As a global public health concern for almost three years, Coronavirus Disease 2019 caused by different strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the transmission characteristics vary among counties, regions and virus variants. This paper investigates the synergy between the changes in the exposure to the main outdoor air pollutants (particulate matter PM2.5 and PM10, NO2, SO2, CO, and O3), and meteorological-related factors, which may exacerbate the SARS-CoV-2 viral'effect on human health and the COVID-19 incidence and lethality in Bucharest. Through applied statistical analyses of average daily in-situ and satellite time series data recorded during several seasons and over a long time period (1 March 2020-1 April 2022), during five COVID-19 pandemic waves, this study provides an accurate estimation of the local and regional mutual seasonality of the air quality and epidemiologic conditions impacts of the COVID-19 disease evolution in Bucharest metropolitan city. This study found a positive correlation between the main air pollutants (PM2.5, PM10; NO2, CO and SO2) and confirmed cases of COVID-19 caused by different SARS-CoV-2 strains. An opposite correlation was found for at the ground level ozone-O3. In spite of spring 2020 total lockdown, or other restriction periods associated with the COVID-19 waves, aerosol loading over Bucharest metropolis did not record significant reduction in comparison with the pre-pandemic period. This study could provide valuable information into epidemic viral diseases control strategies to limit urban air pollution, especially during synoptic anticyclonic active systems.