment groups were infected with A. hydrophila, and the negative group was administered sterile PBS for 24 h. The concentration of NO, cytokines, lysozyme (LZM), and alkaline phosphatase (AKP) in serum, the total antioxidant capacity (T-AOC), the levels of malonaldehyde (MDA) and glutathione (GSH), and the total activities of superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the hepatopancreas of the common carp were tested. We observed that RGP-1 could significantly enhance the proliferation and phagocytosis activities (P < 0.05), besides inducing the production of NO, pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-12) and anti-inflammatory cytokines (IL-10, TGF-β) (P < 0.05) in vitro. The in vivo experimental results revealed that RGP-1 significantly enhanced NO production, protein levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-12), LZM and AKP activities, and the antioxidant content (T-AOC, SOD, CAT, GSH, GSH-Px, and MDA) compared to that observed in the negative group prior to A. hydrophila infection (P < 0.05). NO, pro-inflammatory cytokines, LZM Feng et al. RGP-1 as Immunostimulant in Commom Carp and AKP activities were significantly lower than that in the positive group after infection (P < 0.05). However, whether infected or not, the expression of anti-inflammatory cytokines (IL-10, TGF-β) increased significantly in the RGP-1-treated groups (P < 0.05). Therefore, the results suggested that RGP-1 could enhance the non-specific immunity, antioxidant activity and anti-A. hydrophila activity of the common carp, and could be used as a safe and effective feed additive in aquaculture.

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Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish ( Danio rerio ) challenged with Aeromonas hydrophila

Cited by 32 publications

References 36 publications

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Study on the Possibility of Mixed Water as a Drinking Water<br/>—From the Viewpoint of the Formation of Hydrogen-Rich Water

The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L

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Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish ( Danio rerio ) challenged with Aeromonas hydrophila

Cited by 32 publications

References 36 publications

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Study on the Possibility of Mixed Water as a Drinking Water&lt;br/&gt;—From the Viewpoint of the Formation of Hydrogen-Rich Water

The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L

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Study on the Possibility of Mixed Water as a Drinking Water<br/>—From the Viewpoint of the Formation of Hydrogen-Rich Water