Impact of occupational noise on pure-tone threshold and distortion product otoacoustic emissions after one workday

Müller, J.; Janssen, Thomas

doi:10.1016/j.heares.2008.09.005

Cited by 19 publications

(15 citation statements)

References 65 publications

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“…[35,36] The medial olivocochlear (MOC) system has also been studied after exposure to noise. The results are contradictory with reports of no MOC influence, [34,37] and with signs of such an effect when the MOC function was measured after the exposure. [38] In the present study the NAC group, but not the control group, had a significant increase in correlated TEOAE response 3 hours after exposure (which was also 3 hours after the first NAC tablet), but showed no significant change in contralateral suppression.…”

Section: Discussioncontrasting

confidence: 98%

The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: A controlled trial

et al. 2011

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In military outdoor shooting training, with safety measures enforced, the risk of a permanent, noise-induced hearing loss is very small. But urban warfare training performed indoors, with reflections from walls, might increase the risk. A question is whether antioxidants can reduce the negative effects of noise on human hearing as it does on research animals. Hearing tests were performed on a control group of 23 military officers before and after a shooting session in a bunker-like room. The experiments were repeated on another group of 11 officers with peroral adminstration of N-acetyl-cysteine (NAC), directly after the shooting. The measurements performed were tone thresholds; transient-evoked otoacoustic emissions, with and without contralateral noise; and psycho-acoustical modulation transfer function (PMTF), thresholds for brief tones in modulated noise. Effects from shooting on hearing thresholds were small, but threshold behavior supports use of NAC treatment. On the PMTF, shooting without NAC gave strong effects. Those effects were like those from continuous noise, which means that strict safety measures should be enforced. The most striking finding was that the non-linearity of the cochlea, that was strongly reduced in the group without NAC, as manifested by the PMTF-results, was practically unchanged in the NAC-group throughout the study. NAC treatment directly after shooting in a bunkerlike room seems to give some protection of the cochlea.

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Section: Discussioncontrasting

confidence: 98%

The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: A controlled trial

et al. 2011

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“…Due to a good correlation between MOC reflex strength and PTS provoked by high-level noise, Maison and Liberman ͑2000͒ suggested MOC reflex strength to be a possible predictor for vulnerability to noise overexposure. However, this finding could not be verified in workers of a metal-working factory exposed to occupational mid-level noise for one workday ͑Müller and Janssen, 2008͒. The present study should extend the work by Müller and Janssen ͑2008͒ by studying the effects of high-level discotheque music instead of mid-level occupational noise. The study should provide information concerning the following issues: ͑i͒ do three hours of high-level discotheque music exert any measurable impact on overall hearing capability and especially on OHC functionality and if so, ͑ii͒ is there a similar effect on pure-tone thresholds and DPOAE levels;…”

Section: Introductioncontrasting

confidence: 57%

Impact of three hours of discotheque music on pure-tone thresholds and distortion product otoacoustic emissions

Müller

Dietrich

Janssen

2010

The Journal of the Acoustical Society of America

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The aim of this study was to investigate whether distortion product otoacoustic emissions (DPOAEs) are a suitable means for detecting changes in outer hair cell (OHC) functionality due to exposure to three hours of discotheque music and whether efferent reflex strength of the medial olivocochlear bundle is able to predict the ear's susceptibility to high-level noise. High-resolution DPOAEs (Δf(2)=47 Hz) were recorded between 3.5 and 4.5 kHz at close-to-threshold primary tone levels. For comparison, high-resolution pure-tone audiometry was conducted in the same frequency range. Efferent reflex strength was measured by means of DPOAEs at a specific frequency with and without contralateral acoustic stimulation. A significant deterioration of more than 10 dB was found for pure-tone thresholds and DPOAE levels indicating that three hours of high-level noise exert a considerable influence on hearing capability and OHC functionality. A significant correlation between shifts in pure-tone threshold and shifts in DPOAE level occurred when removing data with differing calibration across measurements. There was no clear correlation between efferent reflex strength and shifts in pure-tone threshold or shifts in DPOAE level suggesting that the applied measures of efferent reflex strength may not be suitable for quantifying individual vulnerability to noise.

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“…Müller and Janssen [2008] did not find any correlations between CS of DPOAE and the TTS induced by 1 day of occupational noise, or the TTS caused by 3 h of noise exposure in a discotheque [Müller et al, 2010], respectively. In some of the previous studies [Wagner et al, 2005;Müller and Janssen, 2008], the amount of TTS was rather small, thus limiting the distinction of individual noise vulnerability; further, noise exposure probably varied to some extent due to field study conditions [Veuillet et al, 1991;Wagner et al, 2005;Müller and Janssen, 2008]. In contrast, the present study included: (1) two different CS paradigms, (2) CS measurement in duplicate and (3) exactly defined experimental noise exposure under laboratory conditions.…”

Section: Discussionmentioning

confidence: 61%

Assessment of the Noise-Protective Action of the Olivocochlear Efferents in Humans

Wolpert

Heyd²,

Wagner³

2013

Audiol Neurotol

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It has been demonstrated in different mammals that the medial olivocochlear efferents (MOC) exert a noise-protective effect on the cochlea. In humans such an effect has not unambiguously been shown as of yet. The objective of this study was to assess the relationship between MOC activity and susceptibility of the cochlea to noise-induced hearing loss in humans. In 40 normally hearing human subjects, we measured the following: (1) magnitude of temporary threshold shift (TTS) after exposure to 60 min broadband noise of 94 dB SPL and (2) contralateral suppression (CS) of distortion product otoacoustic emissions (which reflects MOC activity) using two different measurement paradigms. CS was measured in duplicate on 2 measurement days. The relationship between TTS and CS was assessed. Individual TTS in the most affected frequencies (4 > 3 > 8 kHz) ranged from 9 to 28 dB HL, with an average maximum TTS of 18.4 dB HL. The amount of CS ranged between 0.3 and 3 dB. The repeatability of CS, evaluated by Cronbach's α value, ranged from 0.76 (acceptable repeatability) to 0.86 (good repeatability). One of the two different measurement paradigms showed a statistically significant inverse correlation between CS magnitude and amount of TTS, which was hypothesized. This is the first study on the relationship between TTS and CS in humans employing TTS induced under controlled laboratory conditions and two different MOC paradigms. The findings are compatible with the hypothesis that MOC activity is noise protective in humans. Future perspectives include modified CS paradigms, longitudinal cohort studies or efforts to also monitor lateral efferent effects in humans.

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Impact of occupational noise on pure-tone threshold and distortion product otoacoustic emissions after one workday

Cited by 19 publications

References 65 publications

The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: A controlled trial

The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: A controlled trial

Impact of three hours of discotheque music on pure-tone thresholds and distortion product otoacoustic emissions

Assessment of the Noise-Protective Action of the Olivocochlear Efferents in Humans

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