Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Chansangpetch, Sunee; Panpruk, Rawiphan; Manassakorn, Anita; Tantisevi, Visanee; Rojanapongpun, Prin; Hurst, Cameron; Lin, Shan

doi:10.1167/iovs.17-22219

Cited by 37 publications

(41 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chang’s study pointed out that the axial elongation led to corneal flattening and thickness reduction [ 35 ], suggesting that the increase of axial length may affect the biomechanics of the cornea and previous studies have proved this. Myopia in glaucoma and normal eyes would lead to biomechanical parameters changes such as corneal deformation amplitude (CDA), outward corneal applanation (OCA) and cornea stiffness (CS) [ 36 , 37 ]. Especially the cornea in high myopia had faster outward corneal velocity (OCV) and higher CDA compared to emmetropia [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

et al. 2020

View full text Add to dashboard Cite

Background To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. Methods A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. Results The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each). Conclusions SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

show abstract

Section: Discussionmentioning

confidence: 99%

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although most of the refractive error associated with myopia comes from the axial length, it is increasingly recognised that changes of the anterior segment in high myopia lead to significant optical and higher order aberrations 60. A potentially interesting aspect is the study of biomechanical changes associated with corneal thickness in high myopia, which may affect the evaluation of intraocular pressure61 and diagnosis of glaucoma—elaborated further later in this review 62. However, current studies have variable results due to the different imaging techniques and the technological limitations in measuring on the biomechanical changes of the cornea associated with increasing myopia 63…”

Section: Introductionmentioning

confidence: 94%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

View full text Add to dashboard Cite

Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.

show abstract

“…16,22 For example, most prior studies included glaucoma patients with high baseline 18,19 or relatively high treated IOP. 16,17,22 In a previous study, we demonstrated the greater compliance of glaucoma eyes compared with healthy eyes after controlling for these confounding effects. 23 However, because most previous studies, including ours, enrolled glaucoma patients under medical treatment, the question remains unanswered as to whether biomechanical alterations in glaucoma eyes were caused by glaucoma per se, medications for glaucoma, or both.…”

mentioning

confidence: 99%

Dynamic Scheimpflug Ocular Biomechanical Parameters in Untreated Primary Open Angle Glaucoma Eyes

Miki

Yasukura

Weinreb

et al. 2020

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

To characterize the corneal biomechanical properties of glaucoma eyes by comparing the dynamic Scheimpflug biomechanical parameters between untreated glaucoma and control eyes. METHODS. Cross-sectional observational data of dynamic Scheimpflug analyzer (Corvis ST) examinations were retrospectively collected from 35 eyes of 35 consecutive patients with untreated normal tension glaucoma and 35 eyes of 35 healthy patients matched on age and IOP. Ten biomechanical parameters were compared between the two groups using multivariable models adjusting for IOP, central corneal thickness, age, and axial length. The Benjamini-Hochberg method was used to correct for multiple comparison. RESULTS. In multivariable models, glaucoma was associated with smaller applanation 1 time (P < 0.001, coefficient = −0.5865), applanation 2 time (P = 0.012, coefficient = −0.1702), radius (P = 0.006, coefficient = −0.5447), larger peak distance (P = 0.011, coefficient = 0.1023), deformation amplitude ratio at 1 mm (P < 0.001, coefficient = 0.072), and integrated radius (P < 0.001, coefficient = 1.094). These associations consistently indicate greater compliance of the cornea in glaucoma eyes. CONCLUSIONS. Untreated normal tension glaucoma eyes were more compliant than healthy eyes. The greater compliance (smaller stiffness) of normal tension glaucoma eyes may increase the risk of optic nerve damage. These results suggest the relevance of measuring biomechanical properties of glaucoma eyes.

show abstract

Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Cited by 37 publications

References 32 publications

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

Imaging in myopia: potential biomarkers, current challenges and future developments

Dynamic Scheimpflug Ocular Biomechanical Parameters in Untreated Primary Open Angle Glaucoma Eyes

Contact Info

Product

Resources

About