Impact of oocyte donation on obstetric and perinatal complications in twin pregnancies

Boria, Félix; Calle, María de la; Cuerva, Marcos Javier; Sainz, A Lopez; Bartha, José Luis

doi:10.1080/14767058.2018.1533944

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Yet, they did show a significantly higher risk for pregnancy-induced hypertension (OR 3.1; 95% CI 1.4-6.6) and preeclampsia (OR 2.5; 95% CI 1.1-5.7) in twin pregnancy compared to autologous twin pregnancies, adjusted for maternal age, geographic origin, parity, and chorionicity. Still, the results in both studies did not translate into adverse neonatal outcomes [29,30]. Jeve et al [12] recommend individualized appropriate surveillance and management for every patient achieving pregnancy by OD.…”

Section: Discussionmentioning

confidence: 97%

“…Single embryo transfer to achieve OD pregnancy is recommended by several studies [14,18,24,27] because the risk of a twin pregnancy is increased with a double embryo transfer [28]. Two recent studies documented a higher level of obstetric complications in OD twin pregnancies compared with autologous IVF and NC twin pregnancies [29,30]. Boria et al [29] showed that twin OD pregnancies are associated with a higher risk of preterm birth compared to autologous twin pregnancies (OR 3.2; 95% CI 1.15-8.86; p = 0.025), even adjustment for maternal age.…”

Section: Discussionmentioning

confidence: 99%

“…Two recent studies documented a higher level of obstetric complications in OD twin pregnancies compared with autologous IVF and NC twin pregnancies [29,30]. Boria et al [29] showed that twin OD pregnancies are associated with a higher risk of preterm birth compared to autologous twin pregnancies (OR 3.2; 95% CI 1.15-8.86; p = 0.025), even adjustment for maternal age. In a larger cohort study, Guilbaud et al [30] did not find a significant difference for preterm birth in OD twin pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians

2022

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It is well known that oocyte donation (OD) pregnancies are associated with higher complication rates compared to autologous pregnancies. However, evidence-based information for pre-pregnancy counseling designed for health care workers is scarce. Therefore, a systematic literature search was performed to find articles that address pre-pregnancy counseling before OD. A systematic search was conducted in September 2020 in various databases, including PubMed and Embase. Nine (systematic) reviews and meta-analyses were included that reported on pre-pregnancy advice in OD pregnancies. Studies are consistent in documenting a higher risk for hypertensive disorders, cesarean section, preterm birth, postpartum hemorrhage, and low birth weight. Based on these complications, pre-pregnancy advice is mentioned in all included systematic reviews to prevent complications in the next pregnancy. All studies recommend counseling women on the increased risk of complications during OD pregnancy. Other recommendations include the prophylactic use of aspirin in pregnancy and restriction to single embryo transfer. Individualized appropriate surveillance and management strategies should be considered for every patient achieving pregnancy by OD. In conclusion, we provide a summary of the most important outcomes in OD pregnancies, and thereby offer a guide for pre-pregnancy counseling.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians

2022

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“…Egg donation is increasingly being used as a fertilization procedure. It has proved to be effective in “extreme” cases of infertility or early ovarian failure, but involves a higher risk for adverse pregnancy outcomes, including pre-term delivery, preeclampsia and related disorders and giving birth to a child that is small for gestational age [7,8,9,10,11,12,13,14,15,16,17].…”

Section: Discussionmentioning

confidence: 99%

“…Notwithstanding the indications, egg donation is associated with a higher risk of virtually all adverse pregnancy outcomes, including caesarean section, preterm delivery, small for gestational age babies and the hypertensive disorders of pregnancy [4,5,6,7,8,9]. A number of elements seem to contribute to increased risk: among them, the most commonly studied ones are advanced maternal age, multiple pregnancies, and the presence of specific diseases that cause infertility [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Risk of Preeclampsia and Adverse Pregnancy Outcomes after Heterologous Egg Donation: Hypothesizing a Role for Kidney Function and Comorbidity

Fassio

Attini

Masturzo

et al. 2019

JCM

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Background and objectives: Preeclampsia (PE) is a risk factor for kidney diseases; egg-donation (ED) increasingly used for overcoming fertility reduction, is a risk factor for PE. CKD is also a risk factor for PE. However, kidney function is not routinely assessed in ED pregnancies. Objective of the study is seeking to assess the importance of kidney function and maternal comorbidity in ED pregnancies. Design, setting, participants and measurements. Design: retrospective observational study from clinical charts. Setting: Sant’Anna Hospital, Turin, Italy (over 7000 deliveries per year). Selection: cases: 296 singleton pregnancies from ED (gestation > 24 weeks), who delivered January 2008–February 2019. Controls were selected from the TOrino Cagliari Observational Study (1407 low-risk singleton pregnancies 2009–2016). Measurements: Standard descriptive analysis. Logistic multiple regression analysis tested: PE; pregnancy-induced hypertension; preterm delivery; small for gestational age; explicatory variables: age; BMI; parity; comorbidity (kidney diseases; immunologic diseases; thyroid diseases; other). Delivery over time was analyzed according to Kaplan Meier; ROC (Relative Operating Characteristic) curves were tested for PE and pre-term delivery, employing serum creatinine and e-GFR as continuous variables. The analysis was performed with SPSS v.14.0 and MedCalc v.18. Results: In keeping with ED indications, maternal age was high (44 years). Comorbidity was common: at least one potential comorbid factor was found in about 40% of the cases (kidney disease: 3.7%, immunologic 6.4%, thyroid disease 18.9%, other-including hypertension, previous neoplasia and all other relevant diseases—10.8%). No difference in age, parity and BMI is observed in ED women with and without comorbidity. Patients with baseline renal disease or “other” comorbidity had a higher risk of developing PE or preterm delivery after ED. PE was recorded in 23% vs. 9%, OR: 2.513 (CI 1.066–5.923; p = 0.039); preterm delivery: 30.2% vs. 14%, OR 2.565 (CI: 1.198–5.488; p = 0.044). Limiting the analysis to 124 cases (41.9%) with available serum creatinine measurement, higher serum creatinine (dichotomised at the median: 0.67 mg/dL) was correlated with risk of PE (multivariate OR 17.277 (CI: 5.125–58.238)) and preterm delivery (multivariate OR 2.545 (CI: 1.100–5.892). Conclusions: Within the limits of a retrospective analysis, this study suggests that the risk of PE after ED is modulated by comorbidity. While the cause effect relationship is difficult to ascertain, the relationship between serum creatinine and outcomes suggests that more attention is needed to baseline kidney function and comorbidity.

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Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

Masturzo

Martino

Prefumo

et al. 2019

Arch Gynecol Obstet

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Impact of oocyte donation on obstetric and perinatal complications in twin pregnancies

Cited by 6 publications

References 18 publications

Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians

Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians

Risk of Preeclampsia and Adverse Pregnancy Outcomes after Heterologous Egg Donation: Hypothesizing a Role for Kidney Function and Comorbidity

Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

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