Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

Abstract

We report the construction of two types of core-shell tecto dendrimers (CSTDs) with different core rigidities to illustrate the impact of molecular rigidity on their gene delivery efficiency. Our study...

Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo

“…As previously reported in our group, we found that cationic phosphorus dendrimers, as a kind of gene carrier, had strong gene compression and protection abilities. We also showed that core–shell tecto dendrimers with rigid cores displayed better gene compaction and delivery efficiency than the counterparts with flexible cores . However, due to the strong rigidity of the phosphorous dendrimers, their hydrophobic cavity does not have drug retention ability, thus limiting their drug delivery applications.…”

“…We also showed that core−shell tecto dendrimers with rigid cores displayed better gene compaction and delivery efficiency than the counterparts with flexible cores. 37 However, due to the strong rigidity of the phosphorous dendrimers, their hydrophobic cavity does not have drug retention ability, thus limiting their drug delivery applications. Therefore, it is crucial to design amphiphilic phosphorus dendrons, an analogue of phosphorous dendrimers that can self-assemble to form micelles in aqueous solution for drug delivery applications.…”

Amphiphilic phosphorous dendron micelles co-deliver microRNA inhibitor and doxorubicin for augmented triple negative breast cancer therapy

“…16,22,23 The reported dendritic polymers based on PAMAMs have a quite flexible molecular structure, which is not ideal for enhanced gene delivery. In a very recent study, 24 we have shown that core-shell tecto dendrimers possessing rigid core of phosphorous dendrimers and PAMAM shell dendrimers display much more enhanced gene compression and delivery efficiency than the counterpart having both PAMAM core and shell dendrimers. Very recently, we have shown that amphiphilic phosphorous dendrons with either negatively charged tyramine-bearing two dimethylphosphonate sodium salt 25 or positively charged protonated pyrrolidine moieties 26 can be used to encapsulate hydrophobic drugs to fight inflammatory disease or cancer.…”

Ultrasound-enhanced theranostics of orthotopic breast cancer through a multifunctional core–shell tecto dendrimer-based nanomedicine platform

“…Recently, much effort has been devoted to exploit core–shell tecto dendrimers (CSTDs) for cancer nanomedicine application. 27 Compared to single-generation dendrimers, CSTDs that are formed based on host–guest recognition between β-cyclodextrin (β-CD) and adamantane (Ad) 28 have abundant surface amine groups and large internal cavities. This is beneficial for them to have higher gene transfection 29 and drug loading efficiency, 7,30 stronger r 1 relaxivity after gadolinium( iii ) (Gd( iii )) chelation, and a more significantly enhanced EPR effect for passive tumor accumulation 31 than the single generation dendrimer-based platform.…”