Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva

Knaś, Małgorzata; Maciejczyk, Mateusz; Sawicka, Katarzyna; Hady, Hady Razak; Niczyporuk, Marek; Ładny, Jerzy Robert; Matczuk, Jan; Waszkiel, Danuta; Żendzian-Piotrowska, Małgorzata

doi:10.1111/jop.12383

Cited by 57 publications

(64 citation statements)

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“…Antioxidants not only inhibit ROS-induced oxidation but also repair some forms of oxidative modification in biomolecules. The most important blood antioxidants include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and uric acid (UA) [7,8,11]. It is suggested that antioxidant supplementation could reduce metabolic disorders and improve the condition of obese patients.…”

Section: Introductionmentioning

confidence: 99%

“…However, the exact reason for these changes is still unknown. It is postulated that the improvement of obese patients is associated with the reduction of oxidative stress levels [7,8,11]; however, there is no longitudinal data about the redox homeostasis of patients undergoing bariatric treatment. Therefore, the aim of our study was to evaluate the impact of morbid obesity as well as huge weight loss on the blood antioxidant systems/oxidative stress before as well as one, three, six and twelve months after bariatric surgery.…”

Section: Introductionmentioning

confidence: 99%

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A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Choromańska

Myśliwiec

Łuba

et al. 2020

JCM

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This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Choromańska

Myśliwiec

Łuba

et al. 2020

JCM

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“…Diversas comorbidades são associadas a obesidade, como a hipertensão arterial, diabetes Mellitus tipo II, arteriosclerose, artrite, síndrome da apneia do sono, disfunções endócrinas, câncer, problemas psicossociais, econômicos e problemas bucais. Dentre as principais manifestações bucais pode-se citar periodontite, xerostomia, cárie dentária e lesões erosivas (SAPORITI et al, 2014;KNAS et al, 2016;SALES-PERES et al, 2017).…”

Section: Introductionunclassified

“…Alagoas; E-mail: laisnobree@hotmail.com; (3) Professor de Odontologia e do Mestrado Profissional Pesquisa em Saúde do Centro Universitário CESMAC; (4) Pós-doutorando da Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo; E-mail: rodrigoneves.rn@hotmail.com; (5) Professor de Odontologia e do Mestrado Profissional Pesquisa em Saúde do Centro Universitário CESMAC; E-mail: diego_duke@hotmail.com; (6) Doutoranda, Faculdade de Odontologia São Leopoldo Mandic, Campinas, São Paulo; E-mail: sylalbuquerque@hotmail.com; (7) Professor de Odontologia e do Mestrado Profissional Pesquisa em Saúde do Centro Universitário CESMAC; Professor da disciplina de Cariologia da Faculdade de Odontologia da Universidade Federal de Alagoas; E-mail: nbs.odonto@hotmail.com Todo o conteúdo expresso neste artigo é de inteira responsabilidade dos seus autores.…”

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“…uma das doenças que apresenta maior incidência em todo o mundo e trás consigo uma série de comorbidades que afetam negativamente a saúde geral. Além disso, existe uma relação entre a obesidade e problemas na cavidade oral (CUMMINGS e PRATT, 2015;SALES.Dentre os problemas bucais encontrados em pacientes com obesidade mórbida podemos destacar a doença periodontal e a xerostomia, proveniente dos medicamentos utilizados para combater doenças que surgem como consequência da obesidade (hipertensão e diabetes)(SAPORITI et al, 2014;JAISWAL et al, 2015;KNAS et al, 2016;SALES-PERES et al, 2017). Outra consequência é a cárie dentária, que surge devido ao consumo excessivo e frequente de alimentos ricos em açúcar e de gorduras saturadas associados à uma higiene oral precária e as lesões erosivas, decorrentes do refluxo gastroesofágico e dos transtornos alimentares (bulimia e anorexia nervosa)(GONÇALVES et al, 2010;PATARO et al, 2016).Existem diversos tipos de tratamentos para a obesidade.…”

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Cirurgia bariátrica e suas repercussões na saúde bucal: uma revisão de literatura

Santos¹,

Nobre²,

Silva³

et al. 2019

Div Journ

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RESUMO: O objetivo desta revisão foi discutir a relação de alterações na cavidade bucal como resultado da cirurgia bariátrica. As bases de dados eletrônicas, Pubmed, Medline,, Scielo, Lilacs e Periódicos CAPES foram utilizadas para busca eletrônica de artigos indexados, sem restrição de data de publicação ou idioma, que relacionasse a cirurgia bariátrica, obesidade e cavidade oral. A literatura cinzenta foi pesquisada no banco de dados OpenGrey. As referências dos artigos selecionados desta revisão também foram pesquisadas. Os descritores foram utilizados baseados no MESH: Bariatric surgery AND oral health , tooth wear, dental caries, salivar flow Incluiu-se estudos com humanos, coorte, caso-controle, longitudinais, relato de caso, ensaios clínicos. Foram excluídas as duplicatas. Após a leitura dos títulos e resumos, 43 artigos selecionados para leitura integral do texto. Dos estudos lidos, 29 relacionaram a cirurgia bariátrica com alterações na cavidade oral, sendo a cárie dentária, erosão dental, doença periodontal e hipossalivação as mais prevalentes. Dois estudos apresentaram em seus resultados a melhora da condição de saúde bucal como resultado da cirurgia bariátrica. Diante do que foi discutido é necessário que o cirurgião-dentista participe da equipe multidisciplinar que acompanha os pacientes obesos que se submeterão à cirurgia bariátrica, contribuindo para a diminuição de efeitos bucais e aumento da qualidade de vida. ABSTRACT:The purpose of this review was to discuss the relationship of changes in the oral cavity as a result of bariatric surgery. The scientific databases, Pubmed, Medline, Scielo, Lilacs and CAPES database were used for electronic search for indexed articles, without restriction to date of publication or published language restriction, that had correlated bariatric surgery, obesity and oral cavity. The gray literature was searched in the OpenGrey database. References of selected articles to this review were also searched. The descriptors were used according to the MESH: Bariatric surgery AND oral health, tooth wear, dental caries, salivary flow. It was included studies with human, cohort, case-control, longitudinal, case report, and clinical trials. Duplicates were excluded. After reading the titles and abstracts, 43 articles were selected for the full text reading. Of the read studies, 29 related bariatric surgery with alterations in the oral cavity, being the most prevalent dental caries, dental erosion, periodontal disease and hyposalivation. Two studies showed improved oral health status as a result of bariatric surgery. Faced with what has been discussed, it is necessary that the dental surgeon participates in the multidisciplinary team that accompanies obese patients who will undergo bariatric surgery, contributing to a decrease in oral effects and an increase in quality of life.

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Oral health profile of postbariatric surgery individuals: A case series

Taghat

Mossberg

Lingström

et al. 2021

Clinical & Exp Dental Res

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Objectives: To describe the oral health profile of individuals who had undergone gastric bypass surgery (GBP) or sleeve gastrectomy (SG) to generate hypotheses for further studies.Material and Methods: Fourteen individuals treated with GBP or SG surgery ≥ 2 years ago and with observed and/or perceived oral problems were recruited to a case series. The documentation included clinical and radiographic examinations, biomedical sampling, and self-reported diet and questionnaires. The results are presented descriptively.Results: The age range was 31 to 66 years and all had a BMI > 25 (range 25.4-44.7).Only four participants were fully dentate. Eleven out of 14 individuals exhibited severe decay. A majority had poor oral hygiene and high bacterial counts. The flow rates of unstimulated saliva were extremely low and hyposalivation was present in ten of the fourteen cases. Most perceived several oral health problems, such as chewing difficulty and tooth hypersensitivity.Conclusions: Individuals who had undergone GBP or SG surgery had poor clinically diagnosed oral health and perceived oral health problems. Longitudinal studies are needed to monitor the patients' oral health, from before bariatric surgery to longterm postoperatively.bariatric surgery, case series, oral health | INTRODUCTIONObesity is a global health issue today with worldwide rates tripling since 1975. In 2016, 650 million adults (13%) were reported as obese that is, a Body Mass Index (BMI) greater than or equal to 30 kg/m 2 (WHO, 2020). The corresponding proportion in Sweden is 15%, according to a recent national health survey (The Public Health Agency of Sweden, 2018). Obesity is considered a risk factor for an array of chronic diseases (The Global Burden of Disease 2015 Collaborators, 2017) however, studies on the association between an obese condition and oral disease show somewhat contradictory results and causal relationships are not well established (Nascimento et al., 2016;Shivakumar, Srivastava, & Shivakumar, 2018).Obesity is difficult to treat despite several treatment options, including reduced dietary energy intake, physical activity,

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Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva

Abstract: In morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment.

Cited by 57 publications

References 32 publications

A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Cirurgia bariátrica e suas repercussões na saúde bucal: uma revisão de literatura

Oral health profile of postbariatric surgery individuals: A case series

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