Impact of nutrition on ageing and disease

Bengmark, S

doi:10.1097/01.mco.0000171129.29278.26

Cited by 47 publications

(21 citation statements)

References 44 publications

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“…Microvascular and macrovascular damage, seen in diabetes, is attributed to the accumulation of AGEs in tissues, but it is also associated with atherosclerosis, Alzheimer’s disease, end stage renal disease, rheumatoid arthritis, sarcopenia, cataracts, and other degenerative ophthalmic diseases, Parkinson’s disease, vascular dementia and several other chronic diseases [16,17,18,19]. For instance, Bar et al have demonstrated differential increases of AGEs products in Alzheimer’s dementia and vascular dementia compared to controls [20].…”

Section: Implications For Healthmentioning

confidence: 99%

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Dietary Advanced Glycation End Products and Aging

2010

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Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults. While higher AGEs occur in both healthy older adults and those with chronic diseases, research is progressing to both quantify AGEs in food and in people, and to identify mechanisms that would explain why some human tissues are damaged, and others are not. In the last twenty years, there has been increased evidence that AGEs could be implicated in the development of chronic degenerative diseases of aging, such as cardiovascular disease, Alzheimer’s disease and with complications of diabetes mellitus. Results of several studies in animal models and humans show that the restriction of dietary AGEs has positive effects on wound healing, insulin resistance and cardiovascular diseases. Recently, the effect of restriction in AGEs intake has been reported to increase the lifespan in animal models. This paper will summarize the work that has been published for both food AGEs and in vivo AGEs and their relation with aging, as well as provide suggestions for future research.

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Section: Implications For Healthmentioning

confidence: 99%

“…The accumulation of AGEs in tissues may contribute to increased OS, and as a final result, impair organ function [16]. Indeed, within the complex the association between OS and aging ovarian follicles, AGEs may have an important role as they accumulate over the lifespan [71].…”

Section: Ages In the Elderlymentioning

confidence: 99%

Dietary Advanced Glycation End Products and Aging

2010

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“…PP are present in many edible plants and thus represent an integral part of human supply [19]. Several studies have shown that high regular intake of some phenolic compounds in the diet plays a preventive action against several human diseases, such as cardiovascular pathologies, atherosclerosis, osteoporosis, allergies, diabetes, neurodegenerative diseases and cancer [20], [21]. Although the mechanisms by which these natural compounds exert their benefits are not fully understood, anti-inflammatory effects of PP have been attributed primarily to their antioxidant activity, because they were known to scavenge and prevent the formation of reactive oxygen and nitrogen species (ROS and RNS, respectively) [22], [23], which represent important hallmarks of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes

et al. 2014

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Plant polyphenols exert anti-inflammatory activity through both anti-oxidant effects and modulation of pivotal pro-inflammatory genes. Recently, Citrus bergamia has been studied as a natural source of bioactive molecules with antioxidant activity, but few studies have focused on molecular mechanisms underlying their potential beneficial effects. Several findings have suggested that polyphenols could influence cellular function by acting as activators of SIRT1, a nuclear histone deacetylase, involved in the inhibition of NF-κB signaling. On the basis of these observations we studied the anti-inflammatory effects produced by the flavonoid fraction of the bergamot juice (BJe) in a model of LPS-stimulated THP-1 cell line, focusing on SIRT1-mediated NF-κB inhibition. We demonstrated that BJe inhibited both gene expression and secretion of LPS-induced pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) by a mechanism involving the inhibition of NF-κB activation. In addition, we showed that BJe treatment reversed the LPS-enhanced acetylation of p65 in THP-1 cells. Interestingly, increasing concentrations of Sirtinol were able to suppress the inhibitory effect of BJe via p65 acetylation, underscoring that NF-κB–mediated inflammatory cytokine production may be directly linked to SIRT1 activity. These results suggest that BJe may be useful for the development of alternative pharmacological strategies aimed at reducing the inflammatory process.

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“…Over recent years, efforts have been made to identify immunological risk phenotypes in aged people, and proinflammatory phenotypes seem to predict unhealthy aging [63]. Use of nutraceuticals to prevent or arrest age-related diseases such as atherosclerosis has become very popular worldwide [64].…”

Section: Resultsmentioning

confidence: 99%

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

Jirillo

Magrone³

2011

Mediterr J Nutr Metab

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Intestinal microbiota and gut-associated lymphoreticular tissue are in a dynamic equilibrium, the rupture of which causes a condition of dysbiosis in the host.\ud Among many natural foods, milk, because of its composition, is able to influence the host–microbiota relationship.\ud Donkey’s and goat’s milk represents a good alternative to human milk. Healthy effects of both kinds of milk have been reported in either in vitro or in vivo experiments. When administered to elderly subjects, donkey’s milk increased the release of interleukins 6 and 8, while goat’s milk exerted opposite effects. With special reference to fermented cow’s milk, a symbiotic (Gorbach and Goldin) when administered to another group of elderly people, behaved as donkey’s milk upregulating interleukins 6, 8 and also 1. In conclusion, the ability of milk and fermented milk to modulate the altered immune response in senescence needs to be exploited more for maintaining healthy aging

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Impact of nutrition on ageing and disease

Cited by 47 publications

References 44 publications

Dietary Advanced Glycation End Products and Aging

Dietary Advanced Glycation End Products and Aging

Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

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