2023
DOI: 10.3897/pharmacia.70.e94246
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Impact of nitric oxide synthesis modulators on the state of humoral immune system in experimental antiphospholipid syndrome

Abstract: Background: Antiphospholipid syndrome is an autoimmune disease of multiple venous and/or arterial thrombosis and/or pregnancy loss. Oxidative stress only enhances the body’s immune response. In pathological conditions, the formation of nitric oxide is disrupted, which can be manifested by vasoconstriction, increased coagulation, and endothelial dysfunction. Objective: The aim of the research was to study the level of immunoglobulins and circulating immune complexes (CICs) in experimental antiphosphol… Show more

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Cited by 5 publications
(2 citation statements)
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“…Modern research has proven the dualism of the effects of thyroid hormones on bone metabolism. Metabolic disorders lead to the fact that all patients with diffuse toxic goiter, even in the early stages of the disease, have inflammatory-dystrophic changes in the periodontium [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…Modern research has proven the dualism of the effects of thyroid hormones on bone metabolism. Metabolic disorders lead to the fact that all patients with diffuse toxic goiter, even in the early stages of the disease, have inflammatory-dystrophic changes in the periodontium [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…NO regulates several physiological processes, including thrombosis, endothelial-leukocyte interactions, vascular cell migration and proliferation, as well as modulation of vascular tone and permeability. In norm, NO is synthesized in the vascular wall owing to the endothelial isoform of NO synthase (eNOS) [11,12,13]. The role of NO in the pathogenesis of APS is associated with both direct and indirect action.…”
mentioning
confidence: 99%