The article aims to propose new approaches to cargo delivery management in global supply chains in the context of sustainable development. Recently, this issue gaining in importance and needs to be addressed, as international supply chains are becoming more complex, the range of transported goods is increasing, the requirements of the cargo clientele and the reliability of delivery in general are significantly increasing. Within the framework of the study, a critical analysis of scientific sources on cargo delivery technologies, the functioning of transport systems, the formation of global supply chains was carried out. The empirical research is based on the use of methods of systematization, deduction, expert assessments, statistical analysis — in the classification of cargo flows. Methods of statistical observation, correlation and regression analysis, mathematical modeling and optimization were used in the management of airline cargo flows and determining organizationaltechnological principles of interaction between participants in global supply chains. Scientific and practical recommendations for managing the cargo delivery technology in global supply chains are provided, which ensured the interests of all participants and allowed to unify this process in general.