Impact of Nephron&amp;ndash;Sparing Surgery on Quality of Life in Patients with Localized Renal Cell Carcinoma

Shinohara, Nobuo; Harabayashi, Toru; Sato, Soshu; Hioka, Takaya; Tsuchiya, Kunihiko; Koyanagi, Tomohiko

doi:10.1159/000052422

Cited by 60 publications

(53 citation statements)

References 18 publications

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“…Quality of life, however, was superior for patients with more parenchyma remaining after surgery. Shinohara et al also evaluated the impact of nephronsparing surgery on quality of life in 66 patients with localized renal cell carcinoma, compared with radical nephrectomy using the EORTC QLQ-C30 [11]. Patients who underwent nephron-sparing surgery showed higher physical function scores than patients treated with radical nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Quality of life aspects in kidney cancer patients: data from a national registry

Anastasiadis

Davis

Sawczuk

et al. 2003

Supportive Care in Cancer

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This is the first study in which sexual function in patients with renal cancer has been addressed. While most patients remain sexually active in non-distressed relationships, many reported depressive symptoms, and sexual functioning may be worse than in comparable chronically ill populations. Quality of life and sexual function issues should be addressed when counseling urological cancer patients.

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Section: Discussionmentioning

confidence: 99%

Quality of life aspects in kidney cancer patients: data from a national registry

Anastasiadis

Davis

Sawczuk

et al. 2003

Supportive Care in Cancer

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“…Cancer-specific death was assessed in five of the included studies [6,16,19,20,23]. The test of heterogeneity indicated that there was no significant heterogeneity (I 2 = 30.0%, P = 0.22) among these studies.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies [15,17-19,21,22] assessed the patient complications. The test of heterogeneity indicated a significant heterogeneity (I 2 = 71.0%, P <0.01) among these studies.…”

Section: Resultsmentioning

confidence: 99%

Clinical efficacy of radical nephrectomy versus nephron-sparing surgery on localized renal cell carcinoma

Cheng

et al. 2014

Eur J Med Res

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BackgroundThe aim of the present study was to compare the clinical efficacy of radical nephrectomy (RN) with nephron-sparing surgery (NSS) in treating patients with localized renal cell carcinoma (RCC).MethodsThe literature search was performed in PubMed, MEDLINE Springer, Elsevier Science Direct, Cochrane Library, and Google Scholar up to December 2012. The software Review Manager 5.1 and the STATA software package v.11.0 were used for analyses. The odds ratios (ORs) and its 95% confidence interval (95% CI) were calculated for comparison. Subgroup analyses were performed based on the tumor size of RCC.ResultsIn total, 10 studies with 10,174 RCC patients (7,050 treated with RN and 3,124 treated with NSS) were selected. The pooled estimate (OR = 1.58, 95% CI = 1.15–2.15, P = 0.004) showed a significantly lower rate of cancer-specific deaths in the patients treated with NSS compared to RN. However, no statistically significant differences were found in the rate of tumor recurrence (OR = 0.84, 95% CI = 0.67–1.06, P = 0.14) and complications (OR = 0.91, 95% CI = 0.51–1.63, P = 0.74) between the patients treated with NSS and RN. In addition, all the subgroup analyses presented consistent results with the overall analyses.ConclusionsNSS had no significantly different from RN in tumor recurrence and complications for localized RCC. However, the significantly lower rate of cancer-specific deaths supported the use of NSS not only for RCC with tumor size >4.0 cm but also for tumor sizes ≤4.0 cm compared with RN.

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“…The main advantage of NSS over radical nephrectomy is preservation of the function of the affected kidney after the operation [7,9,10]. Thus, it is crucial to make every possible maneuver to prevent nephron damage during the operation.…”

Section: Introductionmentioning

confidence: 99%

A new technique—“lipocorticoplasty”—for the closure of partial nephrectomy defects and its comparison with the standard technique

et al. 2011

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Impact of Nephron–Sparing Surgery on Quality of Life in Patients with Localized Renal Cell Carcinoma

Cited by 60 publications

References 18 publications

Quality of life aspects in kidney cancer patients: data from a national registry

Quality of life aspects in kidney cancer patients: data from a national registry

Clinical efficacy of radical nephrectomy versus nephron-sparing surgery on localized renal cell carcinoma

A new technique—“lipocorticoplasty”—for the closure of partial nephrectomy defects and its comparison with the standard technique

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