Impact of Nocturia on Mortality: The Nagahama Study

Funada, Satoshi; Tabara, Yasuharu; Setoh, Kazuya; Negoro, Hiromitsu; Akamatsu, Shusuke; Yoshino, Takayuki; Yoshimura, Koji; Watanabe, Norio; Furukawa, Toshi A; Matsuda, Fumihiko; Ogawa, Osamu

doi:10.1097/ju.0000000000001138

Cited by 22 publications

(40 citation statements)

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“…Second, selection bias might have occurred since this study was only performed in Nagahama city with a Japanese rural population, and participants were not recruited randomly but voluntarily. An aim of the Nagahama study is for preventive medicine, therefore the participants were supposed to be healthier than the nonparticipants, and indeed, the mortality rate of the participants of the Nagahama study was lower than that of the general population in Japan 27 . It is necessary to validate the relationship between childhood enuresis and adult nocturia in other cohort studies in different areas and countries to strengthen the conclusion of this study.…”

Section: Discussionmentioning

confidence: 93%

Medical history of nocturnal enuresis during school age is an independent risk factor for nocturia in adults: The Nagahama study

Negoro

Fukunaga

Setoh

et al. 2020

Neurourology and Urodynamics

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Aim: To evaluate the relationship between nocturia and medical history of nocturnal enuresis: two conditions where diurnal urination rhythm is disturbed. Methods: The Nagahama study is a longitudinal population-based health survey involving people aged 30-75 years in Nagahama city, Japan. Our analysis included 5,402 participants who completed enuresis and International Prostate Symptom Score questionnaires. Associations between nocturnal enuresis and nocturia were evaluated cross-sectionally and longitudinally with three models: (1) univariate analysis; (2) adjusted for basic characteristics (e.g., age, sex, body mass index, activity, alcohol, and smoking); and (3) adjusted for basic and clinical variables (e.g., hyperglycemia, hyperlipidemia, hypertension, renal insufficiency, insomnia, obstructive sleep apnea, and mental health). Results: In total, 1,613 participants (29.9%) had a medical history of enuresis. The mean night-time frequency was 0.73 at baseline and 0.85 at the 5-year follow-up. The cross-sectional analysis showed participants with a medical history of enuresis had night-time frequency more often than those without this history (0.84 vs. 0.68, p < .0001). Significant differences were observed in Models 2 (p < .0001) and 3 (p < .0001). The longitudinal analysis showed nocturia progression was significantly related to a history of enuresis, with odds ratios of 1.32 (p < .0001) in Model 1, 1.21 (p < .01) in Model 2, and 1.22 (p < .01) in Model 3. Conclusions: Medical history of enuresis during school age was significantly related to nocturia in adulthood in the cross-sectional analysis, and to

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Section: Discussionmentioning

confidence: 93%

Medical history of nocturnal enuresis during school age is an independent risk factor for nocturia in adults: The Nagahama study

Negoro

Fukunaga

Setoh

et al. 2020

Neurourology and Urodynamics

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“…Recently, nocturia, which is a common lower urinary tract symptom in older people, has been found to be not only a cause of decreased quality of life, but also a risk factor for depression and death 6 , 7 . The causes of nocturia include global polyuria, nocturnal polyuria, bladder storage problems, and sleep disorders 18 , of which the most common cause is nocturnal polyuria 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Nocturia is a common lower urinary tract symptom in older people, and its incidence is estimated to be > 60% in older people aged > 65 years 4 . Nocturia is not only a troublesome symptom that affects quality of life 5 but has also recently been shown to be a risk factor for depression and death 6 , 7 . Therefore, treating nocturia may improve the quality of life in older people and reduce the risk of depression and death.…”

Section: Introductionmentioning

confidence: 99%

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Takezawa

Kuribayashi

Okada

et al. 2021

Sci Rep

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To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (both P < 0.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion.Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry).Date of registration: From 1 June 2019 to 31 October 2020.

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“…Recently, nocturia, which is a common lower urinary tract symptom in older people, has been found to be not only a cause of decreased quality of life, but also a risk factor for depression and death [6,7]. The causes of nocturia include global polyuria, nocturnal polyuria, bladder storage problems, and sleep disorders [15], of which the most common cause is nocturnal polyuria [2].…”

Section: Discussionmentioning

confidence: 99%

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Takezawa

Kuribayashi

Okada

et al. 2021

Preprint

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Purpose: To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction.Methods: Patients who underwent laparoscopic nephrectomy were studied prospectively. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day two and postoperative day seven. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated by multiple linear regression analysis.Results: Forty-nine patients were included. The eGFR decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg (P < 0.01) and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (P < 0.01) with nephrectomy. Multiple linear regression analysis revealed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate.Conclusion: A decrease in renal function causes an increase in the nighttime urine volume rate, mainly due to an increase in nighttime salt excretion.Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry)Date of registration: From June 1st, 2019 to October 31th 2020

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Impact of Nocturia on Mortality: The Nagahama Study

Cited by 22 publications

References 0 publications

Medical history of nocturnal enuresis during school age is an independent risk factor for nocturia in adults: The Nagahama study

Medical history of nocturnal enuresis during school age is an independent risk factor for nocturia in adults: The Nagahama study

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

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